Nano-emulsion of vitamin E oil and preparation method thereof

A technology of nanoemulsion and vitamins, which is applied in the direction of antidote, pharmaceutical formula, emulsion delivery, etc., can solve the problems of inability to adjust the behavior (distribution and elimination) of drugs in the body, and achieve physical stability, improve therapeutic effect, and good curative effect Effect

Inactive Publication Date: 2010-05-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Classic drug dosage forms (e.g. tablets, ointments, injections) do not modify the behavi

Method used

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  • Nano-emulsion of vitamin E oil and preparation method thereof
  • Nano-emulsion of vitamin E oil and preparation method thereof
  • Nano-emulsion of vitamin E oil and preparation method thereof

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Experimental program
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preparation example Construction

[0030] The preparation method of vitamin E nanoemulsion of the present invention comprises the steps:

[0031] a. Vitamin E colostrum preparation steps: Stir an appropriate amount of emulsifier and co-emulsifier evenly, then add an appropriate amount of vitamin E oil under high-speed stirring, continue to stir to form milky white colostrum, then add an appropriate amount of solvent, stir to completely dissolve.

[0032] b. Add pH adjuster and various additives as needed, adjust the pH of the colostrum to about 7.0, and replenish it to the full amount with a solvent to obtain a nano-emulsion that is slightly milky white to nearly transparent with opalescence.

[0033] c. Filtration step: filter the nanoemulsion obtained in step b through a 0.22 μm filter membrane to remove impurities with larger particle sizes.

[0034] Of course, the preparation method of the present invention can also use any existing equipment and process for preparing nanoemulsions.

Embodiment 1

[0038] 1) Accurately weigh 6.75g of Tween-80 and 2.25g of glycerin, and stir the emulsifier and co-emulsifier evenly on a constant temperature stirrer;

[0039] 2) Add 1g of vitamin E oil under high-speed stirring, continue to stir to form milky white colostrum, then add an appropriate amount of pure water, stir to completely dissolve;

[0040] 3) adjust the pH to 7.0 with 0.1mol / L sodium hydroxide solution;

[0041] 4) Replenish to 100mL with pure water, and adjust the volumetric flask to volume. Obtain nano-emulsions from slightly milky white to near transparent with opalescent;

[0042] 5) The nanoemulsion is filtered through a 0.22 μm filter membrane, and the filtrate is poured into a suitable brown bottle, sealed with a press cap, and the product is obtained.

Embodiment 2

[0044] 1) Accurately weigh 5.6g of Tween-80 and 1.4g of glycerin, and stir the emulsifier and co-emulsifier evenly on a constant temperature stirrer;

[0045] 2) Add 1g of vitamin E oil under high-speed stirring, continue to stir to form milky white colostrum, then add an appropriate amount of pure water, stir to completely dissolve;

[0046] 3) adjust the pH to 7.0 with 0.1mol / L sodium hydroxide solution;

[0047] 4) Replenish to 100mL with pure water, and adjust the volumetric flask to volume. Obtain nano-emulsions from slightly milky white to near transparent with opalescent;

[0048] 5) The nanoemulsion is filtered through a 0.22 μm filter membrane, and the filtrate is poured into a suitable brown bottle, sealed with a press cap, and the product is obtained.

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Abstract

The invention discloses a nano-emulsion of vitamin E oil and a preparation method thereof, wherein the nano-emulsion of vitamin E oil comprises vitamin E, an emulsifier, an emulsification assistant and a solvent. The average particle size of emulsion particles of the vitamin E nano-emulsion is approximately 20 nm, thus effectively solving the problems of physical stability of preparation and chemical stability of vitamin E oil, reducing the toxic and side effect and adverse reaction thereof, and improving the treatment effect of medicine.

Description

technical field [0001] The invention relates to a strong antioxidant, in particular to a vitamin E oil nanoemulsion preparation and a preparation method. Background technique [0002] Vitamin E is a fat-soluble, powerful antioxidant that is synthesized only by photosynthetic organisms. It is generally extracted from the deodorized distillate during the refining process of vegetable oil (soybean, rapeseed, cottonseed, rice bran, corn, sunflower seed, safflower seed, etc.). As early as the 1960s and 1970s, researchers used radioisotope labeling techniques to study the biosynthesis of α-tocopherol. By the 1980s, the biosynthesis pathway of α-tocopherol in higher plants and its synthesis in chloroplasts had been basically clarified. location. Photosynthetic organisms synthesize α-tocopherol through a series of enzymatic reactions. The main dosage forms of vitamin E preparations currently on the market are four dosage forms: tablets, soft capsules, powders, and injections. ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/355A61P39/06
Inventor 金一张萍王成润胡建鸿
Owner ZHEJIANG UNIV
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