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Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone

A technology for releasing compositions and hydrocodone, which can be used in drug combinations, medical preparations containing active ingredients, drug delivery, etc., and can solve problems such as addiction

Inactive Publication Date: 2009-07-15
ELAN PHRMA INT LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0037] The problem with using traditional hydrocodone formulations is that they can be addictive

Method used

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  • Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone
  • Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone
  • Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0262] The purpose of this example is to describe a multiparticulate modified release composition containing hydrocodone that can be used in the binding composition of the present invention.

[0263] According to the formulations shown in Tables 1 and 2, the multiparticulate modified release hydrocodone composition with immediate release ingredients and modified release ingredients (with modified release coating) according to the present invention was prepared.

[0264] Table 1

[0265] Hydrocodone solution

[0266]

[0267] Table 2

[0268] Modified release component hydrocodone solution

[0269]

[0270] In these exemplary hydrocodone formulations, sugar spheres (30 / 35 mesh) are provided as an inert core that acts as a carrier for the active ingredients and other excipients present in the formulation. The amount and size of the selected sugar spheres should reflect the requirement that the average diameter of the multi-particles produced is within the size range of 0.5-0.6 m...

Embodiment 2

[0295] The purpose of this example is to describe the preparation of a naproxen composition that can be used in the conjugate composition of the present invention.

[0296] Using a continuous laboratory mixer, 30 g of hydroxypropyl cellulose (Klucel Type EF; Aqualon) was dissolved in 670 g of deionized water. 300 g of naproxen was dispersed into the HPC solution until a uniform suspension was obtained. A laboratory scale media grinder filled with polymer grinding media was used in continuous mode until the average particle size was about 200 nm (as measured by laser light scattering technology ex. Microtrak UPA).

Embodiment 3

[0298] The purpose of this example is to describe the preparation of a naproxen composition that can be used in the conjugate composition of the present invention.

[0299] Using a continuous laboratory stirrer, 25 g polyvinylpyrrolidone (K29 / 32; BASF Corp 1) was dissolved in 575 g deionized water. 400g of naproxen was dispersed into the PVP solution until a uniform suspension was obtained. It is processed in a continuous mode by a laboratory-scale media grinder filled with polymer grinding media until the average particle size is approximately 200 nm (as measured by laser light scattering technology ex. Microtrak UPA).

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Abstract

The invention relates to a compositions comprising a nanoparticulate naproxen composition in combination with a multiparticulate modified release hydrocodone composition that, upon administration to a patient, delivers a hydrocodone in a bimodal or multimodal manner. The multiparticulate modified release composition comprises a first component and at least one subsequent component; the first component comprising a first population of hydrocodone - comprising particles and the at least one subsequent component comprising a second population of hydrocodone-comprising particles, wherein the combination of the components exhibit a bimodal or multimodal release profile. The invention also relates to a solid oral dosage form comprising such a combination composition.

Description

[0001] Cross-references to related applications [0002] This application claims the priority of provisional application No. 60 / 815,885 filed on June 23, 2006, and this application is a partial continuation application of application No. 11 / 372,857 filed on March 10, 2006, and April 2004 Part of the continuation application of Application No. 10 / 827,689 filed on January 19, of which, Application No. 10 / 827,689 is the application No. 10 / 354,483 (now U.S. Patent No. 6,793,936) filed on January 30, 2003 Application for continuation. Application No. 10 / 354,483 is a continuation application for Application No. 10 / 331,754 (now U.S. Patent No. 6,902,742) filed on December 30, 2002. Application No. 10 / 331,754 is May 2001 Application No. 09 / 850,425 (now U.S. Patent No. 6,730,325) filed on the 7th is the continuation application, and Application No.09 / 850,425 is the application No. 09 / 566,636 filed on May 8, 2000 (now U.S. Patent No. No. 6,228,398). Application No.09 / 566,636 is the continuati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K31/12A61K9/22
CPCA61K9/5078A61K9/2081A61K9/2054A61K31/485A61K9/2018A61K9/2077A61P11/14A61P19/02A61P25/04A61P29/00A61P43/00A61K31/192
Inventor P·斯塔克J·德韦恩N·范宁G·里弗斯德格S·简金斯G·辛格-雷克伊
Owner ELAN PHRMA INT LTD
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