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Echinacea purpurea oral liquid and preparation method and application thereof

A kind of Echinacea purpurea oral liquid, the technology of Echinacea purpurea, applied in the direction of medical formula, medical preparations containing active ingredients, allergic diseases, etc., can solve the problems of low extraction rate of active ingredients, high degradation of active ingredients, large amount of solvent usage, etc. Achieve the effects of improving extraction efficiency and selectivity, reducing degradation, and shortening extraction time

Active Publication Date: 2011-10-26
QINGDAO VLAND BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides an echinacea purpurea oral liquid and its preparation method and application, which can solve the problems of low extraction rate of active ingredients, long extraction time, large amount of solvent used, high extraction temperature and high degradation of active ingredients existing in the prior art

Method used

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  • Echinacea purpurea oral liquid and preparation method and application thereof
  • Echinacea purpurea oral liquid and preparation method and application thereof
  • Echinacea purpurea oral liquid and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] First crush the Echinacea purpurea medicinal material with a moisture content of ≤12.0%, pass it through a 80-mesh sieve, and weigh 1000g; add 8000ml of 70% ethanol solution and mix it with the Echinacea purpurea powder, soak for 30 minutes, extract twice with microwave, and the microwave radiation frequency is 2400-2500 MHz , the extraction temperature is 60°C, each extraction time is 10 minutes, filter and collect the filtrate and residue; the residue is mixed with 20% ethanol solution at a solid-liquid ratio of 1:5, microwave extraction is performed once, and the microwave frequency is 2400- 2500 MHz, the extraction time is 10 minutes, the extraction temperature is 60°C, filter, collect the filtrate, and combine the above filtrates; recover the ethanol from the filtrate under reduced pressure at 40°C, concentrate to a relative density of about 1.04, add an appropriate amount of p-hydroxybenzene Fully dissolve ethyl formate, adjust the pH value of the liquid to 4.0 wit...

Embodiment 2

[0065] First, crush the Echinacea purpurea medicinal material with a moisture content of ≤12.0%, pass through a 80-mesh sieve, weigh 1000g; add 10000ml of 70% ethanol solution and mix it with the Echinacea purpurea powder, soak for 30 minutes, and extract twice with microwaves. The microwave radiation frequency is 2400-2500 MHz , the extraction temperature was 60°C, each extraction time was 15 minutes, filtered and collected the filtrate and residue; the residue was mixed with 20% ethanol solution at a solid-liquid ratio of 1:5, microwave extracted once, and the microwave frequency was 2400- 2500 MHz, the extraction time is 10 minutes, the extraction temperature is 60°C, filter, collect the filtrate, and combine the above filtrates; recover the ethanol from the filtrate under reduced pressure at 40°C, concentrate to a relative density of about 1.03, add an appropriate amount of p-hydroxybenzene Fully dissolve ethyl formate, adjust the pH value of the liquid to 4.5 with a certai...

Embodiment 3

[0068] First, crush the Echinacea purpurea medicinal material with a moisture content of ≤12.0%, pass through a 80-mesh sieve, weigh 2000g; add 20000ml of 70% ethanol solution and mix it with the Echinacea purpurea powder, soak for 30 minutes, extract twice with microwave, and the microwave radiation frequency is 2400-2500 MHz , the extraction temperature is 60°C, each extraction time is 10 minutes, filter and collect the filtrate and residue; the residue is mixed with 30% ethanol solution at a solid-liquid ratio of 1:5, microwave extraction is performed once, and the microwave frequency is 2400- 2500 MHz, the extraction time is 10 minutes, the extraction temperature is 60°C, filter, collect the filtrate, and combine the above filtrates; recover the ethanol from the filtrate under reduced pressure at 40°C, concentrate to a relative density of about 1.10, add an appropriate amount of p-hydroxybenzene Fully dissolve ethyl formate, adjust the pH value of the liquid to 4.0 with a c...

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Abstract

The invention provides echinacea purpurea oral liquid and a preparation method and application thereof, which can solve the problems of low yield for extraction of an effective ingredient, long extraction time, large using amount of a solvent, high extraction temperature and high degradation of the effective ingredient. The chicoric acid content of the oral liquid is 3 to 30mg / ml; and the echinacea purpurea oral liquid is prepared from echinacea purpurea serving as a raw material by crushing, microwave extraction, filtration, condensation, encapsulation and sterilization. The invention also discloses application of the echinacea purpurea oral liquid in improving the immunity function of animals. The method ensures high yield of the effective ingredient, shortens the extraction time, reduces the extraction temperature, the degradation of the effective ingredient and the using amount of the extraction solvent, improves the production efficiency, saves the production cost and has good application and popularization prospect by taking solution of ethanol with different concentrations as the extraction solvent and using the microwave radiation-assisted extraction.

Description

technical field [0001] The invention belongs to the field of herbal pharmaceutical products, and relates to an animal immune enhancer, in particular to an echinacea purpurea oral liquid and its preparation method and application. Background technique [0002] Echinacea ( Echinacea purpurea ) is a perennial herbaceous plant of the genus Echinacea in the Compositae family. It is native to the central and western regions of North America and has been introduced in some provinces and cities in my country. It is an immune booster and immune regulator, and it can also be antiviral, anti-inflammatory, anti-tumor, and treat colds and acute and chronic upper respiratory tract infections. The research results show that its flowers, flowering branches, leaves and roots contain a large amount of caffeic acid derivatives, alkylamides, polysaccharides, alkaloids and other substances. Coffee tartaric acid and artichoke glycosides, among which cichoric acid is the main physiologically act...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K9/08A61P37/04A61P31/04A61P31/12A61K31/216
Inventor 郝智慧王春元贾德强王艳玲庞云露
Owner QINGDAO VLAND BIOTECH INC
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