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Application of sodium houttuyfonate in preparing medicament for preventing and treating myocardial hypertrophy and/or ventricular hypertrophy

A technology of houttuyfonate sodium and myocardial hypertrophy, which is applied in the direction of drug combination, pharmaceutical formula, cardiovascular system diseases, etc., to achieve the effect of preventing or heart failure, inhibiting activation, and having a large safety range

Inactive Publication Date: 2010-01-06
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports and applications of houttuynia cordata and houttuyniatin sodium on the prevention and treatment of cardiac hypertrophy and ventricular hypertrophy.

Method used

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  • Application of sodium houttuyfonate in preparing medicament for preventing and treating myocardial hypertrophy and/or ventricular hypertrophy
  • Application of sodium houttuyfonate in preparing medicament for preventing and treating myocardial hypertrophy and/or ventricular hypertrophy
  • Application of sodium houttuyfonate in preparing medicament for preventing and treating myocardial hypertrophy and/or ventricular hypertrophy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Anti-isoproterenol induced mouse ventricular hypertrophy experiment

[0019] 1.1 Experimental animals: Kunming mice, weighing 20-22 g; purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences, and raised in the SPF laboratory of the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine.

[0020] 1.2 Drugs and reagents: houttuyfonate sodium (batch number: 070103), product of Shanghai Qingping Pharmaceutical Co., Ltd.; isoproterenol hydrochloride injection (batch number: 5E20010), product of Shanghai Hefeng Pharmaceutical Co., Ltd.; metoprolol tartrate Er tablets (batch number: 0605002), product of AstraZeneca Pharmaceutical Co., Ltd.

[0021] 1.3 Preparation of Houttuyfonate Sodium Test Solution: Weigh an appropriate amount of Houttuyfonate Sodium, dissolve it in warm water and ultrasonically before use, and prepare a solution with a concentration of 4.5 and 9 mg / ml.

[0022] 1.4 Experimental method: ...

Embodiment 2

[0039] Example 2: Anti-L-Thyroxine Sodium-induced Ventricular Hypertrophy Experiment in Rats

[0040] 2.1 Experimental animals: SD rats, male, weighing 150-170 g, purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences, and raised in the SPF animal laboratory of the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine.

[0041] 2.2 Drugs and reagents: houttuyfonate sodium (batch number: 070103), product of Shanghai Qingping Pharmaceutical Co., Ltd.; L-thyroxine sodium (L-Thy, batch number: WA1331), product of Sigma Company; captopril (Captopril, Batch number: 061005), product of Shanghai Hengshan Pharmaceutical Co., Ltd.; endothelin (FT-1) kit (batch number: 070620), purchased from Beijing North Institute of Biotechnology; hydroxyproline kit (batch number: 20070623), tested Muscle blue protein assay kit (batch number: 20070515) was purchased from Nanjing Jiancheng Reagent Company.

[0042] 2.3 Preparation of Houtt...

Embodiment 3

[0060] Example 3: Anti-hypertrophic Effect of Houttuyfonate Sodium in Rats with Incomplete Ligation of Abdominal Aorta

[0061] 3.1 Experimental animals: SD rats, male, weighing 220-250 g, purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences, and raised in the SPF animal laboratory of the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine.

[0062] 3.2 Drugs and reagents: houttuyfonate sodium (batch number: 0711-3), product of Shanghai Qingping Pharmaceutical Co., Ltd.; Captopril (batch number: 070704), product of Shanghai Hengshan Pharmaceutical Co., Ltd.; angiotensin II kit (batch number: 20080420), aldosterone test kit (batch number: 20080420), tumor necrosis factor test kit (batch number: 20080530), were all purchased from Beijing North Institute of Biotechnology; Coomassie brilliant blue protein assay kit (batch number : 20070515), purchased from Nanjing Jiancheng Reagent Company.

[0063] 3.3 Preparatio...

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Abstract

The invention discloses new application of sodium houttuyfonate in pharmacy, in particular to the application of the sodium houttuyfonate in preparing medicaments for preventing and treating myocardial hypertrophy and / or ventricular hypertrophy. The application is to prepare an in-vitro myocardial cell hypertrophyby adopting three methods of preparing an in-vivo animal model of myocardial hypertrophy and ventricular hypertrophy, culturing a myocardial cell in vitro and inducing epinephrine by isoproterenol, L-thyroxine and abdominal aorta banding. Experiment results prove that the sodium houttuyfonate can reduce the increase of left cardiac index and global cardiac index of a model animal, inhibit hypertrophy of an in-vitro myocardial cell, reduce the cAMP concentration of plasma, the content of Ang II and ET-1 of a myocardial tissue and the content of TNF-alpha and ALD of serum, and can reduce blood pressure and decrease heart rate. Experiment results suggest that the sodium houttuyfonate has the functions of resisting myocardial hypertrophy and ventricular hypertrophy, and the mechanism of the sodium houttuyfonate can be related to the inhibition of sympathetic activity, blockage of system activity of feritin-hypertensin-aldosterone, and effect of endocrine factors.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to the use of houttuyfonate sodium, an active ingredient of traditional Chinese medicine, in the preparation of medicines for preventing and treating myocardial hypertrophy and / or ventricular hypertrophy. Background technique [0002] Chronic cardiac insufficiency, also known as congestive heart failure (CHF), is a clinical syndrome in which the pumping function of the heart is reduced due to various etiologies and cannot discharge enough blood to meet the metabolic needs of tissues and organs throughout the body. The fatality rate is high. [0003] In the past, the clinical treatment of CHF focused on the use of cardiac glycosides with positive inotropic effects and diuretics. A large number of clinical data show that although all drugs that enhance myocardial contractility and improve hemodynamics can achieve a certain effect of improving symptoms in the short term, they cannot prevent ventr...

Claims

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Application Information

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IPC IPC(8): A61K31/121A61P9/04
Inventor 高建平陈长勋
Owner SHANGHAI UNIV OF T C M
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