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Rhizoma atractylodis arborinol inclusion compound, medicinal combination thereof and preparation method

A technology of total terpene alcohols and inclusion compounds, which is applied in the field of inclusion compounds and preparations containing total terpene alcohol extracts of Atractylodes atractylodes, which can solve the problems of low dissolution and bioavailability of conventional preparations and difficulties in forming preparations of total terpene alcohol extracts of Atractylodes atractylodes and other problems, to achieve the effect of good appearance, good storage stability and good dissolution rate

Inactive Publication Date: 2012-01-04
深圳海创医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The purpose of the present invention is to provide a total terpene alcohol inclusion compound of Atractylodes atractylodis, which solves the disadvantages of the difficulty in forming the preparation of the total terpene alcohol extract of Atractylodes atractylodis and the low dissolution rate and bioavailability of conventional preparations.

Method used

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  • Rhizoma atractylodis arborinol inclusion compound, medicinal combination thereof and preparation method
  • Rhizoma atractylodis arborinol inclusion compound, medicinal combination thereof and preparation method
  • Rhizoma atractylodis arborinol inclusion compound, medicinal combination thereof and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1. Preparation of Atractylodes total terpene alcohol β-cyclodextrin inclusion compound by different methods

[0043] This example investigates the preparation of Atractylodes total terpene alcohol β-cyclodextrin inclusion compound by different preparation methods. Mix the total terpene alcohol extract of Atractylodes Rhizome with β-cyclodextrin at a mass ratio of 1:10, and prepare the total terpenes of Atractylodes Rhizome according to different preparation methods such as saturated solution method, ultrasonic method, grinding method, microwave radiation saturated aqueous solution combined with spray drying method, etc. Alcohol β-cyclodextrin inclusion complex.

[0044] Grinding method: put the total terpene alcohol extract of Atractylodes atractylodes and cyclodextrin and cyclodextrin derivatives in a grinder, add an appropriate amount of ethanol to mix, grind at a speed of 200-600rpm / min for 30-180min, and fully grind to a paste. Volatile to remove ethanol, g...

Embodiment 2

[0057] Example 2. Preparation of Atractylodes atractylodis total terpene alcohol inclusion compound with hydroxypropyl-β-cyclodextrin as inclusion material

[0058] This example investigates the preparation of total terpene alcohol inclusion compound of Atractylodes atractylodis with hydroxypropyl-β-cyclodextrin as the inclusion material. The preparation method is the same as that in Example 2 in combination with microwave radiation saturated aqueous solution and spray drying method. A blank experiment was carried out, and the dissolution rate of atractyl alcohol in artificial gastric juice, distilled water, and phosphate was detected according to the method described in the instructions, and the results are shown in Table 2.

[0059] Table 2 Hydroxypropyl-β-cyclodextrin is the dissolution rate of atractylodes alcohol in the total terpene alcohols of atractylodis

[0060]

[0061] This example shows that the preparation of total terpene alcohol hydroxypropyl-β-cyclodextrin ...

Embodiment 3

[0062] Example 3 Preparation of Atractylodes atractylodis total terpene alcohol inclusion compound with different cyclodextrins as inclusion materials

[0063] This example investigates the preparation of atractylodes total terpene alcohol cyclodextrin inclusion complexes of different cyclodextrin inclusion materials. The preparation method is the same as that in Example 1 in combination with microwave radiation saturated aqueous solution and spray drying method. The ratio of total terpene alcohol extract of Atractylodes atractylodis to saturated material is 1:10 (mass ratio). The dissolution rate of atractyl alcohol in artificial gastric juice, distilled water and phosphate was detected according to the method described in the specification of the present invention, and the results are shown in Table 3.

[0064] Table 3. The dissolution rate of atractylodes alcohol in the total terpene alcohol inclusion compound of Atractylodes atractylodis prepared by different cyclodextrin ...

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Abstract

The invention relates to an inclusion compound containing rhizoma atractylodis arborinol, a medicinal combination and a preparation method thereof. The inclusion compound consists of rhizoma atractylodis arborinol, cyclodextrin and / or cyclodextrin derivative and the like. The inclusion compound is prepared through microwave radiation saturation aqueous solution together spray dehydration. In the inclusion compound, the mass ratio of rhizoma atractylodis arborinol to an inclusion material is 1: (3 to 30). The inclusion compound can be used for preparing various medicinal combinations such as tablets, suspensions and the like. The medicinal combination prepared from rhizoma atractylodis arborinol inclusion compound can significantly improve the dissoluation rate of rhizoma atractylodis arborinol in a dissolvent, thereby being favorable for improving bioavailability.

Description

technical field [0001] The invention relates to a medicinal intermediate of total terpene alcohol extract of Atractylodes atractylodis and a preparation method thereof. Specifically, it relates to an inclusion compound containing the total terpene alcohol extract of Atractylodes atractylodes and its preparation method; further, the present invention also relates to a pharmaceutical composition (pharmaceutical preparation) prepared from the inclusion compound. Background technique [0002] The present invention relates to a new preparation method of the pharmaceutical intermediate of the total terpene alcohol extract of Atractylodes atractylodes Rhizome described in Chinese patent application 200810239177.1 and its pharmaceutical composition. Therefore, Chinese patent application 200810239177.1 is incorporated in the description of the present invention as a reference. [0003] Traditional Chinese medicine data show that Atractylodes atractylodis has the effects of drying dam...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/284A61K47/48A61P1/12A61P1/14A61P11/00A61P17/00A61P27/02A61P29/00A61P31/00A61K47/69
Inventor 赵金华文震康晖梁慧
Owner 深圳海创医药科技发展有限公司
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