Unlock instant, AI-driven research and patent intelligence for your innovation.

Tablet-in-tablet compositions

A composition and tablet-in-tablet technology, which can be applied in drug combinations, active ingredients of heterocyclic compounds, diseases, etc., and can solve problems such as contraindications

Inactive Publication Date: 2010-01-20
WYETH LLC
View PDF6 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In some patients, therapy may be contraindicated due to proliferative effects of unopposed estrogens on uterine tissue

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tablet-in-tablet compositions
  • Tablet-in-tablet compositions
  • Tablet-in-tablet compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[1279] Preparation of Conjugated Estrogen Granules Comprising 27.5% HPMC K100M and Compression of the Granules into Tablet Form

[1280] One feature of the tablet forms described herein is a core tablet comprising, for example, a conjugated estrogen. Examples 1-3 are examples demonstrating the production of conjugated estrogen ("CE") particles. In this Example 1, for the production of CE granules, HPMC K100M Premium Controlled Release (CR) grade (Dow Chemical Co., Midland, MI) was chosen to be used based on its controlled release characteristics. HPMC Premium CR grades are specially produced ultra-micronized materials that ensure rapid hydration and gel formation.

[1281] Lactose-containing CE dry matter ("CEDL") (Wyeth, Madison, NJ) was used. 42.9 mg CE / g of CEDL of the mixture was granulated by the following method using a high shear granulator using the balance (spiked) of water of the remaining components in Table 1 as described below for the 1.5 kg batch size.

[1282...

Embodiment 2

[1296] Preparation of Conjugated Estrogen Granules Containing 20% ​​HPMC K100M and Compression of the Granules into Tablet Form

[1297] Using the component amounts in Table 2, a granulated CE blend was prepared and used to form tablets by following the method of Example 1.

[1298] Table 2

[1299] describe

[1300] Note: (A) means removed during processing.

Embodiment 3

[1302] Preparation of Conjugated Estrogen Granules Containing 10% HPMC K100M and Compression of the Granules into Tablet Form

[1303] Using the component amounts in Table 3, a granulated CE blend was prepared and used to form tablets by following the method of Example 1.

[1304] table 3

[1305] describe

[1306] Note: (A) means removed during processing.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The present invention is directed to tablet-in-tablet compositions comprising one or more estrogens in a first layer and a therapeutic agent in a second layer, and processes for their preparation..

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application Serial No. 60 / 884,801, filed January 12, 2007, which is incorporated herein by reference in its entirety. field of invention [0003] The present invention generally relates to the field of pharmaceutical formulations. More particularly, the present invention relates to tablet-in-tablet compositions and methods of making such compositions. In certain embodiments, the composition comprises one or more estrogens in a core tablet and one or more therapeutic agents in a compressed outer sheet. Background of the invention [0004] Menopause is generally defined as the last natural menstrual period and is characterized by cessation of ovarian function, resulting in a substantial decrease in circulating estrogen in the bloodstream. In retrospect, menopause is usually determined after 12 months of absence. It is usually not a sudden event, but usually occurs bef...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K45/06A61K31/55A61K31/57A61K31/565
CPCA61K9/2013A61K31/565A61K31/57A61K9/209A61K9/2054A61K9/2018A61K45/06A61K31/55A61P15/12A61P19/10A61P5/30A61K2300/00A61K9/20
Inventor X·刘J·克雷塞维克N·巴克什R·埃尼弗
Owner WYETH LLC