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Catheter tube and catheter comprising the tube

A catheter, isobutylene technology, applied in the direction of catheter, surgery, medical science, etc., to achieve the effect of good antithrombotic, improved operability and good operability

Active Publication Date: 2012-10-03
KANEKA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this kind of catheter (central venous indwelling catheter) has many problems that need to be improved depending on the forming material.

Method used

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  • Catheter tube and catheter comprising the tube
  • Catheter tube and catheter comprising the tube
  • Catheter tube and catheter comprising the tube

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] There is no particular limitation on the preparation method of the isobutylene-based block copolymer (A), for example, it can be obtained by the following method: in the presence of a compound represented by the following general formula (1), make a monomer component mainly composed of isobutylene and Polymerization of monomer components mainly composed of monomers other than isobutylene.

[0045] (CR 1 R 2 X) n R 3 (1)

[0046] In the formula, X is a substituent selected from a halogen atom, an alkoxy group or an acyloxy group with 1 to 6 carbon atoms, and R 1 , R 2 represent a hydrogen atom or a monovalent hydrocarbon group with 1 to 6 carbon atoms, R 1 , R 2 Can be the same or different, R 3 It is a multivalent aromatic hydrocarbon group or a multivalent aliphatic hydrocarbon group, and n represents a natural number of 1-6.

[0047] Using the compound represented by the above-mentioned general formula (1) as an initiator, in the presence of a Lewis acid or...

Embodiment 1～8

[0100] As the isobutylene-based block copolymer (A), a styrene-isobutylene-styrene block copolymer (hereinafter sometimes referred to as SIBS) "SIBSTAR 102T" (hereinafter abbreviated as 102T) manufactured by Kaneka Corporation was used. As the thermoplastic polyurethane resin (B) (hereinafter sometimes referred to as TPU), ether-based aromatic ring polyurethane "Miractran E385PNAT" (hereinafter referred to as E385) manufactured by Miractran Corporation of Japan, or TPU manufactured by Noveon Corporation was used. Ether-based alicyclic polyurethanes "Tecoflex EG100A" and "Tecoflex EG85A" (hereinafter abbreviated as EG100A and EG85A, respectively).

[0101] Each embodiment mixes 102T, E385, EG100A, and EG85A according to the mixing ratio shown in Tables 1 to 3, and supplies them from the feeding hopper of a twin-screw extruder in the same direction (manufactured by Toyo Seiki Co., Ltd., L / D=25.5) , the temperature near the feeding hopper of the same-direction twin-screw extruder...

Embodiment 9～11 and comparative example 5

[0117] Mix 102T and EG85A according to the mixing ratios shown in Tables 4 and 5 respectively, except that the inner and outer diameters of the tubes are respectively 0.90mm and 1.65mm, and the SIBS / TPU of Examples 9-11 are obtained in the same way as in Examples 1-8 Tube.

[0118] On the other hand, in Comparative Example 5, a tube was obtained in the same manner as in Comparative Example 4, except that the mixing ratios shown in Tables 4 and 5 were used, except that the inner and outer diameters of the tube were 0.90 mm and 1.65 mm, respectively.

[0119] (Antithrombotic evaluation test)

[0120] Each of the above-mentioned tubes was sterilized by EOG, and then cut into 30 cm lengths as test samples. In addition, in order to prevent flow blockage (bubble blockage) caused by air bubbles remaining in the tube during the experiment, the tube was filled with physiological saline in advance, and the tube was capped and used for the experiment. On the other hand, citric acid ant...

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Abstract

The present invention provides a catheter tube having excellent insertability into the body, excellent operability and an excellent anti-thrombogenic property, and also provides a catheter having the tube. A catheter tube comprises a mixture of an isobutylene block copolymer and a thermoplastic polyurethane resin, wherein the isobutylene block copolymer is composed of a polymer block mainly comprising isobutylene and a polymer block mainly comprising a monomeric component other than isobutylene; and a catheter using the tube.

Description

technical field [0001] The present invention relates to a catheter tube indwelled percutaneously in the body and a catheter using the catheter tube. Background technique [0002] Among the catheters placed in the body percutaneously, such as central venous catheters for administration of high-calorie infusions, they are usually inserted into blood vessels by puncture. That is, the insertion site is punctured with a needle, and the central venous catheter is inserted from the site to the superior vena cava called the central vein near the heart. After the tip of the catheter reaches the target site, a high-calorie infusion ( Patent Documents 1, 2). [0003] Patent Document 1: JP-A-2002-17860 [0004] Patent Document 2: JP-A-63-71259 Contents of the invention [0005] The problem to be solved by the invention [0006] In order to be easily inserted into the body (intravascular), the above-mentioned existing catheter (central venous indwelling catheter) is made of, for ex...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/00A61M25/00C08L53/00C08L75/04
CPCC08F297/00C08L53/025C08L75/08C08L53/02A61L29/049C08L53/00C08L75/04C08L2666/02C08L2666/14A61L31/00A61M25/00
Inventor 大原一将御林毅
Owner KANEKA CORP
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