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Preparation technique for specified transfer factor oral preparation for typhoid fever, paratyphoid fever

A technology of transfer factor and oral preparations, applied in the direction of resistance to vector-borne diseases, medical preparations containing active ingredients, peptide/protein components, etc., can solve the problems of no emergency prevention and treatment of typhoid fever, lack of vaccines, etc., and achieve enhanced non-specific Heterosexual immune function, obvious effect, cost-saving effect

Inactive Publication Date: 2008-12-03
ZUNYI MEDICAL UNIVERSITY
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Problems solved by technology

[0007] Typhoid and paratyphoid are currently mainly treated with chemical drugs. Chemical drug treatment has led to the emergence of more and more drug-resistant strains, and there is a lack of effective vaccines; there are no biological products for emergency prevention and treatment of typhoid and paratyphoid.

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  • Preparation technique for specified transfer factor oral preparation for typhoid fever, paratyphoid fever

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Embodiment Construction

[0029] Embodiment of the present invention: prepare typhoid and paratyphoid specific transfer factor oral preparations according to the following steps:

[0030] (1) Prepare typhoid and paratyphi Salmonella immunogens: get Salmonella typhi H 901 Strain, O 901 Strain and Salmonella paratyphi three strains of brain heart infusion solid medium 20 hours culture, H 901 After the 20-hour culture of the strain was dissolved with 0.4% formaldehyde saline, the bacteria solution was sterilized in a refrigerator at 4°C for 3-5 days, O 901 strain and Salmonella paratyphi strain were dissolved in 0.5% carbolic acid saline for 20 hours respectively, and the bacteria solution was sterilized overnight in a 37°C incubator; the bacteria solution was washed twice by centrifugation at 500r / m, according to the calculation formula: number of bacteria = OD 500 / 1.25×2×10 9 , H after killing 901 strain, O 901 Bacterial strains and Salmonella paratyphi strains were prepared into 500 million bacte...

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Abstract

The invention discloses a process for preparing a typhoid and paratyphoid specific transfer factor oral preparation. The process mainly comprises the following steps of the preparation of immunogen, in vivo immunization of animals, and in vitro immune animal lymphocyte, the preparation of the specific transfer factors of typhoid and paratyphoid, etc. The oral preparation has the functions of transferring cell information, mediating cell immunoreaction, inhibiting specificity and killing salmonella of typhoid and paratyphoid, and also has the function of strengthening nonspecific immunity; the oral preparation has the advantages of no allergic reaction after being taken, safe use and obvious effect, and no drug resistance is generated in a patient who takes the oral preparation; and the product which adopts the oral dosing is not limited by drug taking condition, so that the product is convenient without affecting the biological activity of effective ingredients, is a safe and effective preparation and has good social value and market application prospect.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a preparation process for oral preparations of typhoid and paratyphoid specific transfer factor. Background technique [0002] Typhoid fever (typhiod fever) is caused by Salmonella typhi, and humans are its only natural host and reservoir. It mainly occurs in school-age children, young adults and tourists, and mostly contaminates food and It is transmitted by water, and the peak season of the disease is from July to September. So far, typhoid fever is still a global public health problem. There are reports of typhoid fever all over the world, and it is more common in tropical and subtropical regions. With the improvement of social development and public health conditions, the incidence of typhoid fever has declined, but there is still a trend of endemic or local outbreaks in developing countries. Typhoid fever is still a high-incidence area in my country's Guizhou, Guangxi, Yunnan,...

Claims

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Application Information

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IPC IPC(8): A61K38/19A61K35/26A61P31/04
CPCY02A50/30
Inventor 孙万邦罗军敏王翔
Owner ZUNYI MEDICAL UNIVERSITY
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