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Siberian cocklebur fruit soft capsule for treating coryza, preparation method and quality control method thereof

A technology of cocklebur and soft capsules, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of lack of quantitative quality standard control, achieve quality control and curative effect, improve solubility, improve quality effect

Inactive Publication Date: 2009-07-01
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] The quality control test described is only a qualitative test, lacking an inherent practical and reliable quantitative quality standard control

Method used

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  • Siberian cocklebur fruit soft capsule for treating coryza, preparation method and quality control method thereof
  • Siberian cocklebur fruit soft capsule for treating coryza, preparation method and quality control method thereof
  • Siberian cocklebur fruit soft capsule for treating coryza, preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] Embodiment 1, preparation cocklebur rhinitis soft capsule

[0133] Weigh 30g of xanthium extract, 1.76g of gypsum extract powder, 41.4g of angelica extract powder, 48.1g of magnolia flower extract powder, 25.3g of scutellaria baicalensis extract powder, mix well, add 300g polyethylene glycol 400 and propylene glycol 27.5g, stir to mix and dissolve, set aside. Take another 30g of borneol, 4ml of magnolia flower volatile oil, and 15g of menthol, mix well, add to the above polyethylene glycol 400 mixture, mix, add polyethylene glycol 400 to a total weight of 550g, pass through a colloid mill, and put in a drum molding machine Molding in medium temperature for 3 hours, the molding conditions are temperature 27°C, relative humidity 20%, then wash the pellets with 95% ethanol, then put them on a drying tray to dry for 24 hours, the drying conditions are 26°C, humidity 20%, made into 0.55g / grain of soft capsules, ready to use.

Embodiment 2

[0134] Embodiment 2, preparation cocklebur rhinitis soft capsule

[0135] Weigh 30g of xanthium extract, 1.76g of gypsum extract powder, 41.4g of angelica extract powder, 48.1g of magnolia flower extract powder, 25.3g of scutellaria baicalensis extract powder, mix well, add 185g polyethylene glycol 400 and propylene glycol 27.5g, stir to mix and dissolve, set aside. Take another 30g of borneol, 4ml of magnolia flower volatile oil, and 15g of menthol, mix well, add to the above polyethylene glycol 400 mixture, mix, add polyethylene glycol 400 to a total weight of 450g, pass through a colloid mill, and put it in a drum molding machine Molding in medium temperature for 3 hours, the molding conditions are temperature 27°C, relative humidity 20%, then wash the pellets with 95% ethanol, then put them on a drying tray to dry for 24 hours, the drying conditions are 26°C, humidity 20%, pressed into 0.45g / grain of soft capsules, ready to use.

Embodiment 3

[0136] Embodiment 3, preparation cocklebur rhinitis soft capsule

[0137] Weigh 30g of xanthium extract, 1.76g of gypsum extract powder, 41.4g of angelica extract powder, 48.1g of magnolia flower extract powder, 25.3g of scutellaria baicalensis extract powder, mix well, add 500g polyethylene glycol 400 and propylene glycol 54g was stirred, mixed and dissolved, and set aside. Take another 30g of borneol, 4ml of magnolia flower volatile oil, and 15g of menthol, mix well, add to the above-mentioned polyethylene glycol 400 mixture, mix, add polyethylene glycol 400 to a total weight of 830g, pass through a colloid mill, and put it in a drum molding machine Molding in medium temperature for 3 hours, the molding conditions are temperature 27°C, relative humidity 20%, then wash the pellets with 95% ethanol, then put them on the drying tray to dry for 24 hours, the drying conditions are 26°C, humidity 20%, pressed into 0.83g / grain of soft capsules, ready to use.

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Abstract

The invention discloses a cocklebur fruit soft capsule for treating rhinitis, mainly composed of cocklebur fruit extractive powder, gypsum extractive powder, dahurian angelica extractive powder, bornel, magnolia flower volatile oil, menthol, magnolia flower extractive powder and scullcap extractive powder, and polyethylene glycol and propylene glycol as adjuvant. The invention also discloses a preparation method and quality control method thereof. The preparation method can improve the quality of the cocklebur fruit soft capsule for treating rhinitis and perform qualitative and quantitative quality control of soft capsule.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating rhinitis. Specifically, the invention relates to a cocklebur rhinitis soft capsule, a preparation method and a quality control method thereof. Background technique [0002] Rhinitis is a kind of common and frequently-occurring disease, adopts western medicine to treat and often index does not cure the root cause, recurs easily, is difficult to radical cure, and toxic and side effect is big. Therefore, most patients prefer to choose traditional Chinese medicine for treatment. Among them, a traditional Chinese medicine with better curative effect on rhinitis is Xanthiza rhinitis capsule, the prescription is recorded in "Chinese Medicine Prescriptions", Volume 12, page 57, "Xangerzi rhinitis capsule", standard number: WS3-B-2701 -97. The prescription is as follows: [0003] Xanthium extract 180g Gypsum extract powder 1.76g Angelica dahurica extract powder 62.1g [0004] Borneol 30g M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/575A61K9/48A61P11/02A61K31/045A61K33/06
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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