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Electrode introducer device

An introducer, electrode technology, applied in the direction of heating surgical instruments, etc.

Inactive Publication Date: 2011-06-08
REGION HOVEDSTADEN VHERLEV HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is therefore clear that the mentioned prior art devices are only well suited for treatments in target areas in close proximity to the outer surface of the body, since an attempt to treat deeper areas would cause excessive trauma of the intervening tissue

Method used

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  • Electrode introducer device
  • Electrode introducer device
  • Electrode introducer device

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0051] figure 1 The electrodes introduced into the electroporation device 1 according to an embodiment of the present invention are shown in . The device 1 comprises a handle portion 100 and an elongated introducer shaft 10, preferably of a length suitable for accessing deeper tissue regions. The length of shaft 10 may be suitable for the intended use. The shaft 10 is connected to the handle portion 100 and has a distal end 11 and a proximal end 12 adjacent the handle portion 100 . The shaft may in one embodiment be fixedly connected to the handle portion. In other embodiments, the shaft is removably mounted to the handle portion 100, and may include suitable means for establishing a temporary connection, such as for conducting electrical impulses. Disposed at the distal end 11 of the shaft 10 is a distal tip 13 preferably shaped to allow passage through interlayers of tissue while causing minimal damage to said tissue. . The distal tip 13 has a round non-cut shape. In o...

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PUM

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Abstract

An electroporation device 1 comprising a handle section 100; an elongate introducer shaft 10 connected to said handle section 100, said introducer shaft 10 having a distal tip 13; and a set of electrodes 60 having respective distal ends 61, each electrode 60 being slidably arranged within said introducer shaft 10 from a retracted position, where said distal ends 61 are enclosed within said introducer shaft 10, to an exposed position, where said distal ends 61 extend from said distal tip 13; wherein said electrode distal ends 61 are deflectable away from a longitudinal axis L of said shaft 10 when deployed / extended to their extended position, such that at least one planar projection taken in a plane perpendicular to said longitudinal axis L of a distance D1 between a pair of distal ends 61of said electrodes 60 is larger than a maximal extent D2 of a cross-section of said introducer shaft 10, said cross-section taken in a plane perpendicular to said longitudinal axis L at a distal end 11 of said introducer shaft 10.

Description

technical field [0001] The present invention relates to devices and methods for electroporation, and generally and more particularly to methods for enhancing the response to, for example, drugs, isotopes or Devices and methods for the administration of therapeutic molecules such as genetic materials. Background technique [0002] In the treatment of disease in the brain, such as brain cancer, and disease in other anatomical regions of the body, physical access to diseased tissue regions can be a challenge. This is especially a problem if the diseased area is located deep within the patient's body. Furthermore, efficient delivery and subsequent uptake of therapeutic molecules, such as pharmaceutical or genetic compounds, to target tissues of anatomical structures is often a problem. [0003] Electroporation is a known method for delivering pharmaceuticals and genetic material to various physiological tissues, wherein the uptake of these substances into tissue cells is enhan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B18/14
Inventor 卡伦·朱莉·格尔卡斯滕·维泽贝克
Owner REGION HOVEDSTADEN VHERLEV HOSPITAL