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Chinese medicinal preparation for treating osteoporosis

A traditional Chinese medicine preparation and osteoporosis technology, which is applied in the direction of medical preparations containing active ingredients, bone diseases, drug combinations, etc., can solve the problems of difficult patient acceptance, many types of drugs, and high prices, and achieve low toxicity and side effects. Clear, low-cost effects

Inactive Publication Date: 2011-08-31
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calcitonin has a certain effect on osteoporosis, but it is expensive and difficult to be accepted by the majority of patients
Chinese patent CN97107552.2 discloses a medicine for preventing and treating osteoporosis, which is prepared according to the conventional preparation method from Epimedium, Dipsacus chuanxiong, Psoraleae, Rehmannia, Salvia miltiorrhiza and Anemarrhena anemarrhena according to the theory of traditional Chinese medicine. It has obvious curative effect on osteoporosis and various orthopedic diseases, but there are many types of drugs and complex formulas

Method used

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  • Chinese medicinal preparation for treating osteoporosis
  • Chinese medicinal preparation for treating osteoporosis
  • Chinese medicinal preparation for treating osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 only gets the epimedium extract and makes tablet of the present invention

[0045] The preparation method of the epimedium extract: take 10 kilograms of dried epimedium raw materials and pulverize them into coarse powder, extract by percolation with 75% ethanol, and the amount of ethanol is 8 times of the weight of the raw materials to be 80 kilograms (generally 4 to 12 times) . Concentrate the leachate until it has no alcohol smell, go to D 101 The macroporous resin is first washed with water, then eluted with 70% ethanol, eluted with ethanol and concentrated to dryness, recrystallized repeatedly with 70% ethanol, dried and crushed to obtain the epimedium extract containing icariin . The content of icariin in the extract is detected by high performance liquid chromatography to be 80%, and the tablet of the present invention is made.

Embodiment 2

[0046] Embodiment 2 Get Fructus Cnidii, Dipsacus extract and mix in any proportion and make the pill of the present invention

[0047] Get 10 kilograms of Fructus Cnidii and Dipsacus respectively, diafiltration with ethanol, and repeated crystallization, respectively make Fructus Cnidii extract, extract of Dipsacus, detect wherein osthole, Dipsacus saponin VI through high performance liquid chromatography The contents of the two extracts are both greater than 10%, and the two extracts are mixed in any proportion to make a pill.

Embodiment 3

[0048] Example 3 The extracts of Epimedium, Cnidium Fructus, and Dipsacus are mixed in a molar ratio of 1:1:1 to make capsules

[0049] Adopt the conventional preparation method of embodiment 1,2 to extract, respectively make three kinds of extracts of the present invention, mix (being that epimedium, Cnidiac Fructus Fructus Cnidii, Dipsacus extracts are 1:1:1 by molar ratio) 67.6g, 24.4g, and 92.9g respectively), add 2% starch of the total weight as a filler, and use 50% ethanol in an appropriate amount as a wetting agent to make a soft material. Dry at ℃ for 6 hours, sieve and granulate, and pack into capsules.

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PUM

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Abstract

The invention provides a Chinese medicinal preparation for treating osteoporosis, which is prepared from a Herba Epimedii extract with icariin content being higher than 10% and / or a Cnidium monnieri fruit extract with osthole content being higher than 10% and / or a Dipsacus asperoides extract with asperosaponin VI content being higher than 10% by mixing at an optional proportion. The Chinese medicinal preparation has hormone-like action; and has the effects of regulating in vivo calcium and phosphorus metabolism, tonifying liver and kidney, reuniting bones, regulating blood circulation, and improving symptoms of osteoporosis, such as pain in waist and back and weakness of feet and knees. The Chinese medicinal preparation can be used for treating senile osteoporosis with high effectiveness,good therapeutic effect and low toxic and adverse effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine preparation for treating osteoporosis. Background technique [0002] Osteoporosis is a systemic disease characterized by damage to the microstructure of bone tissue, loss of bone mineral composition and bone matrix, bone thinning, decreased number of trabecular bone, increased bone fragility, and increased risk of fracture. Diseases of bone metabolism disorders. Osteoporosis is generally divided into two categories, namely primary osteoporosis and secondary osteoporosis. Degenerative osteoporosis can be divided into postmenopausal osteoporosis and senile osteoporosis. The prevalence rate of the elderly is 60.72% for men and 90.47% for women. The most common form of senile osteoporosis is that with age, hormone levels in the body decrease and bone resorption increases. Most of the onset is relatively slow, some of them are relatively ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/296A61P19/10
Inventor 罗维早覃瑶阳勇王海军翁代群李钰婷王婷婷
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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