Devices and bandages for treatment or prevention of scars and/or keloids and methods and kits therefor

A technology for bandages, scars, applied in the field of scar treatment and improvement of scar formation

Active Publication Date: 2013-10-23
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Perhaps the biggest drawback is that none of these methods are effective in preventing or improving scarring or scarring in the first place

Method used

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  • Devices and bandages for treatment or prevention of scars and/or keloids and methods and kits therefor
  • Devices and bandages for treatment or prevention of scars and/or keloids and methods and kits therefor
  • Devices and bandages for treatment or prevention of scars and/or keloids and methods and kits therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Example 1 Examples of Stress Can Cause or Promote Hypertrophic Scar Formation

[0098] Four week old C5 / BL6 mice were housed under standard protocols approved by the New York University Animal Care and Use Committee. Construct as Figure 17 The mechanical tensioning device 1700 is shown schematically in FIG. The expansion bolts 1790 were secured to the plate supports 1792 by plastic interfaces and clear resin (not shown, available from Devcon Scientific, Riviera Beach, FL, which can be dried overnight). Such as Figure 18-19 Two 2 cm linear full-thickness incisions (1802, 1802', 1902, 1902') were made 1.25 cm apart along the length of each mouse's back (1810, 1910) as shown schematically in . The incision is closed with 6-0 nylon sutures. On the fourth day after incision, during the proliferative phase of the wound healing process, the sutures were removed.

[0099] Such as Figure 18 As shown, two mechanical tensioning devices 1800, 1800' are attached to the rat'...

Embodiment 2

[0103] Example 2 Preparation of Exemplary Device or Bandage

[0104] T will be available from MedShape Solutions, Inc., 900 Anaconda Court, Castle Rock, CO g Acrylic-based shape memory polymer Memori with values ​​at 20°C, 30°C and 40°C TM The System's polymer sheet is cut into rectangular, generally flat, flexible bandages - with in-plane dimensions of approximately 45mm x 20mm. to T g Sheets made of polymers with a value of 20° C. have a thickness of approximately 200 microns and 500 microns. to T g The thickness of a sheet made of a polymer with a value of 30°C is about 500 microns; g Sheets made of polymers with a value of 40° C. have a thickness of about 1000 microns. Each of the first set of eight bandages is held individually between clamping structures and heated to a temperature greater than the T of the polymer used in the bandage. g High temperature of about 60°C to 90°C. By translating the clamping structure away at a speed of approximately 1 mm / min, the g...

Embodiment 3

[0109] Example 3 Preparation of Exemplary Device or Bandage

[0110] Silicone polymer sheets MED 82-5010-05, MED 82-5010-10, and CSM 82-4032-20, available from NUSIL TECHNOLOGY LLC, 1050 Cindy Lane, Carpinteria, CA 93013 USA, were cut into rectangular, generally flat, flexible bandages - Its in-plane dimensions are approximately 50 mm x 40 mm. MED 82-5010-05 and MED 82-5010-10 sheets had a hardness value of 50 and a thickness of approximately 120 microns and 230 microns, respectively. The CSM82-4032-20 sheet has a hardness value of 30 and a thickness of approximately 490 microns.

[0111] An additional silicone polymer sheet HT6240, available from Stockwell Elastometrics, Inc., 4749 Tolbut St., Philadelphia, PA 19136, USA, was cut into rectangular, generally flat, flexible bandages - with in-plane dimensions of approximately 50mm x 40mm. The HT6240 sheet had a hardness value of 40 and a thickness of approximately 500 microns.

[0112] Next, MED 1356 pressure sensitive adhes...

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Abstract

Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and / or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and / or exogenous stress.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application No. 60 / 835,654, filed August 3, 2006, which is hereby incorporated by reference in its entirety. technical field [0003] The devices, kits and methods described herein relate to the field of wound healing, in particular, to the treatment of scars and the improvement of scar formation. For example, the devices, kits and methods described herein may be used in the treatment, amelioration or prevention of scars and / or cicatrixes. Background technique [0004] Scars form from trauma to the skin as part of the natural wound healing process. Wound healing is a long-term and continuous process, although it is generally considered to occur in stages. The process begins with an inflammatory phase immediately after trauma. During this phase, which usually lasts from two days to a week (depending on the wound), damaged tissue and foreign objects are removed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/12C08L25/00C08F20/00A61K38/16A61K47/48C07K5/06C07K5/072C07K5/083C07K5/103C07K7/02C07K9/00C12NG01N33/574
CPCA61L2300/428A61L15/42A61L15/44A61L15/58A61L2300/412A61F13/00A61F2013/0037A61K38/00A61K47/64A61K47/67B82Y5/00C07K5/0606C07K5/06113C07K5/0806C07K5/081C07K5/1008C07K7/02C07K9/005G01N33/57407G01N33/57419G01N2333/95G01N2500/00A61L15/12C08F20/00C08L25/00A61F13/02A61F13/00051A61F13/00059A61F13/0233A61F13/0243A61F2013/00123A61F2013/00127A61F2013/00153A61F2013/00182A61F2013/0028
Inventor G·C·居尔特内R·H·道斯卡特M·T·朗埃克P·约克
Owner THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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