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Xylaria nigripes fermentation liquor powder and preparation and use

A technology of C. nigritiformis and fermentation liquid, which can be applied to medical preparations containing active ingredients, plant/algae/fungus/moss components, plant raw materials, etc., and can solve the problems of insufficient production process research

Inactive Publication Date: 2010-12-08
毛延卿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, domestic research on C. nigritiformis mainly focuses on pharmacological effects, and there are not many researches on the production process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the preparation of fermented broth powder of C. nigriscens

[0018] Get the C. nigricans bacterial classification and inoculate in the seed tank by 5% inoculation amount, the formula of seed tank culture solution is 30 grams of glucose, 20 grams of corn flour, 15 grams of soybean flour, 0.8 grams of magnesium sulfate, 1000 milliliters of water, pH5 .6, the culture temperature is 25 degrees, and the rotation speed of 125 rpm is stirred. The culture time is about 4 days. After the culture medium is filled with mycelium, it is transferred to a fermenter for cultivation. The formula of the culture medium in the fermenter is 25 grams of glucose, 25 grams of corn flour, 20 grams of soybean flour, 0.8 grams of magnesium sulfate, citric acid 0.6 grams, 1000 milliliters of water, pH 5.8, cultivation temperature 22 degrees, cultivation time about 4-6 days, the fermentation can be terminated when the culture medium is full of mycelia. Separate the fermented product ...

Embodiment 2

[0019] Embodiment 2: the preparation of fermented broth powder of C. nigriscens

[0020] Get the C. nigricans bacterial classification and inoculate in the seed tank by 10% inoculation amount, the formula of seed tank culture solution is 15 grams of glucose, 10 grams of corn flour, 35 grams of soybean flour, 0.6 gram of magnesium sulfate, 0.5 gram of zinc sulfate, 1000 milliliters of water, pH 5.6, culture temperature 25 degrees, stirring at 100 rpm. The culture time is about 4 to 6 days. After the culture medium is filled with mycelium, it is transferred to a fermenter for cultivation. The formula of the culture medium in the fermenter is 25 grams of glucose, 45 grams of corn flour, 10 grams of soybean flour, and 0.8 grams of magnesium sulfate. 0.4 grams of zinc sulfate, 0.6 grams of citric acid, 1000 milliliters of water, pH 5.8, culture temperature 23 degrees, culture time about 4 to 6 days, the fermentation can be terminated when the culture medium is full of mycelia. The...

Embodiment 3

[0021] Embodiment 3: the application of the fermented broth powder of C. nigriscens in the preparation of diabetes medicine

[0022] Take 36 mice and divide them into 3 groups, 12 in each group, which are respectively model group, blank group, and C. nigritifera fermentation liquid powder group. After 72 hours, all mice were fasted for 21 hours, and 0.3ml of blood was collected from the orbit, and the blood glucose measured by glucose oxidase method was the blood glucose of the mice before administration. level, and a standard diabetic mouse model was prepared. Then, the fermented liquid powder group of C. nigritiformis was infused with the fermented liquid powder of C. nigriscens at a dose of 2 g / kg, twice a day for 3 consecutive days. The blank group and the model group were given normal saline in the same way as the control group. After 3 days, all mice were fasted for 12 hours, and 0.5 ml of blood was taken by decapitation to measure blood sugar. The results showed that ...

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Abstract

The invention discloses a Xylaria nigripes fermented liquid powder, the preparation and application thereof. The Xylaria nigripes fermented liquid powder is obtained by carrying out the liquid fermentation of Xylaria nigripes, obtaining mycelium and fermented liquid through solid-liquid separation, filtering monosaccharide, amino acid and other small-molecular organic compounds and inorganic salts of the fermented liquid by an ultrafiltration membrane, then drying and grinding. The powder is characterized in that the powder excludes mycelium, eliminates a plurality of inorganic salts, monosaccharide and amino acid of the fermented liquid and preserves the main active component of the fermented liquid such as Xylaria nigripes polysaccharide. The Xylaria nigripes fermented liquid powder canbe used for preparing medicine, health care product and food for regulating immunity, improving sleep, resisting anxiety and depression, curing migraine, relieving cough, resisting inflammation and curing phthisis, HBV hepatitis, prostatitis, tumor, female dysmenorrheal and diabetes.

Description

(1) Technical field [0001] The invention relates to a fermented liquid powder of C. nigriscens and its preparation and application. (2) Background technology [0002] Xylaria nigripes (Kl.) Sacc, known as Wuling ginseng and chicken fir egg in China. It belongs to the subphylum Ascomycota, the order Xylariales, the family Xylariaceae, and the genus Xylaria. The fungus C. nigriscens grows in the abandoned nest of the black-winged soil termite. It is a mesophilic fungus with a sweet taste and enters the three meridians of the heart, kidney and bladder. It is a blindly nourishing traditional Chinese medicine that is often combined into prescriptions when old Chinese doctors treat intractable diseases. [0003] As a rare species, C. nigritiformis is widely distributed in my country, but its output is very small. The price of natural fruiting bodies is comparable to gold. Fortunately, there are already artificially cultivated C. nigricans products on the market. These products...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/062A61P1/16A61P11/14A61P13/08A61P15/00A61P25/06A61P25/20A61P25/22A61P25/24A61P29/00A61P31/20A61P35/00
Inventor 杨国良杨勇杰张萍
Owner 毛延卿
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