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Methods for damaging cells using effector functions of anti-CDH3 antibodies

An effector and cell technology, applied in the direction of anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, chemical instruments and methods, anti-animal/human immunoglobulin, etc., can solve proliferation and difficult recovery And other issues

Inactive Publication Date: 2009-05-13
ONCOTHERAPY SCI INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although recent medical advances have made great strides in diagnosis, there are still many HCC patients who are diagnosed at an advanced stage and who still struggle to fully recover from the disease
In addition, since patients with cirrhosis or chronic hepatitis are at high risk for HCC, these patients may proliferate multiple liver tumors or new tumors even after complete resection of the original tumor

Method used

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  • Methods for damaging cells using effector functions of anti-CDH3 antibodies
  • Methods for damaging cells using effector functions of anti-CDH3 antibodies
  • Methods for damaging cells using effector functions of anti-CDH3 antibodies

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0151] Hereinafter, the present invention will be further described based on examples.

[0152] cell line:

[0153] Human pancreatic, lung, colon, prostate, breast, gastric or liver cancer cell lines were propagated as monolayers in appropriate media containing 10% or 20% fetal bovine serum. The cell lines used in the experiments are shown in Table 1.

[0154]

[0155]

[0156]

[0157]

[0158]

[0159] E-MEM; Eagle's basal medium

[0160] F-12; F-12 Nutrient Mixture (HAM)

[0161] L-15; Leibovitz's L-15 medium

[0162] McCoy; Modified McCoy's 5A Medium

[0163] RPMI; RPMI 1640 Medium

[0164] ATCC; American Type Culture Collection

[0165] HSRRB; Health Sciences Research Resource Bank

[0166] JFCR; Japan Foundation for Cancer Research

[0167] TKG; Institute of Development, Aging, and Cancer, Tohoku University

[0168] Furthermore, the following cell lines were used in ADCC assays using anti-CDH3 antibodies:

[0169] Pancreatic cancer cell line KLM-...

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Abstract

The present invention relates to the use of cytotoxicity based on the effector function of anti-CDH3 antibodies. Specifically, the present invention provides methods and pharmaceutical compositions that comprise an anti-CDH3 antibody as an active ingredient for damaging CDH3-expressing cells using antibody effector function. Since CDH3 is strongly expressed in pancreatic, lung, colon, prostate, breast, gastric or liver cancer cells, the present invention is useful in pancreatic, lung, colon, prostate, breast, gastric or liver cancer therapies.

Description

[0001] This application claims the benefit of US Provisional Application Serial No. 60 / 778,079, filed February 28, 2006, the entire contents of which applications are hereby incorporated by reference. technical field [0002] The present invention relates to methods of using the effector functions of anti-CDH3 antibodies to damage cells or compositions for this purpose. Background technique [0003] The mortality rate of patients with pancreatic cancer is higher than any other type of malignant tumor, and the 5-year survival rate is only 4% (Greenlee et al., (2001) CA. Cancer J. Clin.; 51:15-36.). This malignancy is difficult to diagnose early and current therapies are poorly effective, which is reflected in poor prognosis (DiMagno et al., (1999) Gastroenterology.; 117:1464-84; Greenlee et al., (2001) CA. Cancer J. Clin .;51:15-36.). Especially in the earlier, potentially efficaciously treatable stages of the disease there are no clinically available tumor markers. Surgica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/18A61P35/00
CPCC07K2317/732C07K16/30A61P35/00
Inventor 中鹤修一吉川惠美广岛真一
Owner ONCOTHERAPY SCI INC