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Anti-cancer activity augmentation compounds and formulationsand methods of use thereof

A technology of anti-cancer activity and disulfide compounds, applied in the direction of active ingredients of heterocyclic compounds, organic active ingredients, inorganic active ingredients, etc., can solve the problem of enhancing cytotoxicity

Active Publication Date: 2009-05-27
BIONUMERIK PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, as described herein, apart from the novel concepts and practices of the present invention, there are currently no drugs approved for enhancing tumor cell killing or increasing cytotoxicity to cancer cells in a selective manner while avoiding the Adverse effects induced by chemotherapeutic agents on normal (ie, non-cancerous) cells and tissues

Method used

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  • Anti-cancer activity augmentation compounds and formulationsand methods of use thereof
  • Anti-cancer activity augmentation compounds and formulationsand methods of use thereof
  • Anti-cancer activity augmentation compounds and formulationsand methods of use thereof

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Embodiment Construction

[0054] The description and embodiments described herein are not intended to be exhaustive, nor are they intended to limit the invention to the particular forms disclosed. They are provided to illustrate the principles of the invention, and its application and practical utilization by those skilled in the art. definition

[0055] "Skeleton" or "general structural formula" refers to the fixed structural portion of a given molecular formula.

[0056] "Nucleophile" means an ion or molecule that donates a pair of electrons to its nucleus to form a covalent bond; nuclei that accept electrons are called electrophiles. This occurs, for example, when forming acids and bases according to the Lewis concept, and when forming covalent carbon bonds in organic compounds.

[0057] A "fragment," "moiety," or "substituent" refers to a variable portion of a molecule named in a formula by a variable symbol, such as Rx, X, or other symbols. Substituents can consist of one or more of the followi...

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PUM

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Abstract

The field of the present invention comprises pharmaceuticals and pharmaceutical treatments, including, for example, (i) compounds and formulations which cause the augmentation of anti-cancer activity (i.e., by enhancement of the lethal cytotoxic action in stimulatory [inducing oxidative stress] and / or depletive [decreasing anti-oxidative capacity] manner) of chemotherapeutic agents, in a selective manner; (ii) methods of administering said anti-cancer augmentation compounds and formulations; (iii) delivery devices containing said anti-cancer augmentation compounds and formulations; and (iv) methods of using said anti-cancer augmentation compounds, formulations, and devices to treat subjects in need thereof.

Description

[0001] related application [0002] This application claims priority to US Provisional Patent Application 60 / 782,826, filed March 16, 2006, entitled: "Anticancer Activity Potentifying Compounds and Formulations and Uses Thereof." technical field [0003] The present invention relates to drugs and drug therapies, including compounds and preparations that cause enhanced anticancer activity, for example by enhancing the lethal cytotoxicity of chemotherapeutic agents, and administering such compounds and agents that cause enhanced anticancer activity of chemotherapeutic agents to a subject in need thereof Method of preparation. The invention also relates to devices for administering said compounds and formulations to treat a subject in need thereof. Background of the invention [0004] With the increase in the number of drugs and therapies for cancer and the number of subjects receiving one or more of these chemotherapeutic agents concurrently, clinicians and researchers are en...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/33A61K33/243
CPCA61K9/0019A61K31/095A61K33/24A61K31/555A61K45/06A61K31/255A61P35/00A61K33/243A61K2300/00
Inventor F·H·豪歇尔
Owner BIONUMERIK PHARMA INC