1results about How to "Implement fixed point" patented technology

This invention belongs to the field of biomedical polymer materials, and relates to pH / GSH spatiotemporal cascade-responsive antitumor nanomedicines, their preparation methods, and applications. The pH / GSH spatiotemporal cascade-responsive antitumor nanomedicines are formed by the self-assembly of polymer prodrugs with the structure shown in formula (1). The pH / GSH spatiotemporal cascade-responsive antitumor nanomedicines provided by this invention can highly sensitively identify and respond to the extremely narrow pH change window of the tumor microacid environment, achieving charge reversal on the nanomedicine surface and thus enhancing the cellular uptake efficiency of the nanomedicine. Subsequently, in response to the highly expressed GSH within the cells, it precisely releases the drug at specific points, killing tumor cells. Based on the dual significant characteristics of the acidic pH and GSH in the tumor microenvironment, this invention significantly improves the cellular uptake efficiency of the drug through a spatiotemporal cascade response mechanism of "pH-triggered charge reversal - GSH-induced controlled drug release," while simultaneously achieving precise and controllable drug release, effectively inhibiting cancer cell growth. This provides a general-purpose nanomedicine platform for solid tumor treatment that is structurally controllable, has excellent synergy, and possesses both basic research value and clinical translational potential. Formula (1)