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37 results about "Nuclear pore" patented technology

A nuclear pore is a part of a large complex of proteins, known as a nuclear pore complex that spans the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are approximately 1,000 nuclear pore complexes (NPCs) in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in the life cycle. The human nuclear pore complex (hNPC) is a 110 MDa structure. The proteins that make up the nuclear pore complex are known as nucleoporins; each NPC contains at least 456 individual protein molecules and is composed of 34 distinct nucleoporin proteins.About half of the nucleoporins typically contain solenoid protein domains—either an alpha solenoid or a beta-propeller fold, or in some cases both as separate structural domains. The other half show structural characteristics typical of "natively unfolded" or intrinsically disordered proteins, i.e. they are highly flexible proteins that lack ordered tertiary structure. These disordered proteins are the FG nucleoporins, so called because their amino-acid sequence contains many phenylalanine—glycine repeats.

Colorectal cancer Septin9 gene methylation detection kit based on graded anchoring probe

The invention discloses a colorectal cancer Septin9 gene methylation detection kit based on a graded anchoring probe, and belongs to the technical field of molecular diagnosis. The graded anchoring probe is composed of a specific capture probe (F1), a precise anchoring probe (R1), a synergistic blocking probe (F2 / R2) and a short chain complementary sequence (S1) which are Septin9 methylation specific probes and can be fixed in a conical pore channel of a nuclear track membrane in a graded manner to form a capture-anchoring-blocking functional chain; during application, a general accumulation body is formed by combining with a Septin9 methylation target, a nuclear track membrane pore channel is blocked, current drop is caused, and detection is realized. Through cooperation of the probe, the nuclear track membrane and the electrochemistry, the problems of insufficient sensitivity, poor stability and poor specificity of traditional detection are solved, and the kit is suitable for ultra-early diagnosis of colorectal cancer.
Owner:UNION BIOTECH TIANJIN

Air freight nuclear track membrane humidity regulation and control fresh-keeping system and method

The invention discloses an air freight nuclear track membrane humidity regulation and control fresh-keeping system and method, and the system comprises a cargo hold / container module which is an airplane main cargo hold or a container meeting the aviation standard, and is used for accommodating cargoes to be kept fresh and forming a closed microenvironment; the nuclear track membrane regulation and control layer is arranged in a mode of covering the ventilation opening of the cargo hold / container module, being integrated in the side wall structure or forming an independent humidity regulation buffer cabin; the nuclear track membrane regulation and control layer is composed of at least one layer of nuclear track membrane, and the nuclear track membrane is of a micropore structure which is uniform in pore diameter height and is of a straight-through pore channel. By introducing the intelligent molecular sieve, namely the nuclear track membrane, the system realizes dynamic bidirectional accurate regulation and control on the humidity in the aviation confined space. Compared with a traditional passive moisture absorption or complete sealing scheme, the system has the advantages that excessive moisture causing corruption can be actively removed, meanwhile, water molecules can be captured from a relatively dry airborne environment for humidification, and the two problems of moisture condensation and excessive drying are fundamentally solved.
Owner:刁玉锋

Preparation method of nuclear pore membrane with nuclear micropores arranged in order based on AAO as transmission membrane

PendingCN122323582AEtchingPolymer substrate
The application discloses a method for directly preparing a nuclear micropore membrane with regularly arranged nuclear micropores based on a large-area AAO transmission film, and belongs to the technical field of nuclear micropore membrane preparation. The method comprises the following steps: taking a large-area through-hole anodic aluminum oxide (AAO) film as an ion transmission template, closely adhering the AAO film to a polymer substrate, and performing one-time vertical high-energy particle irradiation; particles penetrate along the regular channels of the AAO and form a large-area regular irradiation damage array on the substrate, which corresponds to the template; and through sensitization, chemical etching and post-processing, a nuclear micropore membrane with consistent nuclear micropore distances and regular arrangement is directly obtained. The method omits the traditional multiplication, alignment and multiple irradiation steps, is simple in process, high in product yield, and capable of large-area mass production, and is high in regularity of the nuclear micropore array, adjustable in parameters, and significantly improves the application performance of the nuclear micropore membrane in high-end fields such as radiation detection, wave absorption and high-precision separation.
Owner:田泽宇

A fluorine removing agent and a method for preparing the same

The application discloses a fluorine removal agent and a preparation method thereof, and relates to the technical field of fluorine removal agents, and comprises the following components in parts by weight: 5-10 parts of an aluminum salt, 5-10 parts of an iron salt, 15-20 parts of a rare earth material, sodium citrate and beta-cyclodextrin; the addition amount of the sodium citrate is 5%-10% of the total mass of the aluminum salt, the iron salt and the rare earth material; and the addition amount of the beta-cyclodextrin is 30%-50% of the mass of the sodium citrate. Through the introduction of the synergistic system of sodium citrate and beta-cyclodextrin, the metal ion precipitation sequence is regulated, meanwhile, the beta-cyclodextrin captures competitive anions through molecular recognition and constructs a hydrogen bond network to block interference, and the combination of the microsphere type and the porous particle type further realizes dynamic directional transmission of pollutants and nuclear pore limited crystallization, and the active site distribution is reconstructed at the molecular level, so that a technical scheme with universality, economy and reliability is provided for the treatment of complex fluorine-containing wastewater.
Owner:ZHAOQING LINGYU ENVIRONMENTAL PROTECTION IND CO LTD

Irradiation and feeding system for nuclear track membrane

PendingCN120987082AWebs handlingMechanical engineeringNuclear pore
The invention discloses a nuclear track membrane irradiation and feeding system. The system comprises an irradiation mechanism; the unwinding assembly is arranged on one side of the irradiation mechanism; the winding assembly is arranged on the other side of the irradiation mechanism, and the unwinding assembly and the winding assembly are symmetrically arranged up and down relative to the irradiation mechanism; the first automatic feeding and discharging module is arranged on the side, away from the irradiation mechanism, of the unwinding assembly, and the first automatic feeding and discharging module is configured to place a raw material film roll on the unwinding assembly and take down a tailing film roll from the unwinding assembly; the second automatic feeding and discharging module is arranged on the side, away from the irradiation mechanism, of the winding assembly, and the second automatic feeding and discharging module is configured to take down the finished film roll from the winding assembly and place the empty roll core on the winding assembly. Through the arrangement of the first automatic feeding and discharging module and the second automatic feeding and discharging module, feeding can be conducted on the unwinding assembly, discharging can be conducted on the winding assembly, feeding is more convenient and faster, feeding and discharging are more accurate, the working efficiency is improved, and the working intensity is reduced.
Owner:INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI

A method for irradiation preparation of a nuclear pore membrane with uniform pore distribution

The application belongs to the field of membrane material preparation, and relates to a method for preparing a nuclear pore membrane with uniform pore distribution through irradiation, comprising the following steps: determining the vertical size of a beam spot according to the size of a beam window; setting a nuclear pore membrane original film, ensuring that the nuclear pore membrane original film is stretched and taut; performing one-dimensional scanning on the nuclear pore membrane original film by using an ion beam with the determined vertical size; during the one-dimensional scanning, determining the irradiation fluence of an irradiation single scanning period according to the transmission rate v and the transverse scanning frequency f . I 0 The application couples the transmission rate v and the transverse scanning frequency f as main control parameters, achieves the accuracy of the irradiation fluence I , ensures the irradiation uniformity, avoids the transverse stripes generated by irradiation while achieving the target irradiation fluence, and realizes the uniform pore distribution in the process of preparing the nuclear pore membrane through irradiation.
Owner:INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI

Recyclable nuclear pore structure MOF nanoflame retardant and preparation method thereof

The present application relates to a kind of recyclable nuclear pore structure MOF nano flame retardant and its preparation method, belong to the cross technical field of nano and flame retardant.The present application provides a kind of nuclear pore structure MOF nano flame retardant, polyurethane foam is soaked in high concentration nano flame retardant, and foam material no longer appears melt drop phenomenon and self-extinguishes from fire, cannot be secondarily ignited, and foam material shows good flame-retardant heat-insulating effect, and smoke suppression effect is outstanding.After being introduced into foam material, the elasticity of foam material itself is improved, in addition, the nuclear pore structure of it gives foam material itself higher sound insulation and noise reduction effect.
Owner:BEIJING INST OF TECH

Preservation box containing nuclear track membrane

The utility model provides a preservation box containing a nuclear track membrane. The preservation box comprises a box body, a cover body used for opening or closing the box body and a preservation mechanism used for controlled atmosphere preservation. The fresh-keeping mechanism comprises an inner window body, an outer window body detachably connected to the inner window body and an air adjusting assembly arranged between the inner window body and the outer window body, the inner window body is used for preventing liquid in the box body from entering the air adjusting assembly, and the outer window body is used for preventing liquid outside the box body from entering the air adjusting assembly; the air adjusting assembly is clamped and fixed through the inner window body and the outer window body. The air adjusting assembly comprises a front dust cover, a rear dust cover detachably connected to the front dust cover and a nuclear track membrane located between the front dust cover and the rear dust cover, and the nuclear track membrane is clamped and fixed through the front dust cover and the rear dust cover. The air conditioning device has the advantages of being stable in air conditioning function, convenient to maintain and suitable for household use.
Owner:GUANGDONG KEQING ENVIRONMENTAL TECH CO LTD

Nucleopore membrane modified atmosphere packaging system

The application discloses a nuclear pore membrane modified atmosphere packaging device production system, which comprises a mother piece feeding mechanism, a nuclear pore membrane cutting mechanism, a sub piece feeding mechanism and a multiple-speed chain conveying line. The automatic feeding of the mother piece and the sub piece is realized through the mother piece feeding device and the sub piece feeding device, and the automatic cutting of the nuclear pore membrane during the assembling process of the nuclear pore membrane and the sub piece is realized through the nuclear pore membrane cutting device. The overall assembling of the nuclear pore membrane modified atmosphere packaging device is realized to be automatic, the working efficiency of the assembling is obviously improved, and the qualified rate of the finished product is improved.
Owner:SHANDONG ZANGRUN ENVIRONMENTAL PROTECTION TECH CO LTD

A biological sample analysis method and system based on nuclear pore distribution patterns

ActiveCN120726038BImage enhancementImage analysisMicroscopic imageNuclear membrane
The present application relates to the field of tumor detection, and in particular to a biological sample analysis method and system based on nuclear pore distribution patterns. The method provided by the present application comprises: S101, obtaining microscopic image data of a biological sample; S102, obtaining a first region of interest, a second region of interest and a third region of interest; S103, drawing a nuclear membrane edge curve; S104, extracting nuclear pore distribution-nuclear membrane curvature distribution data of cells in the biological sample; S105, identifying the nuclear pore distribution pattern of the cells in the biological sample; S106, evaluating the state of the tissue or organ corresponding to the biological sample. Based on the identified nuclear pore distribution pattern of individual cells in the biological sample, the present application can evaluate the state of the tissue or organ corresponding to the biological sample according to the overall nuclear pore distribution pattern of the cells in the biological sample, such as whether it is a tumor sample, whether it has a tendency to cancer, etc., which is of great significance for early diagnosis of tumors.
Owner:SHANGHAI JIAOTONG UNIV

Fluorine removal agent and preparation method thereof

The invention discloses a fluorine removal agent and a preparation method thereof, and relates to the technical field of fluorine removal agents, the fluorine removal agent comprises the following components by weight: 5-10 parts of an aluminum salt, 5-10 parts of an iron salt, 15-20 parts of a rare earth material, sodium citrate and beta-cyclodextrin; the adding amount of the sodium citrate is 5%-10% of the total mass of the aluminum salt, the ferric salt and the rare earth material; the addition amount of the beta-cyclodextrin is 30%-50% of the mass of the sodium citrate; a synergistic system of sodium citrate and beta-cyclodextrin is introduced, the precipitation sequence of metal ions is regulated and controlled, meanwhile, beta-cyclodextrin captures competitive anions through molecular recognition and constructs a hydrogen bond network to block interference, and dynamic directional transmission and nuclear pore confinement crystallization of pollutants are further achieved through combination of a microsphere type and a porous particle type. Active site distribution is reconstructed on the molecular level, and a technical scheme with universality, economical efficiency and reliability is provided for complex fluorine-containing wastewater treatment.
Owner:ZHAOQING LINGYU ENVIRONMENTAL PROTECTION IND CO LTD

Rapid non-destructive testing method of nanopore membrane based on dark-field scattering optical method

The application provides a kind of nanometer hole nuclear pore membrane rapid nondestructive testing method based on dark field scattering optical method, comprising: using dark field optical microscope to focus on the nuclear pore membrane to be detected, after focusing, adjust to dark field mode, obtain the scattering light image of the nuclear pore membrane to be detected under dark field mode;Determine the image area and the number of scattering light spots in the image based on the scattering light image, obtain the density of the nuclear pore membrane;Move the dark field optical microscope light spot center to the single hole position to collect dark field scattering spectrum, obtain the single hole dark field scattering spectrum intensity I ;Based on the relationship between scattering spectrum intensity I And aperture D Formula I = aD 2 +b , the aperture of the nuclear pore module is calculated by the single hole dark field scattering spectrum intensity I Therefore, the application has the advantages of simple operation, low cost, fast detection speed, etc., and can be widely applied in the field of nanotechnology and material science.
Owner:INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI

High-fidelity expansion microscopic imaging method for nuclear pore compound

The invention relates to a high-fidelity expansion microscopic imaging method of a nuclear pore complex, which is characterized in that the signal intensity and the dyeing coverage are obviously enhanced through the immunostaining conditions of 37 DEG C temperature and prolonged incubation time, and the permeability of an antibody in iterative expansion gel is improved; by adopting a secondary anchoring cross-linking condition that 2.8% paraformaldehyde and 10% acrylamide are proportioned, under the condition that the expansion rate is not reduced, the structural heterogeneity index is further reduced, and the marking integrity is improved; through treatment of 92.5 mM SDS under the denaturation condition of 85 DEG C for 1.5 h, full denaturation can be achieved, and deformation and signal loss caused by protein breakage can be reduced. During imaging, the signal-to-noise ratio of fluorescence after single expansion is improved by using a water immersion objective lens, so that a clear annular NPC structure can be obtained by using a confocal microscope; therefore, the image fidelity and the signal-to-noise ratio are remarkably improved, and a technical basis is provided for subsequently realizing near-molecule-scale NPC imaging under a confocal microscope.
Owner:XIAMEN UNIV

Self-pressure-relief waterproof loudspeaker with waterproof and breathable nuclear track vibrating membrane

The invention discloses a self-pressure-relief waterproof loudspeaker with a waterproof and breathable nuclear track vibrating membrane, and belongs to the technical field of loudspeakers. Comprising a loudspeaker support, a nuclear track waterproof breathable vibrating membrane and a loudspeaker surface cover, the nuclear track waterproof breathable vibrating membrane is composed of a nuclear track membrane, one end of the loudspeaker support is provided with a loudspeaker magnetic circuit, loudspeaker coils are arranged inside and outside the loudspeaker magnetic circuit, and the loudspeaker coils are fixedly connected with the nuclear track waterproof breathable vibrating membrane. The loudspeaker surface cover presses the edge of the nuclear track waterproof breathable vibrating membrane on the loudspeaker support. Compared with a first-generation self-pressure-relief waterproof loudspeaker, the self-pressure-relief waterproof loudspeaker is simple in production process. The nuclear pore waterproof and breathable vibrating membrane achieves waterproof and breathable functions, is high in mechanical strength and good in toughness, and meets the requirements of deep waterproof products for toughness and high-pressure tearing of the waterproof and breathable membrane. The nuclear track membrane is good in air flow consistency, can meet the requirements of an electronic product with a built-in air pressure sensor and an electronic product for accurately measuring the current altitude, and has deep waterproof and air leakage functions.
Owner:DONGGUAN HEYU ELECTRONIC TECH CO LTD

Preparation method for nuclear pore membrane having regularly arranged nuclear micropores

A preparation method for a nuclear pore membrane having regularly arranged nuclear micropores, a radiation detector probe manufactured using the nuclear pore membrane, and a wave-absorbing material prepared using the nuclear pore membrane. Multiple single-pore nuclear pore membranes are used to prepare a dual-pore nuclear pore membrane having pores at a certain spacing, multiple dual-pore nuclear pore membranes are used to prepare a four-pore nuclear pore membrane having pores at a certain spacing and regularly arranged, and so on, a nuclear pore membrane having orderly arranged nuclear micropores is prepared using the principles of multiplication. An insulating material layer is sandwiched between two conductive material layers of a nuclear pore membrane or two sides of an insulating membrane are coated with conductive layers, and then orderly arranged nuclear micropores are formed, so as to obtain a radiation detector probe. Nuclear pore membranes having different pore sizes and taper angles are stacked and staggered to broaden the wavelength range of electromagnetic waves absorbed by the wave-absorbing material.
Owner:TIAN ZEYU

Gradient nuclear track membrane based on heavy ion irradiation and application of gradient nuclear track membrane in cherry preservation

The invention discloses a gradient nuclear track membrane based on heavy ion irradiation and application of the gradient nuclear track membrane in cherry preservation, and belongs to the technical field of nuclear track membrane preparation. The method is used for solving the problems that in the prior art, PET films do not have pore diameters with moderate quantity and particle sizes, so that the PET films for storing cherries are too high in compactness and low in air permeability, and excessive anaerobic respiration exists during cherry storage. In addition, the technical problem that the PET film is poor in biological antibacterial activity is solved. The invention provides a gradient nuclear track membrane based on heavy ion irradiation for cherry preservation. The gradient nuclear track membrane based on heavy ion irradiation is composed of a nuclear track membrane substrate, and a first coating layer and a second coating layer which are sequentially coated on the surface of the nuclear track membrane substrate, the nuclear track membrane substrate is obtained by sequentially carrying out heavy ion irradiation, ultraviolet sensitization and alkaline etching liquid etching on a PET (Polyethylene Terephthalate) film; the first coating solution is obtained by dissolving copper zinc pyrithione and dopamine in ethanol, and the second coating solution is obtained by dissolving silver nitrate in ethanol.
Owner:YIJIA (HUBEI) NEW MATERIAL TECH CO LTD

Preparation method and application of an electrochemical biosensor based on MOF / nuclear pore membrane sandwich structure

The application relates to a preparation method and application of an electrochemical biosensor based on a MOF / nuclear pore membrane sandwich structure and belongs to the technical field of biosensing. The electrochemical biosensor based on the MOF / nuclear pore membrane sandwich structure comprises a nuclear pore membrane substrate, a MOF functional layer, a conductive enhancement layer and a biological recognition layer. The nuclear pore membrane substrate provides stable physical support for the MOF functional layer by taking the nuclear pore membrane as the substrate, simultaneously guides the directional transmission of target molecules along the pore channel and reduces diffusion resistance; the MOF functional layer is modified by in-situ growth of MOF materials on the inner wall of the nuclear pore membrane channel, the density of active sites is increased, then a continuous MOF layer is formed on the surface of the nuclear pore membrane, selective separation and sensing are realized and the current signal is amplified; the conductive enhancement layer is modified by a conductive material in the MOF channel to form a continuous conductive network, the electrode interface resistance is reduced, the transmission of electrons from the reaction site to the external circuit is accelerated, a conductive coating is prepared on the surface of the nuclear pore membrane as the electrode interface signal, the signal-to-noise ratio is reduced and the stability is improved; and the biological recognition layer is used for specific recognition of target molecules by fixing DNA probes on the surface of the MOF. The electrochemical biosensor based on the MOF / nuclear pore membrane sandwich structure can utilize the mechanical support and ordered pore channel of the nuclear pore membrane and improve the sensing performance through the functional surface of the MOF, and is suitable for high-sensitivity and high-selectivity biological molecule detection.
Owner:T J BIOTECH TIANJIN

Nuclepore membrane gas exchange window

1. The name of the design product: nuclear pore membrane air conditioning window. 2. The use of the design product: for packaging box in the wet, temperature control, gas exchange. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.
Owner:HUINONG WISDOM (SHANGHAI) FRESH PRESERVATION TECHNOLOGY CO LTD

Preparation method of enzyme membrane sensor for detecting glutamine

PendingCN121068728AMaterial analysis by electric/magnetic meansEnzyme membranePolycarbonate filter
The invention relates to a preparation method of an enzyme membrane sensor for detecting glutamine, and aims to provide a biosensor which can be matched with different redox electrodes for use, has general applicability and good performance and is suitable for online monitoring of glutamine. The enzyme membrane takes a polycarbonate filter membrane as a basement membrane, and is prepared by the following steps: fixing a nuclear track filter membrane on an O-shaped rubber ring, sequentially dropwise adding an enzyme solution on the filter membrane, and finally covering a layer of nuclear track filter membrane. The glutaminase membrane disclosed by the invention has relatively short response time and relatively stable operability, and meanwhile, the preparation process of the glutaminase membrane is simple and relatively low in cost.
Owner:WUXI TMAXTREE BIOTECHNOLOGY CO LTD

Preparation method of novel liposome for efficient bacterial detection and aggregation

The invention discloses a preparation method of a novel liposome for efficiently detecting and gathering bacteria, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: weighing phosphatidylcholine, dioleoyl phosphatidyldimethylalanine and cholesterol according to a molar ratio of POPC: DOTAP: Cholesterol of 3: 3: 4, dissolving in chloroform, carrying out rotary evaporation at 25 DEG C to form a lipid membrane, carrying out hydration, vortex and ultrasonic treatment by using PBS (Phosphate Buffer Solution) (pH 7.4), extruding by using a nuclear track membrane and a support membrane, and finally determining related parameters by using a dynamic light scattering technology. The lipidosome can be rapidly combined with bacteria, rapid detection and targeting of the bacteria are achieved, bacteria aggregation is promoted to reduce in-vivo diffusion, and the lipidosome is of great significance to early rapid detection and control of clinical bacteria.
Owner:PEOPLES HOSPITAL PEKING UNIV

Rapid nondestructive detection method for nanopore nuclear track membrane based on dark field scattering optical method

The invention provides a nanopore nuclear track membrane rapid nondestructive detection method based on a dark field scattering optical method, which comprises the following steps: focusing a nuclear track membrane to be detected by using a dark field optical microscope, adjusting to a dark field mode after focusing, and obtaining a scattered light image of the nuclear track membrane to be detected in the dark field mode; determining the image area and the number of scattered light spots in the image based on the scattered light image, and obtaining the density of the nuclear track membrane; moving the light spot center of the dark-field optical microscope to the position of a single hole for dark-field scattering spectrum acquisition to obtain single-hole dark-field scattering spectrum intensity I; and based on a relational expression I = aD2 + b between the scattering spectrum intensity I and the aperture D, calculating the aperture of the nuclear pore model through the single-pore dark field scattering spectrum intensity I. Therefore, the method has the advantages of simplicity and convenience in operation, low cost, high detection speed and the like, and can be widely applied to the fields of nanotechnology and material science.
Owner:INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI

Method for automatic measurement of pore size of a nuclear pore membrane

The application discloses a kind of nuclear pore membrane pore size automatic measurement method, by being plated to sample surface conductive film, to the sample after plating film is carried out electron microscope scanning, to scanning image sequentially do USM sharpening processing, corrosion inflation processing, hough circle detection processing, obtain nuclear pore membrane hole inside and outside diameter and its statistical distribution;The method of the application can detect all the pores of nuclear pore membrane, and the concentric circles, intersecting circles are detected by hough circle gradient detection algorithm and concentric circle processing algorithm, with high accuracy, the error is within 5% with artificial statistics;Using algorithm automatically operates, detection time is short, does not need manual operation, greatly improves detection accuracy;And simple architecture can be transplanted and run, improve application range.
Owner:CHINA INSTITUTE OF ATOMIC ENERGY

Nuclear track membrane online haze feedback production method

PendingCN121832453AFacilitate automatic feedback productionThe detection method is simpleProgramme total factory controlTransmittanceEngineering
The invention discloses an on-line haze feedback production method for a nuclear track membrane. The method comprises the following steps: controlling the advancing speed of a membrane material through a winding and unwinding device; etching the membrane material through an etching device to obtain a nuclear track membrane; cleaning the etching liquid on the nuclear track membrane through a cleaning device; drying the cleaned nuclear track membrane through a drying device; detecting the nuclear track membrane through haze detection equipment to obtain a real-time haze detection result and a real-time light transmittance detection result; and according to the real-time haze detection result and the real-time light transmittance detection result, operating parameters of the winding and unwinding device and the etching device are adjusted in real time. The method can achieve the real-time detection of the thickness and pores of the nuclear track membrane on a production line through haze and light transmittance detection, facilitates the automatic feedback production, is simple in detection method, and is high in detection speed. Equipment cost can be greatly saved, production efficiency is improved, and production waste is reduced.
Owner:SHAANXI KEJIN FILM TECH CO LTD

Replaceable and detachable nuclear track membrane structure and atomizer

The utility model discloses a replaceable and detachable nuclear track membrane structure and an atomizer, and relates to the technical field of atomizers, the replaceable and detachable nuclear track membrane structure comprises a liquid bin, a boss is arranged in the middle of the liquid bin, an atomization groove is formed in the middle of the boss, a liquid storage cavity is formed between the liquid bin and the boss, a metal loading plate, an atomization nuclear track membrane and a piezoelectric ceramic ring are arranged in the atomization groove, and micropores are distributed in the center of the atomization nuclear track membrane. The boss is provided with a water drawing mechanism, the piezoelectric ceramic ring is connected with a power source, the atomization groove is provided with a clamping assembly matched with the atomization nuclear track membrane, the clamping assembly comprises a lifting pressing plate which is arranged in the atomization groove and connected with the piezoelectric ceramic ring, and the boss is provided with a displacement mechanism for promoting the lifting pressing plate to move in the vertical direction. A locking mechanism is arranged between the lifting pressing plate and the atomization nuclear track membrane and comprises an arc-shaped protrusion arranged on the atomization nuclear track membrane, and an arc-shaped groove is formed in the corresponding position of the lifting pressing plate. The atomization nuclear track membrane can be replaced conveniently, maintenance of the atomization nuclear track membrane is facilitated, the maintenance cost is low, and daily batch use is facilitated.
Owner:SHAANXI KEJIN FILM TECH CO LTD

Biological sample analysis method and system based on nuclear pore distribution mode

ActiveCN120726038AImage enhancementImage analysisMicroscopic imageNuclear membrane
The invention relates to the field of tumor detection, in particular to a biological sample analysis method and system based on a nuclear pore distribution mode. The method provided by the invention comprises the following steps: S101, acquiring microscopic image data of a biological sample; s102, acquiring a first region of interest, a second region of interest and a third region of interest; s103, delimiting a nuclear membrane edge curve; s104, extracting nuclear pore distribution-nuclear membrane curvature distribution data of cells in the biological sample; s105, identifying a nuclear pore distribution mode of cells in the biological sample; and S106, evaluating the state of the tissue or organ corresponding to the biological sample. Based on the identified nuclear pore distribution mode of the single cell in the biological sample, the state of the tissue or organ corresponding to the biological sample can be evaluated according to the overall nuclear pore distribution mode of the cells in the biological sample, for example, whether the tissue or organ is a tumor sample or not and whether the tissue or organ has the tendency of canceration or not, and the method has important significance on early diagnosis of tumors.
Owner:SHANGHAI JIAOTONG UNIV

Composite nuclear track membrane as well as preparation process and application thereof

The invention discloses a composite nuclear track membrane as well as a preparation method and application thereof. The composite nuclear track membrane comprises a supporting base layer and a two-layer structure membrane formed on the supporting base layer through membrane scraping and finishing, wherein the thickness of the supporting base layer ranges from 50 micrometers to 120 micrometers, the thickness of the two-layer structure membrane ranges from 10 micrometers to 50 micrometers, and the two-layer structure membrane comprises a compact layer and a loose layer; the thickness of the compact layer is 100-200 nm, the aperture of the compact layer is 0-40 nm, the thickness of the loose layer is 10-50 [mu] m, and the aperture of the loose layer is 0.1-10 [mu] m; the composite nuclear track membrane is applied to the biological component separator. The composite nuclear track membrane as well as the preparation method and the application thereof aim at solving the problems of a dialysis membrane used by a biological component separator in the prior art so as to meet the requirement for accurate separation of biological substances in medical and biological experiments, and have important practical significance.
Owner:JIANGSU VISION MEDICAL TECH CO LTD

A DNA tetrahedral probe for detecting lung cancer gene methylation and its application

PendingCN122303434ASingle strandA-DNA
This invention relates to the field of molecular detection technology, specifically to a DNA tetrahedral probe for detecting lung cancer gene methylation. The probe is formed by the self-assembly of four single-stranded DNA strands S1-S4, with S1 extending into a recognition arm targeting the methylated fragment of the PTGER4 promoter region. This invention immobilizes the tetrahedral probe on the inner wall of a nuclear pore membrane, preparing it as the core electrochemical detection component of a reagent kit. Utilizing the specific recognition capabilities of the nuclear pore membrane and the probe, combined with electrochemical detection technology, rapid detection of PTGER4 gene methylation is achieved without the need for PCR nucleic acid amplification. This detection system is simple to operate, low in cost, and can be widely applied to screening high-risk groups for lung cancer.
Owner:UNION CHEMILUMINESCENCE DIAGNOSTICS (TIANJIN) LTD

Manufacturing method of fresh-keeping cabinet composed of phase-change material and nuclear track membrane

The invention discloses a manufacturing method of a fresh-keeping cabinet composed of a phase-change material and a nuclear track membrane, and the manufacturing method comprises the following steps: S1, preparing a plastic box body with a containing cavity which is used for placing articles to be preserved; s2, an interlayer is arranged in the wall body of the plastic box body or an independent phase change material unit is arranged in the containing cavity, and the containing cavity is filled with a paraffin phase change material; s3, according to the size of the plastic box body, one or more ventilation holes of 5-10 cm are formed in the side wall or the top of the plastic box body; and S4, a layer of nuclear track membrane is attached to each vent hole, and the nuclear track membrane has the preset hole diameter and hole density so as to regulate and control the micro-atmosphere environment. By utilizing the latent heat characteristic of the paraffin phase-change material, the temperature in the fresh-keeping cabinet can be kept relatively stable within a certain period of time without an external power supply, energy consumption is remarkably reduced, and the fresh-keeping cabinet belongs to an environment-friendly technology and is particularly suitable for being used in regions with unstable electric power, outdoor operation, short-distance transportation or occasions without power supplies.
Owner:刁玉锋

Nuclear track membrane fresh-keeping piece and fresh-keeping bag

The utility model provides a nuclear track membrane fresh-keeping piece and a fresh-keeping bag, the fresh-keeping piece comprises a sub-piece and a mother piece which are in threaded fit with each other, a nuclear track membrane is arranged between the sub-piece and the mother piece, the sub-piece and the mother piece are clamped on the wall of a container through threaded connection and clamp and fix the nuclear track membrane, and the sub-piece and the mother piece enable the nuclear track membrane to be communicated with the inside and the outside of the container. The utility model has the advantages of simple installation and high stability, and is suitable for different containers.
Owner:GUANGDONG KEQING ENVIRONMENTAL TECH CO LTD

Fresh-keeping packaging material based on heavy ion nuclear track membrane and three-dimensional graphene

The invention relates to the technical field of food fresh-keeping packaging materials, and particularly discloses a fresh-keeping packaging material based on a heavy ion nuclear track membrane and three-dimensional graphene. The fresh-keeping packaging material comprises a degradable PET matrix layer, a gradient nuclear track film layer and a three-dimensional graphene-nano-copper composite antibacterial layer, and the preparation method of the fresh-keeping packaging material comprises the following steps: soaking the degradable PET matrix layer, the gradient nuclear track film layer and the three-dimensional graphene-nano-copper composite antibacterial layer in a silane coupling agent solution; then placing the degradable PET matrix layer at the bottom of a hot pressing mold, covering the degradable PET matrix layer with the gradient nuclear track film layer, covering the gradient nuclear track film layer with the three-dimensional graphene-nano-copper composite antibacterial layer, performing hot pressing, and performing laser micropore treatment to obtain the graphene-nano-copper composite antibacterial film. The prepared fresh-keeping packaging material can meet the triple requirements of precise controlled atmosphere, long-acting antibiosis, environmental protection and degradability, and has a wide application prospect.
Owner:YIJIA (HUBEI) NEW MATERIAL TECH CO LTD