Pharmaceutical composition and preparation method thereof

Abstract

The invention discloses a pharmaceutical composition, in particular a pharmaceutical composition prepared by adopting a prescription medicine originated from a traditional Chinese medicine pill and an ultrafine grinding technology, and a preparation method thereof. The preparation method induces an auxiliary material ultrafine grinding technology, thereby enabling mineral medicines to have smaller granularity and greatly increased specific areas, ensuring that medicinal materials from animals and plants have over 90 percent of cell shell-broken rate after being ground in an ultrafine way, active ingredients in the cells can be better exposed to be in a release condition, and the dissolution rate and the bioavailability of the active ingredients are greatly enhanced, maintaining the compound grinding homogenization and fully embodying the traditional Chinese medicine features. The preparation has the advantages that the dissolution rate of the active ingredients is high, the dissolution time is short, the absorption and the utilization are full, the curative effect is good, the production cycle is short, the production cost is low, and the like, thereby having wide market prospect and further satisfying and guaranteeing the requirements of people on medicines.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition prepared by ultrafine pulverization technology for prescription medicinal flavors derived from traditional Chinese medicine pills, and the prepared preparations are pills, tablets or capsules, belonging to the field of traditional Chinese medicines. Background technique [0002] Pills are one of the traditional dosage forms of traditional Chinese medicine. As early as in "Fifty-two Disease Prescriptions", there are descriptions of the name, prescription, specification, dosage and administration method of pills. There are 788 prescriptions recorded in "Taiping Huimin Heji Bureau Prescription" in Song Dynasty, of which 284 are pills, accounting for 36%. "Treatise on Febrile and Miscellaneous Diseases" and "Golden Chamber Yaolue" have recorded that honey, sugar, starch paste, and animal medicine juice were used as pill binders, and pill coatings began to a...

AI Technical Summary

Problems solved by technology

There are many deficiencies in the traditional preparation process of the above-mentioned pills: ①The dissolution rate of active ingredients is low, which greatly affects its absorption and utilization and clinical efficacy; It affects the pill forming process, and most of the obtained pills do not meet the requirements in terms of appearance and weight difference; ③The particle size of the fine powder of the drug is relatively large, most of which are about 80 mesh (about 180 μm), the bioavailability of the active ingredients is low, and the resources of Chinese medicinal materials are wasted The phenomenon is serious; ④ The pills take a long time to dissolve and disperse, and most of them are close to or even exceed 60 minutes, which does not meet the requirements of the Pharmacopoeia; ⑤ The production efficiency is low, the production cycle is long, and the production cost is correspondingly increased.

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