Method of derivatising an analyte for subsequent detection through a nucleic acid based sensor

An analyte and sensor technology, applied in the field of derivative analytes, can solve the problem that the system cannot be easily implanted into small devices

Inactive Publication Date: 2010-06-09
SONY CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This requires complex lighting, optics and detection systems that cannot be easily incorporated into small devices

Method used

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  • Method of derivatising an analyte for subsequent detection through a nucleic acid based sensor
  • Method of derivatising an analyte for subsequent detection through a nucleic acid based sensor
  • Method of derivatising an analyte for subsequent detection through a nucleic acid based sensor

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Embodiment

[0064] a) Analytes / small molecules according to the invention are molecules with low molecular weight (preferably in the range of 1-500 Da, more preferably in the range of 10-300 Da, most preferably in the range of 50-250 Da) and have the following classification First functional group:

[0065] Aliphatic or aromatic primary amines, secondary amines, monoamines, diamines, triamines

[0066] Aliphatic or aromatic monothiol, dithiol, trithiol

[0067] Aliphatic or aromatic monoalcohols, diols, triols

[0068] Aliphatic or aromatic monoketones, diketones, triketones

[0069] Aliphatic or aromatic monoaldehydes, dialdehydes, trialdehydes

[0070] Aliphatic or aromatic monocarboxylic acid, dicarboxylic acid, tricarboxylic acid

[0071] Aliphatic or aromatic monocarboxylates, dicarboxylates, tricarboxylates

[0072] Aliphatic or aromatic monoethers, diethers, triethers

[0073] Aliphatic or aromatic monoepoxides, diepoxides, triepoxides

[0074] Aliphatic or aromatic monohali...

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Abstract

Provided is a method of derivatising an analyte for subsequent detection through a nucleic acid based sensor. The present invention is directed to a method of derivatising an analyte for subsequent detection through a nucleic acid based sensor, and to a sensor based thereon.

Description

technical field [0001] The present invention relates to methods of derivatizing analytes for subsequent detection by nucleic acid-based sensors, and to sensors based on the above. Background technique [0002] Since the in vitro evolution principle (Systematic Evolution of Ligands by Exponential Enrichment, SELEX) was proposed in the late 1980s, a large number of synthetically derived nucleic acids mimicking high specificity and high affinity for a large variety of target molecules have been established molecular. Recently, such molecules (ie, functional nucleic acids, FNAs hereinafter) have attracted much attention in several fields such as environmental monitoring analysis, diagnosis, drug discovery and anti-disease therapy. [0003] Generally speaking, a sensor is mainly composed of two main units: a signal receiver unit and a signal conduction unit. The chemical receiver unit contains synthetically derived materials that interact with the sample or analyte. The lower ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12Q1/44G01N27/00
CPCC12Q1/6825G01N33/5308
Inventor J·厄尔默M·休尔科I·霍斯帕克G·内尔斯
Owner SONY CORP
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