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Preparation of potassium platinochloride

A technology of potassium chloroplatinite and potassium chloroplatinate is applied in chemical instruments and methods, sodium/potassium compounds, ruthenium/rhodium/palladium/osmium/iridium/platinum compounds, etc., to achieve low production cost and good operating environment , the effect of short preparation process

Active Publication Date: 2011-01-19
兰州金川科技园有限公司
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Problems solved by technology

The disadvantage of this method is that in the preparation of potassium chloroplatinate solution, hydrochloric acid is used as solvent, and its concentration is strictly limited.
And the preparation process is lengthy and the production cost is high

Method used

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  • Preparation of potassium platinochloride

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preparation example Construction

[0013] A kind of preparation method of potassium chloroplatinite, its preparation process is to adopt sponge platinum as raw material to prepare chloroplatinic acid solution and potassium chloride solution to prepare potassium chloroplatinate, then use hydrazine hydrochloride as reducing agent to reduce chloroplatinic acid Potassium preparation of pharmaceutical intermediate potassium chloroplatinite. Include the following steps:

[0014] a) Preparation of potassium chloroplatinate: Weigh a certain amount of platinum sponge, put it into a beaker after washing, add appropriate amount of aqua regia in batches, heat appropriately, and the reaction process is based on the principle of uniform bubbling. After the reaction stops, add concentrated hydrochloric acid dropwise under heating and boiling to catch the nitrate until the system no longer emits brown nitrogen oxides, and then add an appropriate amount of water to catch the acid. Filter, heat and concentrate the filtrate to t...

Embodiment 1

[0021] Weigh 100g of platinum sponge, put it into a beaker after washing, add an appropriate amount of aqua regia, and heat it appropriately. The principle of the reaction process is uniform bubbling. After the reaction stopped, the obtained solution was concentrated until crystals were precipitated, and concentrated hydrochloric acid was added dropwise to remove the nitrate until the system no longer emits brown nitrogen oxides, then concentrated until crystals were precipitated, and an appropriate amount of deionized water was added to remove the acid. Filter, and the filtrate is formulated into a 50g / L solution for subsequent use.

[0022] Weigh 80.0g of potassium chloride, make a 20% solution, filter, and use the filtrate for later use. Take the above chloroplatinic acid solution and add it dropwise to the potassium chloride solution under stirring, a yellow precipitate appears in the solution, after the dropwise addition, continue to stir for 1-2 hours to complete the rea...

Embodiment 2

[0026] The specific implementation rules are the same as example 1, and the difference is that the sponge platinum input amount is 500g, and chloroplatinic acid is mixed with a solution of 100 g / L, and potassium chloride consumption is 401g, which is made into a 20% solution, and potassium chloroplatinate is 1200g , 8000ml of distilled water was added, and the amount of reducing agent hydrazine hydrochloride was 136g. The obtained product was sampled for full elemental analysis and XRD detection, platinum content: 46.2%, potassium content: 17.6%, no compounds other than potassium chloroplatinite were detected. The product yield is 95.0%.

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Abstract

Disclosed is a method for the production of a potassium platinochloride, which relates to a process for preparing a pharmaceutical intermediate potassium platinochloride. The method of preparation is characterized in that the preparation process adopts a spongy platinum as a material to prepare a chloroplatinic acid solution which is reacted with a potassium chloride solution to prepare the potassium chloroplatinite, then a hydrazine hydrochloride is adopted as a reducing agent to reduce the potassium chloroplatinite for preparing the pharmaceutical intermediate potassium platinochloride. Theproduct adopting the method of the invention has a platinum content of 46.9+-0.2 percent and a potassium content of 19.0+-0.2 percent through a total elemental analysis. The total content of metallicimpurity is no more than 0.08 percent.

Description

technical field [0001] The invention discloses a preparation method of potassium chloroplatinite, which relates to a preparation method of a pharmaceutical intermediate potassium chloroplatinite. Background technique [0002] Potassium chloroplatinite is an important intermediate for the preparation of antitumor drugs such as carboplatin, cisplatin and oxaliplatin, and has a good market prospect. [0003] At present, there are only a few literatures reporting the preparation of potassium chloroplatinite in its laboratory. It is mentioned in the literature that potassium chloroplatinite is used as a raw material, and potassium oxalate, hydrazine hydrate and sulfur dioxide are used as reducing agents to synthesize potassium chloroplatinite. Due to the weak reducing ability of potassium oxalate, the main metal content of the synthesized product is difficult to meet the requirements; the reducing ability of hydrazine hydrate is strong, and it needs to be diluted by a certain m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G55/00C01D13/00
Inventor 李永军武浚刘会基李勇智马正明张玉祥敬春梅王红梅黄良标马天飞
Owner 兰州金川科技园有限公司
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