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Planar registration of multi-well plate from well side

A flat, reaction plate technology, applied in the field of laboratory equipment, can solve problems such as inconsistent thickness of the transparent bottom, hindering scanning accuracy, etc.

Inactive Publication Date: 2009-02-18
BIO-RAD CORP OF AMERICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Inconsistencies in the thickness of the transparent bottom will further hamper scanning accuracy

Method used

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  • Planar registration of multi-well plate from well side
  • Planar registration of multi-well plate from well side
  • Planar registration of multi-well plate from well side

Examples

Experimental program
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Embodiment Construction

[0016] While the features defining the invention can be implemented in various configurations, the invention is best understood as a whole by a detailed examination of the specific embodiments. One such embodiment is shown in the accompanying drawings.

[0017] figure 1 A unit 11 configured to support an inverted microtiter plate in the manner of the invention is shown in perspective view, holding the microtiter plate in planar alignment. figure 2 The inverted microtiter plate 12 itself is shown in top view. The supporting unit 11 comprises three rectangular plates, two of which are non-movable upper plate 13 and lower plate 14, and the third is an intermediate plate 16 arranged between the upper plate and the lower plate. The upper plate 13 and the lower plate 14 are approximately equal to each other in length and width and are rigidly secured to each other in parallel relationship (hence termed "fixed" herein) by four pads 15, at the four corners of each plate. There is ...

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Abstract

A multi-well plate such as a microtiter plate is secured from its well side in a manner that corrects or compensates for any deviations of the plate base from a planar configuration. This is achieved by an apparatus that includes an array of posts with exposed tips that define a plane, a plurality of movable collets that, when appropriately actuated, seize the walls of selected wells, and a biasing means to urge the collets in a direction that forces the wells of the microtiter plate against the exposed tips of the posts.

Description

technical field [0001] The present invention is generally in the field of laboratory equipment for use in the simultaneous array arrangement of a large number of substances or reaction media in a single well of microtiter plates and multiwell plates configured Integrate for performing a large number of small volume assays simultaneously. In particular, the present invention addresses problems that arise when arrays on these plates are read or monitored by optical scanning. Background technique [0002] A standard microtiter plate with 96 wells in a 12 x 8 array with 9 mm spacing between wells is an example of a variety of multiwell plates used in performing automated chemical or biochemical assays for purposes such as Screening or determining the binding affinity, reactivity or other properties of a large number of species. Other multiwell plates contain as few as 24 wells or as many as 1536 wells, with various sizes in between. The substances analyzed in these plates are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L9/00
CPCB01L9/50B01L2300/0829G01N2035/0493G01N35/0099G01N35/028B01L9/523G01N2035/042B01L9/56
Inventor 朱耀民
Owner BIO-RAD CORP OF AMERICA
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