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Bio-artificial materials with tuneable properties

A biomaterial, plastic technology, applied in the field of biomaterials and implants, can solve problems that limit the treatment methods of diseases and the development of patient failure repair processes

Active Publication Date: 2009-01-28
UCL BUSINESS PLC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This lack of understanding also limits the development of new treatments for diseases or failed repair processes in patients

Method used

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  • Bio-artificial materials with tuneable properties
  • Bio-artificial materials with tuneable properties
  • Bio-artificial materials with tuneable properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0089] Acellular Collagen Gel Formation

[0090] Acellular collagen gels were prepared by pH titration of type I collagen. To prepare collagen gels, 0.3 ml of 10X Eagles MEM solution (Gibco, Paisley, UK) and 0.3 ml of Dulbeccos' modified eagles medium (Gibco) were added to 2.4 ml of rat tail type I collagen (in acetic acid, Protein concentration = 2.14 mg / ml, First Link, Birmingham, UK). The solution was neutralized with 5M NaOH until a color change (from yellow to cirrus pink) was observed (Prajapati et al. 2000 Wound Rep. Regen. 8 227-238; Prajapati et al. 2000 Wound Rep. Regen. 8 239 -247). Collagen gels were inserted into wells (22mm x 33mm x 10mm) for 30 minutes at room temperature.

[0091] plastic compression

[0092] After insertion, the collagen gel was compressed by 93% with a modification of the standard plastic compression method from Brown et al. (2005) Adv. Funct. Mater. 15, 1762-70. The collagen gel was placed between two nylon sieves (35mm×70mm), the lower...

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Abstract

This invention relates to methods for preparing biomaterials by applying multiple cycles of tensile loading to compacted collagen gels in order to fuse the collagen fibrils together within the compacted gels. This produces a biomaterial with improved material properties. Biomaterials produced by such methods may be useful, for example, as tissue equivalent implants, in the repair and / or replacement of damaged tissue in an individual.

Description

technical field [0001] The present invention relates to methods of manufacturing artificial biomaterials and tissue-equivalent implants for repairing and / or replacing damaged tissue in an individual, as well as biomaterials and implants produced by such methods. Background technique [0002] The mechanical properties (that is, functional properties) of most connective tissues depend on fibrin collagen and its three-dimensional structure. Because most chronic, age-related sports surgery and trauma injuries in modern Westerners are associated with these connective tissues, impairment of collagen function is said to represent an important clinical factor affecting quality of life and flexibility. Consequently, most of the major new developments in tissue engineering and regenerative medicine have focused on the reconstruction of collagen structures or the induction of regeneration (R.A. Brown, in Future Strategies for Tissue and Organ Replacement (Eds: J.M. Polak, L.L. Hench, P...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/38A61L27/52C12N5/07C12N5/079
CPCA61L27/52A61L27/24A61L27/38A61L27/3804
Inventor 昂伯·奇马卓子斌罗伯特·布朗
Owner UCL BUSINESS PLC
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