Supercharge Your Innovation With Domain-Expert AI Agents!

New application of asperosaponin VI

Dipsacus saponin, the only technology used in the field of drugs for the treatment of liver diseases, can solve the problems of high cost, easy recurrence, unsatisfactory treatment effect, etc.

Inactive Publication Date: 2012-05-09
SHANDONG LUYE PHARMA CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Interferon is the drug of choice, but there are disadvantages such as large dosage, high cost, high toxicity and side effects, low effective rate, and easy recurrence after drug withdrawal.
The curative effect of traditional Chinese medicine is also unsatisfactory, so there is an urgent need to provide new effective drugs for the treatment of hepatitis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New application of asperosaponin VI
  • New application of asperosaponin VI
  • New application of asperosaponin VI

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0016] Preparation Example 1: Preparation of Dipsacus saponin VI

[0017] Take 1 kg of Dipsacus chuanxiong medicinal material, crush it, pass through a 10-mesh sieve, add 10 times the amount (V / W) of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, and recover the ethanol from the extract until it has no alcohol smell. Add ethanol to the concentrated solution until the alcohol concentration is 80%, and let stand overnight; filter with suction, concentrate the filtrate to no alcohol smell, add 5 times the amount of water, let stand overnight, filter, and treat the AB-8 macroporous resin on the filtrate (resin The weight ratio of medicinal materials is 1:1), wash 2 column volumes with 0.5% sodium hydroxide solution, wash with water to neutrality, then elute with 40% ethanol for 3 column volumes, discard, and finally wash 3 column volumes with 50% ethanol Column volume, collect 50% ethanol eluent, concentrate and evaporate to dryness to obtain about ...

preparation example 2

[0018] Preparation Example 2: Preparation of Dipsacus saponin VI

[0019] Take 1 kg of Dipsacus chuanxiu medicinal material, crush it, pass through a 10-mesh sieve, add 8 times the amount (V / W) of 75% ethanol to soak overnight, reflux extraction three times, each time for 2 hours, recover the ethanol from the extract until it has no alcohol smell, filter , the processed D101 macroporous resin on the filtrate (resin and medical material weight ratio 1: 1), 1.0% sodium hydroxide solution washes 2 column volumes and washes with water to neutrality, then uses 35% ethanol to elute 3 column volumes , discarded, and finally washed 3 column volumes with 50% ethanol, collected 50% ethanol eluate, concentrated and evaporated to dryness to obtain about 60g of crude extract (the content of Dipsacus saponin VI is about 60%); The material was put on a silica gel column, and eluted with chloroform-methanol (2:1) as a solvent, and the eluate was collected, concentrated, and crystallized repea...

preparation example 3

[0020] Preparation Example 3: Preparation of Chuanxuan Saponin VI Injection:

[0021] prescription:

[0022] Dipsacus saponin VI 5.0g

[0023] Sodium chloride 89g

[0024] Water for injection 10000ml

[0025] Made into 10000ml

[0026] Preparation method:

[0027] Measure Dipsacus saponin VI 5.0g and sodium chloride 89g according to the prescription, dissolve them in 10,000ml of water for injection, stir, add 0.2% activated carbon, stir for 20 minutes, filter the solution through a microporous membrane to clarify, and pack in 125ml infusion bottles Medium, 100mL per bottle, sterilized and packed after passing the inspection. Other inspection items should meet the requirements for injection items in the Pharmacopoeia of the People's Republic of China 2005 Edition.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides new application of asperosaponin VI, and in particular relates to the application of the asperosaponin VI in medicaments for preventing or treating acute and chronic liver injuries and liver fibrosis.

Description

technical field [0001] The invention relates to a medicine for treating liver diseases, in particular to the application of Dipsacus saponin VI in the prevention or treatment of acute and chronic liver injury and liver fibrosis caused by viruses, chemical substances and medicines. Background technique [0002] Hepatitis means inflammation of the liver. Infection by many pathogenic microorganisms such as viruses, bacteria, fungi, rickettsia, spirochetes, and some protozoa and parasites may cause liver inflammation; poisoning by various poisons, toxins, chemicals, and certain drugs can cause poisoning hepatitis. The hepatitis caused by drug poisoning is called drug-induced hepatitis; the hepatitis caused by chemical substances is called chemical hepatitis; the hepatitis caused by viruses is called viral hepatitis. [0003] Currently, western medicines for the treatment of hepatitis include interferon, interferon inducer, nucleoside derivatives and so on. Interferon is the d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P1/16
Inventor 侯建李敏徐本明朱海波
Owner SHANDONG LUYE PHARMA CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com