Preparation method of implanted magnetic control drug microchip

An implantable, microchip technology, applied in the direction of drug devices, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the loss of the advantages of silicon electromechanical devices, the non-degradable silicon electromechanical devices, and the inability to permanently reside, etc. question

Inactive Publication Date: 2010-06-30
CHONGQING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. Silicon electromechanical devices are non-degradable and cannot permanently reside in the human body; silicon electromechanical devices must be removed after treatment
[0006] 2. The design and control of silicon electromechanical devices are based on microelectronic technology. Through electrochemical and electrothermal characteristics, etc., the release of drugs can only be realized at one time, and repeated operations of opening and closing cannot be performed.
[0008] However, the polylactic acid microchip designed entirely based on polymer compounds loses the advantages of silicon electromechanical devices, and the release behavior of the chip can only be controlled according to the natural degradation characteristics of polymer compounds.

Method used

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  • Preparation method of implanted magnetic control drug microchip
  • Preparation method of implanted magnetic control drug microchip

Examples

Experimental program
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Embodiment

[0024] ①Use the MGK7350 CNC high-precision horizontal axis circular table surface grinder to process and grind ultra-fine grain ultra-high carbon steel (carbon content is 1%), and then use Mitsubishi slow-moving wire cutting machine (instrument accuracy is ±0.02um) to grind the high-carbon steel Protrusions are processed on the surface, and the protrusions are uniformly distributed in a 9×9 array, and the shape of each protrusion is a cube structure of 500um×500um×500um;

[0025] ②Purchase general commercial analytical pure tin plate, cut out 1.5cm×1.5cm×5mm cube tin block with Taiwan fast and precise heavy-duty vertical milling machine (VS type), smooth the surface of tin block; The template is imprinted on the tin template to obtain a tin template with a groove structure, the grooves are distributed in a 9×9 array, and each groove is a cube structure of 500um×500um×500;

[0026] ③ Polish and polish the obtained tin stencil with grooves to make the surface error of the tin st...

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Abstract

The invention discloses a preparation method of an implanted magnetic control drug microchip, which has the steps of: firstly, preparing a polylactic acid drug chip with a drug storage pool by a polydimethylsiloxane convex plate, adding drugs into the drug storage pool and covering ferroferric oxide nanometer particles with high purity on the drugs, and finally, sealing the drug storage pool by a nuclear pore polycarbonate membrane. The preparation method has the advantages of simple operation, easy implementation and low cost. After the obtained polylactic acid chip with drugs is implanted in a human body, the active control of the release action of the drugs can be really realized by the magnetic property of ferroferric oxide and the release of the drugs in fixed point, time and ration of the added drugs through pulse. The invention has wide application prospect in organizational project and the field of the slow release of drugs.

Description

technical field [0001] The invention relates to a medicine chip, in particular to a preparation method of an implantable magnetically controlled medicine microchip. Background technique [0002] In drug therapy, excessive drug is likely to cause too many side effects, and a small amount of drug delivery will reduce the therapeutic effect. Therefore, how to optimize the drug treatment is a major problem in clinical medicine. Although oral medicine is still the treatment that patients and doctors are most willing to accept at present, the instantaneous drug concentration in the body of oral medicine is too high, and the drug concentration is too low afterwards, which reduces the medical effect; at the same time, many macromolecular drugs have poor water solubility, The degradation rate is fast and the side effects are large, so many researchers and clinicians are trying to explore other drug delivery methods (Nature Biotechnology 2003; 21: 1184-1191). The ideal drug release i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00A61K47/34
Inventor 蔡开勇罗忠
Owner CHONGQING UNIV
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