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Preparation of petracenin from the root of pseudocihosh
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A kind of technology of rock cabbage element and pseudocimicha root, which is applied in the research and development field of affiliated pharmaceutical products
Inactive Publication Date: 2011-11-30
SHANDONG UNIV AT WEIHAI
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Problems solved by technology
[0004] At present, there are few reports at home and abroad on the research on the phytochemical components of False Cohosh
Method used
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Embodiment 1
[0015] Step (1): Take 2.3 kg of dried roots of False Cihosh and pulverize them, soak them in 50% ethanol for 10 hours, and then ultrasonicate for 1 hour at a temperature of 30° C. and a power of 80 W. Repeat 3 times, and then filter with gauze to obtain a filtrate;
[0016] Step (2): Combine the filtrates in step (1), concentrate, suspend the concentrate in water, extract with petroleum ether, ethyl acetate, and n-butanol in sequence, concentrate and recover the extraction solvent to obtain four parts;
[0017] Step (3): Dissolve 13.8 g of the ethyl acetate portion in step (2) with methanol, mix the sample with 16 g of silica gel, apply the sample to a 360 g, 100-200 mesh silica gel column, fill the column with chloroform, and elute with a chloroform-methanol gradient;
[0018] Step (4): The similar fractions in step (3) were combined and concentrated to obtain a concentrated solution, which was mixed with silica gel and applied to a silica gel column, packed with chloroform, a...
Embodiment 2
[0022] Step (1): take 2.5 kg of dried roots of False Cihosh and pulverize them, soak them in 50% ethanol for 12 hours, then ultrasonicate for 1.5 hours at a temperature of 30°C and a power of 80W, repeat 3 times, and then filter with gauze to obtain the filtrate;
[0023] Step (2): Combine the filtrates in step (1), concentrate, suspend the concentrate in water, extract with petroleum ether, ethyl acetate, and n-butanol in sequence, concentrate and recover the extraction solvent to obtain four parts;
[0024] Step (3): Dissolve 14 g of the ethyl acetate part in step (2) with methanol, mix the sample with 16 g of silica gel, and then apply a 360 g, 100-200 mesh silica gel column, pack the column with chloroform, and elute with a chloroform-methanol gradient;
[0025] Step (4): The similar fractions in step (3) were combined and concentrated to obtain a concentrated solution, which was mixed with silica gel and applied to a silica gel column, packed with chloroform, and eluted wi...
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Abstract
The invention belongs to the technical field of research and development of pharmaceutical products. The present invention relates to the preparation of petracenin in the root of false cohosh. Take the dried root of Pseudomonas cohosh and crush it, soak it in 50% ethanol for 10h-12h, then sonicate it for 1h-1.5h, the temperature is 30°C, the power is 80W, repeat 3 times, then filter with gauze, combine the filtrate, concentrate, suspend with water, Sequentially extract with petroleum ether, ethyl acetate and n-butanol, concentrate and recover the extraction solvent to obtain four parts, dissolve the ethyl acetate part with methanol, mix the sample with silica gel and put it on a silica gel column, pack the column with chloroform, chloroform-methanol gradient Elute, combine similar fractions, concentrate, further use silica gel column chromatography, combine similar fractions, concentrate, precipitate crystals, and recrystallize to obtain petrogin monomer. The main function of petracenin is to relieve cough and eliminate phlegm, and it also has anti-inflammatory, liver-protecting, anti-ulcer, and immune-enhancing effects. Further research and development of corresponding preparations can be used in clinical practice.
Description
technical field [0001] The invention belongs to the technical field of research and development of pharmaceutical products. The present invention relates to the preparation of petracenin in the root of false cohosh. The main function of the product of the invention is to relieve cough and eliminate phlegm, and also have the functions of anti-inflammation, liver protection, anti-ulcer, immunity improvement and the like. Further research and development of corresponding preparations can be used in clinical practice. Background technique [0002] The invention relates to the preparation of petracenin by taking the root of pseudo-cihoem as raw material. False cohosh Aruncus sylvester Kostel.ex Maxim. is the dried root of Aruncus sylvester (Aruncus) in the family Rosaceae. Alias: Ditang Huima, Medicinal function: Dispelling the wind and relieving the exterior, promoting blood circulation and relaxing tendons. Distribution area: Produced in Heilongjiang, Jilin, Liaoning, Henan...
Claims
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Application Information
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