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Application of alfa-ketoglutaric acid iron in preparing iron-filling drug and health care product

A technology of iron ketoglutarate and iron deficiency anemia, which is applied in the field of medicine, can solve the problems of restriction, severe gastrointestinal reactions, and low bioavailability, and achieve the goal of improving anemia and promoting the body's material and energy metabolism Effect

Inactive Publication Date: 2009-11-25
BEIJING JIASHILIANBO PHARM SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, oral administration of soluble compounds such as ferrous sulfate and ferrous gluconate has been used as the most important means of controlling iron deficiency worldwide, but long-term time has proved that when this prevention method is used as a public health strategy, its application The effect is unsatisfactory, the reason is that iron treatment has shortcomings such as low bioavailability and heavy gastrointestinal reactions, and the gastrointestinal reactions of iron make some administration subjects unable to persist or refuse to take iron, making it difficult to be used in clinical practice. applications on the

Method used

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  • Application of alfa-ketoglutaric acid iron in preparing iron-filling drug and health care product
  • Application of alfa-ketoglutaric acid iron in preparing iron-filling drug and health care product
  • Application of alfa-ketoglutaric acid iron in preparing iron-filling drug and health care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Alpha-Ketoglutarate Iron Tablets

[0043] Formula: α-ketoglutarate iron 2.5kg, starch 0.4kg, sugar powder 0.2kg, carboxymethyl starch sodium 0.03kg, magnesium stearate 0.015kg, 10% starch slurry 1.5kg.

[0044] Preparation method: Take α-ketoglutaric acid iron raw material, starch, powdered sugar, grind them separately, mix them evenly, granulate with 10% starch slurry, dry, then add carboxymethyl starch sodium and magnesium stearate respectively, mix Uniformly, compressed into tablets, coated, that is to say.

Embodiment 2

[0046] Alpha-ketoglutarate iron capsules

[0047] Preparation method: Take 3 kg of α-ketoglutarate iron and 0.2 kg of dextrin, mix well, granulate with 10% starch slurry, dry, add 0.025 kg of magnesium stearate, stir evenly, put into capsules, and obtain.

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Abstract

The invention discloses a novel iron-filling agent, which is mainly made of alpha-ketoglutaric acid iron. The drug has obvious effect of treating iron deficiency anemia, nutritional anemia, hemorrhagic anemia and aplastic anemia, and can also be used for auxiliary treatment of anemia. The medicament has the function of obviously improving blood cells of animals and the anemia of human body, and compared with the similar blood-enriching product, the medicament has the advantages of high bioavailability, little irritation on the gstrointestinal tract, low price, obvious healing effect and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of iron α-ketoglutarate in drugs or health products for treating or preventing iron deficiency diseases. Background technique [0002] Anemia is a common disease, frequently-occurring disease. Most anemia is iron deficiency anemia (irondeficiency anemia, IDA). Iron deficiency anemia is a common nutritional deficiency. It is a nutritional anemia caused by the body's increased need for iron, or the body's absorption and utilization of iron. It is typically characterized by small cell hypochromia. The prevalence of iron deficiency anemia is quite high especially in developing countries. [0003] At present, it is believed that the most important causes of IDA are unreasonable food mix, rapid weight gain (such as infancy and rapid puberty), heavy menstrual bleeding, pregnancy, frequent blood supply, continuous super-intensive training, and long-term use...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61P3/02A61P7/06
Inventor 赵锋刘文尧
Owner BEIJING JIASHILIANBO PHARM SCI & TECH