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Preparation method of forsythoside-beta-cyclodextrin inclusion compound

A technology of cyclodextrin inclusion compound and forsythiaside, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of poor stability and easy oxidation, etc. Achieve the effect of low production cost and simple process

Inactive Publication Date: 2009-07-08
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Forsythiaside is a derivative of caffeic acid, its molecular structure has ester bonds and multiple phenolic hydroxyl groups, and it is prone to oxidation, so its stability is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh β-CD30g and 10g of forsythiaside extract with a purity of 60% in a colloid mill, add ethanol-containing 30% citric acid-sodium citrate buffer solution with a pH of 4.5, grind for 15min, filter under reduced pressure, and use The inclusion compound was washed with absolute ethanol, and dried in vacuum to obtain 29.2 g of the inclusion compound. The content of forsythiaside in the inclusion compound of forsythiaside-β-cyclodextrin is 18.1%, the inclusion rate of forsythiaside is 88.0%, and the yield of inclusion compound is 73.0%.

Embodiment 2

[0024] Weigh β-CD30g and 10g of forsythiaside extract with a purity of 60% in a colloid mill, use a citric acid-sodium citrate buffer solution containing 20% ​​ethanol at a pH of 6, grind for 20min, filter under reduced pressure, and use The inclusion compound was washed with absolute ethanol, and dried in vacuum to obtain 28.0 g of the inclusion compound. The forsythiaside content in the forsythiaside-β-cyclodextrin inclusion compound is 18.3%, the forsythiaside inclusion rate is 85.5%, and the inclusion compound yield is 70.0%.

Embodiment 3

[0026] Weigh 40 g of β-CD and 10 g of forsythiaside extract with a purity of 50% in a colloid mill, use acetic acid-sodium acetate buffer solution containing 30% ethanol at a pH of 6, grind for 15 min, filter under reduced pressure, and use The inclusion compound was washed with water and ethanol, filtered under reduced pressure, and vacuum-dried to obtain 36.0 g of the inclusion compound. The forsythiaside content in the forsythiaside-β-cyclodextrin inclusion compound is 12.1%, the forsythiaside inclusion rate is 87.0%, and the inclusion compound yield is 72.0%.

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PUM

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Abstract

The invention provides a method for preparing a forsythoside-beta-cyclodextrin inclusion compound. Forsythoside extract with the purity of 50%-60% is used as raw material, and the forsythoside-beta-cyclodextrin inclusion compound is prepared by a colloid mill inclusion method. The content of the forsythoside in the forsythoside-beta-cyclodextrin inclusion compound is 10%-20%, the inclusion ratio of the forsythoside is more than 85 percent, and the inclusion compound yield is more than 70 percent.

Description

Technical field: [0001] The invention relates to an inclusion compound of active ingredients of traditional Chinese medicine, in particular to a preparation method of a forsythiaside-β-cyclodextrin inclusion compound. Background technique: [0002] The traditional Chinese medicine Forsythia is the dried fruit of Forsythia suspensa (Thunb.Vahl)]. Forsythia is mainly produced in Shanxi, Henan, Shaanxi, Shandong and other places in my country. Forsythiaside, as a main active ingredient rich in forsythia, has various biological activities, such as antifungal, antiviral, antiinfective, antipyretic and elastase inhibitory. In particular, it has strong antioxidant activity and is expected to be developed as a natural antioxidant. [0003] β-cyclodextrin (β-CD) inclusion technology is a new technology in the development of modern pharmaceuticals, and it is a new type of drug inclusion material that has attracted much attention in recent years, mainly because β-CD has a special mol...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/7048A61P29/00A61P31/00A61P31/10A61P31/12A61P39/06A61K47/69
Inventor 张立伟王引珍
Owner SHANXI UNIV
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