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Selective dopamine D4 receptor agonists used for treating sexual disorder

A receptor agonist, dopamine technology, applied in the field of selective dopamine D4 receptor agonist, can solve the problem of undetermined therapeutic efficacy

Inactive Publication Date: 2009-09-09
ABBOTT LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is not confirmed as D 4 Compounds that are selective agonists have clear therapeutic utility

Method used

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  • Selective dopamine D4 receptor agonists used for treating sexual disorder

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Embodiment Construction

[0017] All references included herein are hereby incorporated by reference in their entirety.

[0018] In its main embodiment, the present invention relates to a method of treating sexual dysfunction comprising administering a therapeutically effective amount of dopamine D 4 A receptor agonist or a pharmaceutically acceptable salt or prodrug thereof, wherein said compound is other than apomorphine (5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de, g] quinoline-10,11-diol). The present invention relates to a method of treating male sexual dysfunction including, but not limited to, erectile dysfunction and premature ejaculation, the method comprising administering a therapeutically effective amount of dopamine D 4 Receptor agonists or pharmaceutically acceptable salts or prodrugs thereof. The present invention also relates to a method of treating female sexual dysfunction including, but not limited to, female anhedonia, clitoral inadequacy, vaginal engorgement, dyspareunia, and vagi...

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Abstract

The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction.

Description

[0001] The application date is November 21, 2001, the national application number is 01819205.X (the international application number is PCT / US01 / 43139), and the invention name is "selective dopamine D4 receptor agonist for the treatment of sexual dysfunction" divisional application of the application. technical field [0002] The present invention relates to selective dopamine D 4 Use of receptor agonists and selective dopamine-containing D for the treatment of sexual dysfunction 4 Compositions of receptor agonists. Background technique [0003] The relaxation and erection of the penis are determined by the tone of the smooth muscle of the corpus cavernosum. The muscle tone is controlled by coordinated integrated biochemical events at the peripheral and central nervous system levels. Sympathetic, parasympathetic, and somatic nerves control cavernous tone through neuroanatomical connections that are an important part of lower urinary tract innervation. [0004] Penile er...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/496A61P15/10A61P15/02A61KA61P
Inventor J·D·布里奥尼T·科拉萨G·C·希D·L·多内利-罗伯茨D·L·多内利－罗伯茨
Owner ABBOTT LAB INC
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