A kind of pH response type tannic acid/chitosan nanocapsule and preparation method thereof

A technology of chitosan nano and tannic acid, applied in the field of medicine, can solve the problems of limiting the application of microcapsule wall materials, high cost, cumbersome synthesis steps, etc., achieve good economic development potential, low manufacturing cost, and simple preparation technology Effect

Active Publication Date: 2021-07-20
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the polymer materials for preparing microcapsule wall materials are usually artificially synthesized polymers. The synthesis steps of these polymers are cumbersome and the cost is high. More importantly, these organic polymers are mostly biotoxic, which severely limits their use as microcapsules Application of wall materials

Method used

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  • A kind of pH response type tannic acid/chitosan nanocapsule and preparation method thereof
  • A kind of pH response type tannic acid/chitosan nanocapsule and preparation method thereof
  • A kind of pH response type tannic acid/chitosan nanocapsule and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Weigh 0.15g of cetyltrimethylammonium bromide, dissolve it in 40mL of deionized water, stir in a water bath at 50°C for 15min, and obtain cetyltrimethylammonium bromide with a concentration of 3.75mg / mL Ammonium Micellar Solution.

[0031] (2) Weigh 50 mg of tannic acid and dissolve it in 50 mL of aqueous solution (containing 50 μL of acetic acid in the aqueous solution) to obtain an aqueous solution of acetic acid containing tannic acid at a concentration of 1 mg / mL; Aqueous solution of sugar in acetic acid. Measure 5 mL of acetic acid aqueous solution containing tannic acid and add it to 5 mL of cetyltrimethylammonium bromide micellar solution, and stir for 20 min, so that the surface of the micelles is coated with tannic acid; The acetic acid aqueous solution of the polysaccharide was added to the above solution, and stirred for 20 minutes, so that the surface of the tannic acid was covered with chitosan again, and the tannic acid / chitosan nanocapsules with a co...

Embodiment 2

[0033] (1) Weigh 0.15g of cetyltrimethylammonium bromide, dissolve it in 40mL of deionized water, stir in a water bath at 50°C for 15min, and obtain cetyltrimethylammonium bromide with a concentration of 3.75mg / mL Ammonium Micellar Solution.

[0034] (2) Weigh 150 mg of tannic acid and dissolve it in 50 mL of aqueous solution (containing 150 μL of acetic acid in the aqueous solution) to obtain an aqueous solution of acetic acid containing tannic acid at a concentration of 3 mg / mL; Aqueous solution of sugar in acetic acid. Measure 5 mL of acetic acid aqueous solution containing tannic acid and add it to 5 mL of cetyltrimethylammonium bromide micellar solution, and stir for 20 min, so that the surface of the micelles is coated with tannic acid; The acetic acid aqueous solution of the polysaccharide was added to the above solution, and stirred for 20 minutes, so that the surface of the tannic acid was covered with chitosan again, and the tannic acid / chitosan nanocapsules with a ...

Embodiment 3

[0036] Taking triclosan as an example, prepare drug-embedded tannic acid / chitosan nanocapsules:

[0037] (1) Weigh 0.15g of cetyltrimethylammonium bromide, dissolve it in 40mL of deionized water, stir in a water bath at 50°C for 15min, and obtain cetyltrimethylammonium bromide with a concentration of 3.75mg / mL Ammonium Micellar Solution.

[0038] (2) Weigh 4g of triclosan, dissolve it in 50mL of dichloromethane, and prepare a 20mg / mL mother solution, take 200μL of the mother solution and add it to 40mL of cetyltrimethylammonium bromide micellar solution, and ultrasonicate for 60min. Stir overnight to volatilize the dichloromethane to obtain a triclosan-embedded hexadecyltrimethylammonium bromide micellar solution.

[0039] (3) Weigh 50 mg of tannic acid and dissolve it in 50 mL of aqueous solution (containing 50 μL of acetic acid in the aqueous solution) to obtain an aqueous solution of acetic acid containing tannic acid at a concentration of 1 mg / mL; Aqueous solution of sug...

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Abstract

The invention discloses a preparation method of pH-responsive tannic acid / chitosan nanocapsules, which is characterized in that: cetyltrimethylammonium bromide, tannic acid and chitosan are used as raw materials, The target product is synthesized by layer-by-layer self-assembly method, namely tannic acid / chitosan nanocapsules with core-shell structure; wherein, the mass ratio of tannic acid, chitosan and cetyltrimethylammonium bromide is 0.27-0.8:0.27-0.8:1. The nanocapsule prepared by the invention can respond to pH changes, control release of embedded molecules, and improve utilization efficiency of drug molecules. The preparation method is simple and the cost is low, and has broad application prospects in the fields of food, medicine, biotechnology and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pH-responsive tannic acid / chitosan nanocapsule and a preparation method thereof. Background technique [0002] Microcapsule technology is a microcapsule technology that uses polymer materials to embed solid, liquid or even gas components to form a semi-permeable or sealed capsule. The capsule plays the role of isolating and protecting the embedded components, so as to reduce the impact of the external environment on them, improve their stability, and prolong the storage time. Secondly, the capsule has a slow-release function, which can control the release of embedded components and realize the precise release of functional components in a specific system. Therefore, microcapsules embedding functional components have attracted widespread attention in the fields of food, medicine, and biotechnology. [0003] In recent years, the drug release system constructed by stimuli-res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K9/52A61K47/36A61K47/12A61K47/18
CPCA61K9/5123A61K9/5161
Inventor 蔡昊原王鹏张盾
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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