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Stable liquid curbitacin preparation and method for preparing same

A technology of liquid preparation and cucurbitacin, which is applied in the direction of liquid transportation, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems that it is difficult to meet the needs of pharmaceuticals and preparations, and the solubility of cucurbitacin is limited. , to achieve the effect of increasing solubility and improving solubility

Inactive Publication Date: 2009-11-18
BEIJING SHENKELIANHUA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dissolution of cucurbitacin by medium-chain triglycerides is still limited, which is difficult to meet the needs of pharmaceuticals and preparations

Method used

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  • Stable liquid curbitacin preparation and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1. Recipe: Cucurbitacin: 1g Duck Gallbladder Oil: 200g

[0049] 2. Preparation method: Add the prescribed amount of cucurbitacin into the duck gall oil, and stir while adding until the cucurbitacin is completely dissolved. Get the prepared cucurbitacin liquid preparation, add 200g of polyoxyethylene castor oil (emulsifier), and emulsify with an ultrasonic emulsifier to obtain cucurbitacin fat emulsion.

Embodiment 2

[0051] 1. Recipe: Cucurbitacin: 2.5g Duck Gallbladder Oil: 350g

[0052] 2. Preparation method: Add the prescribed amount of cucurbitacin into the duck gall oil, and stir while adding until the cucurbitacin is completely dissolved. Take the prepared cucurbitacin liquid preparation, add 200g of filler microcrystalline cellulose and 200g of dextrin, mix evenly, and then granulate, add an appropriate amount of magnesium stearate lubricant to compress into tablets, and then get cucurbitacin tablets. Co-production of cucurbitacin Tablets 1000 pieces.

Embodiment 3

[0054] 1. Recipe: Cucurbitacin: 100g Duck Gallbladder Oil: 100g

[0055] 2. Preparation method: Add the prescribed amount of cucurbitacin into duck gall oil, stir while adding, add 50g of hydroxypropyl cellulose and 100g of dextrin, mix evenly, and then make granules, add an appropriate amount of lubricant talcum powder, and make tablets together. Cucurbitacin tablets 1000 pieces.

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Abstract

The invention relates to a stable liquid curbitacin preparation which contains curbitacin and Brucea javanica oil and can also contain other liquid fatty oil and / or antioxidant. The invention also relates to a medicament taking the stable liquid curbitacin preparation as an active component. The medicament can be the injection, the oral medicament, the dropping pill, the emulsion, the soft capsule, the hard liquid capsule or the suspension. The stable liquid curbitacin preparation has the efficacy of treating the hepatitis, the cirrhosis, the tumour, the cancer and the like; the curbitacin and the Brucea javanica oil can interact synthetically; and the Brucea javanica oil can well solve the curbitacin and prevent the curbitacin from being oxidized.

Description

technical field [0001] The present invention relates to a kind of stable cucurbitacin liquid preparation, specifically, relate to the cucurbitacin liquid preparation comprising cucurbitacin and duck gall oil, the present invention also relates to a kind of medicine with said liquid preparation as active ingredient, and their use Medical use in chronic hepatitis, liver cirrhosis, tumor, cancer. It belongs to the field of medicine. Background technique [0002] Cucurbitacin is a class of tetracyclic triterpenoids, usually extracted from Cucurbitaceae, Brassicaceae, Scrophulariaceae, Begoniaceae, Duyingaceae, Tetraphyllaceae, and some large fungi. Cucurbitacin mainly contains cucurbitacin B, cucurbitacin E, isocucurbitacin B, dihydrocucurbitacin B, etc. In ancient my country, the melon pedicle of the Cucurbitaceae plant melon was used to treat jaundice, and it can also induce vomiting and eliminate phlegm, and it is used for phlegm and saliva. Since the 1960s, with the estab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/48A61K9/20A61K9/10A61K9/08A61K9/107A61K47/34A61K47/38A61K47/24A61P1/16A61P35/00A61K31/575A61K31/22A61K47/14A61K47/44
Inventor 申静
Owner BEIJING SHENKELIANHUA TECH
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