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Chitosan-collagen-diprospan slow releasing system, preparation method and application thereof

A technology of chitosan and collagen, which is applied in the field of biotechnology and polymer medical materials, can solve the problems of large side effects and difficult control of local application concentration, and achieve the effects of reducing scars, preventing adhesion between scars and nerves, and promoting the growth of endothelial cells

Inactive Publication Date: 2010-03-10
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term application of the whole body has many side effects, and the concentration of local application is not easy to control.
[0007] Although a variety of biofilms with different degradation rates and mechanical properties and local slow-release drugs continue to come out, and there have been some attempts to promote nerve regeneration, so far, there are no reports at home and abroad about the physical barrier and pharmacological effects. Drug sustained-release system that works simultaneously without side effects and promotes nerve regeneration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take 3% acid-soluble chitosan and 1.5% collagen, mix them at a ratio of 1:9, then gradually add 0.2ml of Diprosone suspension, mix thoroughly for 60 minutes, then gradually drop in 36 % formaldehyde 2ml, poured into the mold after 5 minutes, demolded after standing for 1 hour, washed with distilled water and then dried in a freezer vacuum dryer for 12 hours to obtain a chitosan-collagen-Diprolone slow-release film, at 4 °C deposit. The thickness of the film is 0.5 mm, and the dried film has a tubular structure with one side open.

Embodiment 2

[0041] Take 3% acid-soluble chitosan and 1.5% collagen, mix them in a ratio of 1:9, then gradually add 0.4ml of Diprosone suspension, mix thoroughly for 60 minutes, then gradually drop in 36 % formaldehyde 2ml, poured into the mold after 5 minutes, demolded after standing for 1 hour, washed with distilled water and then dried in a freezer vacuum dryer for 12 hours to obtain a chitosan-collagen-Diprolone slow-release film, at 4 °C deposit. The thickness of the film is 0.5 mm, and the dried film has a tubular structure with one side open.

Embodiment 3

[0043] Take 3% acid-soluble chitosan and 1.5% collagen, mix them at a ratio of 1:9, then gradually add 0.6ml of Diprosone suspension, mix thoroughly for 60 minutes, then gradually drop in 36 % formaldehyde 2ml, poured into the mold after 5 minutes, demolded after standing for 1 hour, washed with distilled water and then dried in a freezer vacuum dryer for 12 hours to obtain a chitosan-collagen-Diprolone slow-release film, at 4 °C deposit. The thickness of the film is 0.5 mm, and the dried film has a tubular structure with one side open.

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Abstract

The invention relates to a chitosan-collagen-diprospan slow releasing system, which belongs to the field of biotechnology and medical materials. The chitosan-collagen-diprospan slow releasing system is prepared from chitosan and collagen serving as medicine carriers and steroid hormone (diprospan) serving as a slow releasing medicine. The chitosan-collagen-diprospan releasing system has good biocompatibility and absorbability, and can play a role in physically blocking and inhibiting the growth of fibroblasts; and the diprospan releases at a constant speed through medicine slow releasing technology so that the diprospan can inhibit the proliferation of capillaries and fibroblasts for long term and prevent the formation of adhesion and scars. The chitosan-collagen-diprospan slow releasing system can be used for repairing peripheral nerves clinically, and can provide meaningful reference for the discussion of promoting nerve regeneration and improving nerve function recovery.

Description

technical field [0001] The invention belongs to the field of biotechnology and polymer medical materials, and specifically relates to a chitosan-collagen-depot slow release system, a preparation method thereof and an application in peripheral nerve repair. Background technique [0002] Peripheral nerve injury is a common trauma in clinical practice. Due to its high incidence and poor treatment effect, it has always been a difficult problem in the field of trauma surgery. Clinical practice has shown that an important reason that hinders the further improvement of the repair effect after peripheral nerve injury is the local scar hyperplasia at the suture site of the nerve. Hematoma occurs locally after nerve repair, and fibroblasts from different parts migrate and invade the hematoma. Under the chemotactic stimulation of inflammatory mediators and growth factors released by inflammatory cells, fibroblasts gather, proliferate, synthesize, and secrete into the wound. Collagen f...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K9/70A61K31/573A61P25/02
Inventor 徐建光陆九洲蒋军健
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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