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Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof

A technology of antioxidant activity and compounds, applied in the direction of organic active ingredients, chemical instruments and methods, organic chemistry, etc., can solve the problems of no report on the basis of active substances, no report on system research, etc., achieve simple extraction and separation process, and scavenge free radicals Effect

Inactive Publication Date: 2012-03-21
TIANJIN TIANSHI BIOLOGICAL DEV
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Problems solved by technology

[0004] Cotton ginseng has long been recorded in the famous Tibetan medicine "Jingzhu Materia Medica". At present, only Chengdu Institute of Biology, Chinese Academy of Sciences has divided 28-epi-cyasterone, Eriophytonoide, Cyasterone, ajuforrestinsA and B, 20- hydroxyecdysone, polypodinB, ajugalactone, 8-O-acetylharpagid, apigenin, -sitosterol daucosterol, and N-[2-hydroxy-(nonadecanoyl-tricosanoyl)]-4-hydroxytrans-8-sphingenine and other compounds, while its fat-soluble part and Systematic research on water-soluble parts has not been reported, and at the same time, research on the basis of its active substances has not been reported at home and abroad

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  • Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof
  • Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof
  • Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof

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Embodiment Construction

[0017] The following drawings and preferred embodiments describe in detail the specific implementation and features provided according to the present invention as follows:

[0018] The chemical structural formula of the compound with antioxidant activity obtained by the present invention is:

[0019]

[0020] The compound is a colorless crystal, by ESI-MS m / z: 759[M+Na] + , 781[M+HCOO - ] - , it can be seen that its molecular weight is 736, combined with 1 H-NMR (D 2 O) and 13 C-NMR (D 2 O) data, determine that its molecular formula is C 32 h 48 o 19 , the degree of unsaturation is 9;

[0021] δ94.4, δ96.4, δ98.8 are three acetal carbon signals, HMQC shows δ C 141.4 / H δ5.79 and δ C 104.4 / δ H 4.73 is the carbon-hydrogen signal of the double bond. Combined with the HMQC and HMBC spectra, the NMR signal of the aglycone shows that there are two cyclopentane-type iridoid skeletons, one of which is the same as ajugoside, and the other is the same as Xiao A new skel...

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Abstract

The invention relates to a compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and an extracting method thereof. The compound is identified as new iridoid through modern spectral analysis, wherein the molecular weight is 736, and the molecular formula is C32H48O19. The extracting method comprises the following steps of: pulverizing whole eriophyton wallichii; extracting with ethanol; sequentially extracting by using petroleum ether, ethylacetate and water saturated n-butanol; carrying out chromatography on the n-butanol part by macroporous absorption resin; and carrying out column chromatography on 30 percent of an elution part sequentially through MCI-GEL CHP20P, ODS-A and Sephadex LH-20 so as to obtain wallchiiside D. The new iridoid has simple preparation method, low cost and obvious activity and provides a new compound for developing medicaments having antioxidant effects.

Description

technical field [0001] The invention relates to a method for extracting new compounds from Tibetan medicinal ginseng, in particular to a compound with antioxidant activity extracted from Tibetan medicinal cotton ginseng and an extraction method thereof. Background technique [0002] Tibetan medicine is a unique medical care method formed by the Tibetan people in our country during the long-term struggle with the natural environment, and it is a treasure of traditional medicine of the motherland. Tibet is a plateau environment with high cold, hypoxia, strong radiation, and no pollution. Therefore, Tibetan medicine has the characteristics of long growth cycle, unique curative effect, and high accumulation of active substances. Although there are Tibetan medicine health care products on the market, the variety is relatively single, and the efficacy factors and their structure-effect-dose-effect relationship are not clear, which is not conducive to the development of the third-g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04C07H1/08A61K31/7048A61P39/06A23L1/29A23L33/00
Inventor 范秋领赵明明
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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