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Radiation device for photodynamic therapy

A technology of photodynamic therapy and irradiation device, which is applied in the direction of irradiation device, phototherapy, and photosensitive materials used in photomechanical equipment, etc., which can solve the problems of reduced incident efficiency, light incident angle difference, incident uniformity, etc.

Inactive Publication Date: 2009-09-02
BEYOND INNOVATION TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the refractive index of skin, muscle, organs and other tissues (hereinafter referred to as tissue) is mostly around 1.4 ( Figure 4B ), significantly larger than air (refractive index = 1), light will be reflected and scattered on the surface of the tissue, resulting in a significant decrease in incident efficiency
On the other hand, the topography of the tissue surface is often non-planar, resulting in unpredictable changes in the incident angle of light, affecting the incident rate and resulting in poor incident uniformity

Method used

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  • Radiation device for photodynamic therapy
  • Radiation device for photodynamic therapy
  • Radiation device for photodynamic therapy

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Embodiment Construction

[0057] Please refer to Figure 6 It is the first preferred embodiment of the irradiation device for photodynamic therapy (Photodynamic Therapy, PDT) of the present invention. The irradiation device of this embodiment is used to irradiate a tissue that is given a rhodopsin family photosensitizer or its precursor 605 606. The irradiation device of this embodiment may include a light emitting diode (LED) light source 601, a power supply and control circuit 602, a reflector 603 and an optical mirror 604, wherein the light emitted by the light emitting diode 601 passes through the reflector 603 and the optical lens 604 project light onto the administered tissue 606 (for example, it may be a rhodopsin family photosensitizer or its precursor 605). Wherein, the light emitting diode 601 may be an aluminum gallium indium nitride (AlInGaN) light emitting diode. Among them, porphyrin (also known as porphyrin) photosensitizer or its precursor 605 refers to any compound containing porphin...

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Abstract

The invention relates to an effective radiation device for photodynamic therapy. The radiation device collects the optimum absorptive wavelength of sclererythrin (also called porphyrin) family photosensitizer at the position close to 405 nm, and utilizes the optical characteristic of tissue, especially deep tissue, and the characteristic of optical interface changing and the like to overcome the difficulty that the emission wavelength within the range is uneasy to deeply penetrate the tissue.

Description

technical field [0001] The invention relates to an irradiation device for photodynamic therapy, in particular to an irradiation device for photodynamic therapy which is suitable for deep tissue and has the maximum luminous efficiency near the wavelength of about 405nm. Background technique [0002] The basic principles of current photodynamic therapy (see figure 1 ) is to use the light-sensitive substance contained in the diseased tissue (such as acne bacteria in acne) or apply the light-sensitive substance locally or intravenously to the patient, and then irradiate the diseased tissue with light of a specific wavelength (usually red light), At this time, the light energy will be transferred to other substances in the tissue through the light-sensitive substance, and photochemical action will occur, and then produce toxic molecules to the cells to kill tumor cells or other lesions. Since the basic components of photodynamic therapy are photosensitive substances and excitati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/06G03F7/004G21K5/00
Inventor 徐智鹏包又菘林久渊
Owner BEYOND INNOVATION TECH
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