Fructan consisting of 25 fructoses and 1 glucose

Abstract

The invention provides a fructan consisting of 25 beta-D-fructoses and 1 alpha-D-glucose, and a method for preparing the fructan from Hubei dwarf lilyturf tuber serving as a raw material. The fructan has obvious effect of reducing blood sugar of mice with type 2 diabetes, simultaneously improves the sugar tolerance of the mice with the type 2 diabetes, and obviously enhances the expression of insulin receptor (InsR), insulin receptor substrate (IRS-1), protein kinase and phosphatidylinositol3-kinase (PI3-K) to further accelerate the glucose to be converted into glycogen and improve the activities of glucose-6-phosphate and glucose-6-phophatase so as to obvious reduce the insulin resistance.

Description

Background technique

[0001] Diabetes mellitus (DM) is a chronic systemic frequently-occurring disease related to genetic factors and various environmental factors. It is a syndrome of sugar, fat and protein metabolism disorders caused by insufficient insulin secretion or utilization. Diabetes disease" category. The prevalence of diabetes in my country is increasing year by year, especially in type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM), but there is no ideal drug for treatment at home and abroad. Most of the chemical drugs currently used clinically to treat diabetes have serious adverse reactions. Long-term use needs to be increased and there is a possibility of secondary failure, especially the chronic complications cannot be effectively controlled. Traditional Chinese medicine has the characteristics of being easy to accept, less toxic and side effects, and suitable for long-term control of diabetes. It has irreplaceable advantages in effectively preven...

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