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Induction of weight loss and the selective inhibition of PTP1B

A technology for weight loss and carrier, which is applied in the directions of medical preparations containing active ingredients, organic active ingredients, pharmaceutical formulations, etc., can solve problems such as the difference that does not show inhibitory activity, etc.

Inactive Publication Date: 2009-07-01
吉纳拉公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] Although various agents have been identified as PTP1B inhibitors, such as the heteroaryl-glycine and aryl-glycine described in WO 01 / 19831, WO 01 / 19830 and WO 01 / 17516, these agents do not exhibit Differences in inhibitory activity between PTP1B and TCPTP

Method used

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  • Induction of weight loss and the selective inhibition of PTP1B
  • Induction of weight loss and the selective inhibition of PTP1B
  • Induction of weight loss and the selective inhibition of PTP1B

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Embodiment 3

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Abstract

The present invention is directed to the use of compound 1436 for the induction of weight loss in an obese mammal.

Description

technical field [0001] The present invention is directed to the use of compound 1436 in inducing weight loss in obese mammals. Background technique [0002] Several aminosterol compounds have been isolated from the liver of the dogfish shark, Squalus acanthias. One of these compounds has been named 1436 and its structure is shown in figure 1 middle. Compound 1436 has been previously described in, for example, U.S. Patents 5,763,430, 5,795,885, 5,847,172, 5,840,936, and 6,143,738, all of which are incorporated in their entirety, and Compound 1436 has been shown to inhibit weight gain and suppress appetite in animal models, lead to weight loss. [0003] Obesity is a major medical problem in the United States and increasingly in other developed societies as well. The reason is mainly due to the influence of lifestyle and diet rich in fat. Obese individuals are predisposed to medical problems directly related to their obesity, such as type II diabetes, insulin resistance, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P3/10A61P3/04
Inventor 迈克尔·迈克莱恩克里斯滕·A·兰茨苏珊·G·伊迈哈特安德鲁·V·阿尔布莱特洪晓玲亨利·R·伍尔夫
Owner 吉纳拉公司