Application of Angelica-Radix Hedysari ultrafiltration membrane extract in preparing medicine for radiation protection
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An ultrafiltration membrane and anti-radiation technology, which is applied in drug combinations, anti-toxins, and pharmaceutical formulations, can solve problems such as high toxicity and achieve the effect of improving bioavailability
Active Publication Date: 2013-03-20
GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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However, most of the currently known drugs with radiation protection effects are relatively toxic, so people start with natural drugs to expect the development of drugs that are less toxic and suitable for clinical prevention and treatment of radiation damage.
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Embodiment 1
[0022] The Chinese medicinal materials used in the present invention come from Minxian County, Gansu Province, the angelica is purchased from the production base of Minxian County, and the red qi is purchased from the medicinal material station of Minxian County.
[0023] Take angelica red qi decoction pieces and add water to decoct twice at a ratio of 1:5, add 6 times the mass of angelica hongqi decoction pieces for the first time and decoct for 2 hours, add 4 times the mass of angelica and red qi decoction pieces for 1 hour for decoction for the second time , put the two decoctions together overnight, filter the decoction to obtain the filtrate; the filtrate is then subjected to 100,000 molecular weight (molecular weight cut-off is 100,000) ultrafiltration membrane—polyethersulfone (PES) membrane ultrafiltration, and the ultrafiltration pressure is 0.3 Mpa, the temperature is 35°C, and the ultrafiltrate is spray-dried to make a dry powder.
Embodiment 2
[0025] In order to show the effect of the present invention on protection against radiation hazards, the present invention has carried out peripheral blood leukocyte count experiment, bone marrow cell DNA content determination experiment, mouse bone marrow cell micronucleus experiment, and superoxide dismutase (SOD) activity experiment in blood to animals , Serum hemolysin test.
[0026] 1. Experimental materials
[0027] 1.1 Animals
[0028] KM mice, SPF grade, male, weighing 20±2g, provided by the Experimental Animal Center of Gansu University of Traditional Chinese Medicine, quality certificate number: SCXK (Gan) 2004-0006, experimental facility use certificate number: SYXK (Gan) 2004-0006. The animals were reared in separate cages and fed solid feed provided by Beijing Keao Xieli Experimental Animal Feed Co., Ltd. with free access to water, room temperature 20-25°C, and relative humidity 45%-52%.
[0029] 1.2 Drugs and preparation
[0030] Radix Angelicae Radix Ultrafil...
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Abstract
The invention relates to an application method of an Angelica-Radix Hedysari ultrafiltration membrane extract in radiation protection. The method comprises the following steps of: taking tablets of Angelica and Radix Hedysari in the weight proportion of 1:5-6:6; adding 6 times of water to the Angelica tablets, and decocting for 2 hours; adding 4 times of water to the Radix Hedysari tablets, and decocting for 1 hour; mixing the decoction solutions, standing, and filtering to obtain a filtrate; ultrafiltering (20000-100000 molecular weight) the filtrate, and spray-drying the ultrafiltrate to obtain the dry powder. The invention carries out low-power X-ray one-shot total body radiation on a mouse by using a medical linear accelerator; the Angelica-Radix Hedysari ultrafiltration membrane extract water solution is respectively given to the mouse by gavage before and after the radiation; and the analysis on the variations of indices, such as peripheral blood leucocyte, spleen and thymus indices, DNA content in thighbone marrow cells, micronuclei number in marrow cells, superoxide dismutase (SOD) activity in blood, blood serum hemolysin and the like, indicates that the Angelica-Radix Hedysari ultrafiltration membrane extract has the function of radiation protection.
Description
technical field [0001] The invention relates to an ultrafiltration membrane extract of angelica and red qi and its application for anti-radiation. Background technique [0002] With the development of the national economy and the improvement of people's living standards, radiation is becoming more and more closely related to people's work and life. Due to the extensive development of clinical radiotherapy and chemotherapy for cancer patients, and the application of nuclear energy and nuclear technology in agricultural production, With a large number of applications in medical and health care, scientific research and national defense equipment, the radiation damage of occupationally exposed personnel has been paid more and more attention. There are more and more people exposed to radiation, and the damage is becoming more and more serious. However, most of the currently known drugs with radiation protection effects are relatively toxic, so people start with natural drugs to e...
Claims
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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P39/00
Inventor 李应东
Owner GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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