Pharmaceutical uses of polyene phosphatidyl choline for treating cognitive impairment

A technology for polyene phosphatidylcholine and cognitive dysfunction, applied in the field of medicine and biology, can solve the problems of large side effects, many adverse reactions, and few applications, and achieves protection and promotion of health, extremely toxic and side effects, and less toxic and side effects. Effect

A technology for polyene phosphatidylcholine and cognitive dysfunction, applied in the field of medicine and biology, can solve the problems of large side effects, many adverse reactions, and few applications, and achieves protection and promotion of health, extremely toxic and side effects, and less toxic and side effects. Effect

CN101366720BInactive Publication Date: 2012-05-23FOURTH MILITARY MEDICAL UNIVERSITY
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  • Pharmaceutical uses of polyene phosphatidyl choline for treating cognitive impairment
  • Pharmaceutical uses of polyene phosphatidyl choline for treating cognitive impairment
  • Pharmaceutical uses of polyene phosphatidyl choline for treating cognitive impairment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Clinical observation of polyene phosphatidylcholine improving cognitive dysfunction

[0033] The research group of the present invention has devoted itself to the basic and clinical research on the diagnosis and treatment of mild cognitive impairment (MCI) and dementia for several years. In the early intervention study of MCI, it was found through experimental observation and statistical induction that polyene phosphatidylcholine, which is widely used in liver protection therapy, can improve cognitive function. The specific research results are as follows.

[0034] MCI patients admitted to Xijing Hospital of Fourth Military Medical University from March 2007 to July 2008 were collected. The cognitive function evaluation of the subjects before the intervention: 24 points ≤ Mini-Mental State Scale (MMSE) ≤ 26 points, adult The memory quotient (MQ) of the Webster memory test is 55-79 points. Most of the enrolled subjects have risk factors for cerebrovascular diseases ...

Embodiment 2

[0039] Animal experiment of polyene phosphatidylcholine in improving post-stress cognitive impairment

[0040] On the basis of clinical observations, animal experiments were carried out to verify whether polyene phosphatidylcholine also has the synergistic effect of improving post-stress cognitive impairment. In the pre-experiment, rats were trained in an eight-arm radial maze (continuously for 8 weeks) until the formation of learning and memory, and then the Communication Box psychological stress model was used to generate psychological stress through visual and auditory channels by watching other rats suffer from electric shocks. Rats were continuously subjected to psychological stress for 14 days and 30 min / d. At the beginning of the experiment, normal saline and polyene phosphatidylcholine (142.5 mg / kg / d) were given by oral gavage. Observation of working memory errors and reference memory errors on days 1, 3, 7, and 14. Access to a food arm was a working memory error, and...

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Abstract

The invention provides medicinal application of polyene phosphatidylcholine in treating cognitive functional disorder, which adopts a clinically commonly used medicine for protecting the liver - the polyene phosphatidylcholine to be a novel medicine for treating the cognitive functional disorder. As proved by clinical application and animal experiments, the polyene phosphatidylcholine has influence on improving the cognitive functional disorder and the memory function and has good effect of treating the cognitive functional disorder. Due to introduction of 'polyene' radicals which are more fat-soluble, the polyene phosphatidylcholine is more favorable to pass through blood-brain barriers and can be completely taken by neurons; and choline products produced by decomposition of the polyene phosphatidylcholine by the neurons can be further synthesized into acetylcholine in the neurons, thereby compensating for choline exhausted by synaptic clefts. The polyene phosphatidylcholine can generate the choline, DHA and an arachidonic acid during the process of metabolism, is a medicine for treating the cognitive functional disorder which has moderate price and small toxic and side effect, and is safe and reliable, and can also become a medicine for improving intelligence.

Description

technical field [0001] The invention belongs to the field of medical biotechnology, and relates to a new drug effect of a marketed drug, that is, the marketed drug can be used as an effective drug for cognitive dysfunction, specifically a polyene phosphatidylcholine for treating cognitive dysfunction drug use. Background technique [0002] (1) Cognitive function and cognitive impairment [0003] Cognitive function refers to various conscious and complex high-level central activities of human beings in the awakened state, including simple determination, perception, and understanding of oneself and the environment, to memory, calculation, judgment, and execution of commands, and completion of complex tasks. Cognitive dysfunction refers to different degrees of damage to cognitive function, severe cases such as various types of dementia, mild cases such as mild cognitive dysfunction. Because the latter has the value of early intervention, it has become a hot spot of internatio...

Claims

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Application Information

Patent Timeline
23 May 2012
Publication
CN101366720B
IPC
A61K31/661; A61P25/28
Inventors
邓艳春; 冯国栋