Extracting method of medical mangrove acanthus total flavonoids

The technology of total flavonoids of prosthesis and mangrove plants is applied in the directions of drug combination, medical raw materials derived from angiosperm subphylum, antipyretics, etc. High rate and good repeatability

Inactive Publication Date: 2008-11-19
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional methods of extracting total flavonoids include direct extraction and Soxhlet extraction, and their main disadvantages are low extraction rate or high energy consumption

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Pre-treatment of raw materials: collect fresh leaves of Bougainvillea plants in flowering stage, wash and dry in the sun, pulverize and sieve with a pulverizer, the particle size of the material is less than 0.2mm, and get Bougainvillea powder A;

[0022] 2. Ultrasonic extraction: Take 5.0g of mouse bougainvillea powder A and 40mL of solvent I and put them into the extractor. After mixing evenly, place the extractor in an ultrasonic instrument for the first extraction. Extract at 80°C for 45 minutes. After extraction, filter with suction to obtain mouse Crude extract I and residue I of bougainvillea leaf total flavonoids; put residue I into the extractor, pour 75mL solvent II, the ratio of the mass of residue I to the volume of solvent II is about 1:15, and place the extractor in an ultrasonic instrument The second extraction was carried out at 85°C for 60 minutes, and the extracted mixture was suction-filtered to obtain the crude extract II and residue II of the tota...

Embodiment 2

[0027] 1. Raw material collection and pretreatment: same as Example 1;

[0028] 2. Ultrasonic extraction: Take 5.0g of mouse bougainvillea leaf powder A and 25mL of solvent I into the extractor, mix well, place the extractor in an ultrasonic instrument for the first extraction, extract at 70°C for 45min, filter after extraction, and obtain mouse Crude extract I and residue I of bougainvillea leaf total flavonoids; put the residue I into the extractor, pour 50mL of solvent II, the volume ratio of the mass of residue I to solvent II is about 1:10, and place the extractor in an ultrasonic instrument The second extraction was carried out at 95°C for 45 minutes, and the extracted mixture was filtered to obtain the crude extract II and residue II of total flavonoids of the rat bougainvillea, and the residue II was discarded;

[0029] 3. Concentration: Mix the crude extract I and II to obtain a mixture, and place the mixture at 65°C and 6.9×10 4 Distilled under reduced pressure unde...

Embodiment 3

[0033] 1. Raw material collection and pre-treatment: collect the fresh roots of Boletus sativa plants in the flowering stage, take 5.0 g of fresh root powder A and 30 mL of solvent I and put them into the extractor, and the pre-treatment is the same as in Example 1.

[0034] 2. Except that the ratio of the mass (kg) of the residue I to the volume (L) of the solvent II is changed to 1:15, the rest are the same as in Example 2.

[0035] 3. Concentration: Concentrate by distillation under reduced pressure, the conditions are the same as in Example 2, the measured concentrated solution contains 223.0 mg of the total flavonoids of the root of the rat bougainvillea, converted into 5.0 g of the total content of the dry root is 4.46%.

[0036] Control: the total content determined by Soxhlet extraction is 3.88%; the total content determined by water extraction is 2.6%.

[0037] The solvent I and solvent II of Example 3 are the same as those of Example 2.

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PUM

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Abstract

An extraction method of total flavones in Acanthus ilicifolius which is a medicinal mangrove plant relates to the extraction method of the total flavones, in particular relates to the extraction method of the total flavones in the Acanthus ilicifolius which is the medicinal mangrove plant, and provides the extraction method of the total flavones in the Acanthus ilicifolius which is the medicinal mangrove plant, wherein, the extraction method has high extraction ratio. A whole Acanthus ilicifolius plant, or at least one species of roots, stems and leaves of the Acanthus ilicifolius plant is selected and crushed to obtain Acanthus ilicifolius powder lots A; the Acanthus ilicifolius powder lots A and solvent 1 are put in an extraction apparatus; the mixed solution is extracted to obtain suspending liquid; Acanthus ilicifolius total-flavone crude-extract liquid 1 and residues 1 are obtained through filtration and liquid-residue separation; the residues 1 and solvent 2 are put in the extraction apparatus for extraction; mixture after extraction is filtered, so as to obtain Acanthus ilicifolius total-flavone crude-extract liquid 2; the Acanthus ilicifolius crude-extract liquid 1 and the Acanthus ilicifolius crude-extract liquid 2 are mixed to obtain mixed solution, and then the total flavones is obtained after reduced pressure distillation.

Description

technical field [0001] The invention relates to a method for extracting total flavonoids, in particular to a method for extracting total flavonoids of the medicinal mangrove plant Bougainvillea. Background technique [0002] mouse bougainvillea ( Acanthus illicifolius L) is Acanthaceae (Acanthaceae), a medicinal mangrove plant of the genus Acanthus, which grows in the intertidal zone of the coast, and is mainly distributed in tropical and subtropical countries or regions in Southeast Asia such as India, the Philippines, and Malaysia, Guangdong, Guangxi, and Fujian in my country and Hainan are also distributed. The plant is a shrub or a subshrub, and it is an important marine higher medicinal plant included in the "National Chinese Herbal Medicine Compilation" (1978) ([1] Peng Xing, Long Shengjing. Study on the chemical constituents of rat bougainvillea [J]. Chinese herbal medicine 2006 , 37(7):971-973). It is widely used in the folk to treat acute and chronic hepatitis, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61P1/16A61P35/00A61P39/06A61P11/06A61P29/00A61P17/02
Inventor 胡宏友诸姮卢昌义
Owner XIAMEN UNIV
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