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Method of preparing particles for agglomeration

A technology of granules and salt granules, which is applied in the field of agglomerates and the formation of said agglomerates, which can solve the problems of repeatable production without precise control of particle size distribution

Inactive Publication Date: 2009-07-15
MERCK & CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, there is as yet no method for the reproducible production of drug and / or solid carrier particles with precise control of particle size distribution and amorphous content

Method used

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  • Method of preparing particles for agglomeration
  • Method of preparing particles for agglomeration
  • Method of preparing particles for agglomeration

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Embodiment Construction

[0025] specific implementation plan

[0026] According to the present invention, the term "pharmaceutically acceptable substance" includes pharmaceutically active substances or non-pharmaceutically active substances. Pharmaceutical active substances are drugs, vitamins, minerals, herbs, and food fortifications, etc., which produce a therapeutic effect when administered to a patient in need of such treatment. Non-pharmaceutically active substances include solid carriers, solid binders and other conventional pharmaceutically acceptable excipients which generally do not exhibit a therapeutic effect when administered to a patient as part of a formulation. "Agglomerate" in the present invention generally refers to the agglomeration of smaller particles to form larger particles. These smaller particles can be held together by conventional binders or by crystallization of the transformable amorphous material produced by the process of the invention.

[0027] "Amorphous substance" a...

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Abstract

Methods of preparing particulates for agglomeration, having a specified particle size distribution and desired convertible amorphous content, are described. The method involves a plurality of micronizing steps at least two of which are separated by a curing step. In the curing step, a stimulus such as humidity may be used to crystallize at least some, and in many instances preferably all, of the convertible amorphous content.

Description

[0001] This application is a divisional application filed on January 27, 2000, the application number is 00803049.9, and the title of the invention is "Method for Preparing Agglomerated Particles". technical field [0002] Broadly speaking, the present invention relates to the formation of agglomerates, to particulate solid carriers and / or binders and / or pharmaceutically active substances for forming the agglomerates, to methods of forming said agglomerates and Agglomerates thus formed. [0003] In particular, the present invention relates to the field of pharmaceutical dosage form design, particularly the preparation of unique solid carriers and / or pharmaceutically active substances and agglomerated dosage forms for administering the pharmaceutically active substances to patients. Background technique [0004] Several methods of treating diseases and conditions of the upper and lower airways and lungs are known. These indications include, for example, asthma and rhinitis. ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/58A61P29/00A23P1/02A61K9/00A61K9/16A61K9/72A61K31/137A61K31/167A61K45/00
CPCA61K9/145A61K31/167A61K31/58A61K9/0075A61K9/1623A61P11/02A61P11/06A61P29/00
Inventor T·-T·杨S·K·C·于C·G·埃克哈特M·B·米切尔
Owner MERCK & CO INC