Combination for protecting peroxide injury of myocardium

Abstract

The invention provides a combination for protecting peroxide injury of myocardium. The combination comprises the following raw materials (parts by weight of each raw material are shown in brackets): coenzyme Q100 (5 to 50), L-carnitine (10 to 500), and octocosanol (10 to 100). The combination can lessen lipid peroxidation of a myocardium cell membrane and improve the activity of antioxidant enzymes such as SOD, GSH-Px and CAT, thereby protecting the peroxide injury of the myocardium and delaying or eliminating sports fatigue.

Description

technical field

[0001] The present invention relates to a composition, in particular to a composition for protecting myocardial peroxidative damage and a preparation method thereof. Background technique

[0002] Since Dillard first proposed the role of free radicals in sports fatigue and injury in 1978, the relationship between free radicals and sports fatigue has received increasing attention. It not only enriches the theory of sports fatigue, but also opens up a new way and method for preventing and eliminating sports fatigue.

[0003] Many subsequent studies have found that strenuous or exhaustive exercise can increase the production of free radicals in the body, increase the production of lipid peroxidation product MDA, and reduce the activity of antioxidant enzyme systems. Further research has confirmed that antioxidant therapy can improve the endurance of exercise body, scavenge free radicals, reduce lipid peroxidation, and increase the activity of antioxidant enzymes...

Examples

Embodiment 1

[0045] The preparation of the preparation composition capsule of the present invention:

[0046] The raw materials coenzyme Q10, stearyl alcohol and L-carnitine were selected and sieved respectively, and the materials under the 40-mesh sieve were selected as the raw materials for preparing the preparation combination.

[0047] Weigh the following raw materials respectively: 105 g of coenzyme Q, 500 g of L-carnitine, 100 g of stearyl alcohol, 17 g of starch, and 3 g of micropowder silica gel, and then mix the components of the materials that are close to each other by weight in equal volumes from small to large, and stir well. , pour it into the capsule filling mold, fill the capsule, polish, and pack it.

Embodiment 2

[0049] Preparation of the preparation composition granules of the present invention:

[0050] The raw materials coenzyme Q10, stearyl alcohol and L-carnitine are selected and sieved respectively, and the materials under the 60-mesh sieve are selected as the raw materials for preparing the preparation combination.

[0051] Weigh the following raw materials: coenzyme Q10 50g, L-carnitine 100g, stearyl alcohol 10g, sucrose powder 400g, dextrin 100g, and then mix the materials with the same volume from small to large and fully Stir well.

[0052] Use 50% ethanol as a binder to make soft materials. The above soft materials are made into granules through a YK-160 swing granulator with a 14-mesh screen, and the granules are placed in a DPL-30 multifunctional boiling dryer. , 50 ℃ of boiling and drying for about 40 minutes, control the moisture of the particles at 5%, and then granulate, sub-pack, that is, too.

Embodiment 3

[0054] Preparation of the preparation composition tablet of the present invention:

[0055] The raw materials coenzyme Q10, stearyl alcohol and L-carnitine are selected and sieved respectively, and the materials under the 60-mesh sieve are selected as the raw materials for preparing the preparation combination.

[0056] Weigh the following raw materials respectively: coenzyme Q10 20g, L-carnitine 150g, stearyl alcohol 100g, lactose 200g, microcrystalline cellulose 100g, carboxymethyl starch sodium 20g, and then the components that are close to the material by weight are composed of Mix the same volume from small to large, stir well, use 3% hydroxypropyl methylcellulose aqueous solution as a binder to make soft materials, and pass the above soft materials through a YK-160 swing granulator with an 18-mesh screen. To form granules, put the granules into the DPL-30 multifunctional boiling dryer, boil and dry at 50 ° C for about 40 minutes, control the moisture of the granules to b...

technical field

[0001] The present invention relates to a composition, in particular to a composition for protecting myocardial peroxidative damage and a preparation method thereof. Background technique

[0002] Since Dillard first proposed the role of free radicals in sports fatigue and injury in 1978, the relationship between free radicals and sports fatigue has received increasing attention. It not only enriches the theory of sports fatigue, but also opens up a new way and method for preventing and eliminating sports fatigue.

[0003] Many subsequent studies have found that strenuous or exhaustive exercise can increase the production of free radicals in the body, increase the production of lipid peroxidation product MDA, and reduce the activity of antioxidant enzyme systems. Further research has confirmed that antioxidant therapy can improve the endurance of exercise body, scavenge free radicals, reduce lipid peroxidation, and increase the activity of antioxidant enzymes...

Examples

Embodiment 1

[0045] The preparation of the preparation composition capsule of the present invention:

[0046] The raw materials coenzyme Q10, stearyl alcohol and L-carnitine were selected and sieved respectively, and the materials under the 40-mesh sieve were selected as the raw materials for preparing the preparation combination.

[0047] Weigh the following raw materials respectively: 105 g of coenzyme Q, 500 g of L-carnitine, 100 g of stearyl alcohol, 17 g of starch, and 3 g of micropowder silica gel, and then mix the components of the materials that are close to each other by weight in equal volumes from small to large, and stir well. , pour it into the capsule filling mold, fill the capsule, polish, and pack it.

Embodiment 2

[0049] Preparation of the preparation composition granules of the present invention:

[0050] The raw materials coenzyme Q10, stearyl alcohol and L-carnitine are selected and sieved respectively, and the materials under the 60-mesh sieve are selected as the raw materials for preparing the preparation combination.

[0051] Weigh the following raw materials: coenzyme Q10 50g, L-carnitine 100g, stearyl alcohol 10g, sucrose powder 400g, dextrin 100g, and then mix the materials with the same volume from small to large and fully Stir well.

[0052] Use 50% ethanol as a binder to make soft materials. The above soft materials are made into granules through a YK-160 swing granulator with a 14-mesh screen, and the granules are placed in a DPL-30 multifunctional boiling dryer. , 50 ℃ of boiling and drying for about 40 minutes, control the moisture of the particles at 5%, and then granulate, sub-pack, that is, too.

Embodiment 3

[0054] Preparation of the preparation composition tablet of the present invention:

[0055] The raw materials coenzyme Q10, stearyl alcohol and L-carnitine are selected and sieved respectively, and the materials under the 60-mesh sieve are selected as the raw materials for preparing the preparation combination.

[0056] Weigh the following raw materials respectively: coenzyme Q10 20g, L-carnitine 150g, stearyl alcohol 100g, lactose 200g, microcrystalline cellulose 100g, carboxymethyl starch sodium 20g, and then the components that are close to the material by weight are composed of Mix the same volume from small to large, stir well, use 3% hydroxypropyl methylcellulose aqueous solution as a binder to make soft materials, and pass the above soft materials through a YK-160 swing granulator with an 18-mesh screen. To form granules, put the granules into the DPL-30 multifunctional boiling dryer, boil and dry at 50 ° C for about 40 minutes, control the moisture of the granules to b...

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