Raspberry leaf extract and application thereof in preparing anticoagulant and antithrombotic medicine

An antithrombotic drug and leaf extract technology, applied in the new medicinal uses of anticoagulation and antithrombosis, in the field of raspberry leaf water or alcoholic water extract, which can solve the problems of the coagulation system and the role of the thrombus model, which have not been reported. , to achieve significant medicinal effects, significant antithrombotic and anticoagulant activities, and no toxic side effects.

Inactive Publication Date: 2010-09-08
冯松元
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  • Description
  • Claims
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At present, domestic and foreign studies on its effect on the

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  • Raspberry leaf extract and application thereof in preparing anticoagulant and antithrombotic medicine
  • Raspberry leaf extract and application thereof in preparing anticoagulant and antithrombotic medicine

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preparation example Construction

[0020] 1. The preparation of raspberry leaf extract: take the leaf of red raspberry (also known as raspberry in Chinese pharmacy) as raw material, adopt solvent extraction method, resin adsorption method, and combine concentrated drying, freeze-drying Or spray drying and other common drying methods to obtain the water or alcoholic water extract of raspberry leaves. The alcohol is a saturated monohydric alcohol CnH having the general formula 2n+1 OH, n is 1, 2, 3 or 4, or unsaturated monoalcohol CnH 2n-1 OH, n is 2, 3 or 4.

[0021] The water or alcohol-water extract of red raspberry leaves is eluted with a water-alcohol mixed solvent through a macroporous adsorption resin to obtain different proportions of water-alcohol mixed solvent eluate. A macroporous adsorption resin column with a height ratio of 1:3-1:7, the eluate obtained by eluting with a mixed solvent containing water-alcohol in different proportions; the alcohol is a saturated monohydric alcohol CnH with the follo...

preparation example

[0023] Prepare the effective parts of red raspberry leaves by macroporous adsorption resin method: add 1300 grams of red raspberry leaves into 8000 ml of water, extract by heating and reflux, filter to remove the medicinal residues; add red raspberry leaf filter residues to 8000 ml of water and heat Reflux extraction, filter to remove medicinal residues; red raspberry leaves were heated and refluxed twice, each time for 2 hours, the two water extracts were combined, concentrated under reduced pressure at 50-90°C to 1200 ml to obtain red raspberry leaf water extract Concentrate. Get 800 milliliters of the above-mentioned red raspberry leaf water extraction concentrate, the extract is passed through the nonpolar macroporous adsorption resin HPD-100, and the column bed volume is 1700 milliliters, respectively with water, 30% ethanol, 70% ethanol and 95% Gradient elution with ethanol, the elution volume is 5100 ml respectively. The eluate was recovered solvent under reduced press...

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Abstract

The invention relates to biological medicine, in particular to a raspberry leaf extract and an application thereof in preparing an anticoagulant and antithrombotic medicine, the extract is raspberry leaf water extract, and the obtained raspberry leaf activity extraction part has anticoagulant and antithrombotic activity. The raspberry leaf extract and the application thereof have simple production process, convenient operation and low production cost.

Description

technical field [0001] The invention relates to biological medicine, in particular to a raspberry leaf water or alcohol water extract and the new medical application of the extract for anticoagulant and antithrombotic. Background technique [0002] A thrombus is a small piece of blood that forms on the surface of a vessel in the cardiovascular system where the lining has been peeled off or repaired. In variable flow dependent patterns, the thrombus consists of insoluble fibrin, deposited platelets, accumulated leukocytes, and trapped red blood cells. There are mutually antagonistic coagulation and anticoagulation systems in the blood (fiber protein dissolution system). The dynamic balance of the coagulation system and the fibrinolysis system not only ensures the potential coagulability of the blood but also ensures the fluid state of the blood at all times. However, sometimes under the action of certain factors that can promote the blood coagulation process, the above-ment...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P7/02A61K127/00
Inventor 冯松元
Owner 冯松元
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