Fructan consisting of 25 fructoses and 1 glucose

A technology of fructan and glucose, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, and pharmaceutical formulas, and can solve problems such as dosage, adverse reactions, and secondary failures

Inactive Publication Date: 2010-09-22
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the chemical drugs currently used clinically to treat diabetes have serious adverse reactions, and long-term use needs to be increased and there is a possibility of secondary failure, especially the chronic complications cannot be effectively controlled

Method used

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  • Fructan consisting of 25 fructoses and 1 glucose
  • Fructan consisting of 25 fructoses and 1 glucose
  • Fructan consisting of 25 fructoses and 1 glucose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] The preparation of the invented fructan: take 5kg of Hubei Ophiopogon japonicus tuber, crush it into raw medicinal material powder, add water to decoct 3 times, add 20 liters of water for the first time, add 20 liters of water for the second time, add 10 liters of water for the third time, and boil each time For 30 minutes, combine the decoction; adjust the pH of the decoction to 6 with phosphate buffer, add 25g of papain with an activity of 12u / mg, enzymolyze in a water bath at 45°C for 2 hours, then boil immediately for 5 minutes at 4°C Stand still for more than 12 hours, suction filter to remove the precipitate; put the filtrate into a dialysis bag with a molecular weight of 1000, dialyze with tap water for 1 day, distilled water for another 1 day, concentrate the polysaccharide solution in the bag to 1.5g / mL, add absolute ethanol to ethanol Volume fraction is 80%, 4 DEG C stand still more than 12 hours, incline supernatant, collect precipitation; Precipitate is disso...

Embodiment 2

[0130] The preparation of the fructan capsule of the present invention: add 35 g of microcrystalline cellulose to 965 g of the fructan powder of the present invention, mix evenly, sieve, and dry to obtain the medicinal raw material of the drug capsule. The medicinal raw materials are filled into 2924 capsules, and each medicinal capsule containing 0.33g of the fructan of the present invention is prepared, which is equivalent to each capsule containing 2.68g of Hubei Ophiopogon japonicus medicinal material. Adults are advised to take the fructan capsules of the present invention once a day in the morning and evening, one capsule each time, for more than 4 weeks.

Embodiment 3

[0132] The preparation of the fructan tablet of the present invention: add 35 g of microcrystalline cellulose to 965 g of the fructan powder of the present invention, mix evenly, sieve, and dry to obtain the medicinal raw material of the drug tablet. The medicinal raw material is dry-processed into granules and compressed into tablets to obtain 5848 pharmaceutical tablets of the fructan of the present invention, each containing 0.165 g of the fructan of the present invention, which is equivalent to 1.34 g of the Hubei Ophiopogon japonicus medicinal material contained in each capsule.

[0133] It is recommended that adults take the fructan tablet of the present invention twice a day, once in the morning and before dinner, 2 tablets each time, and take continuously for more than 4 weeks.

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Abstract

The invention provides a fructan consisting of 25 beta-D-fructoses and 1 alpha-D-glucose, and a method for preparing the fructan from Hubei dwarf lilyturf tuber serving as a raw material. The fructan has obvious effect of reducing blood sugar of mice with type 2 diabetes, simultaneously improves the sugar tolerance of the mice with the type 2 diabetes, and obviously enhances the expression of insulin receptor (InsR), insulin receptor substrate (IRS-1), protein kinase and phosphatidylinositol3-kinase (PI3-K) to further accelerate the glucose to be converted into glycogen and improve the activities of glucose-6-phosphate and glucose-6-phophatase so as to obvious reduce the insulin resistance.

Description

Background technique [0001] Diabetes mellitus (DM) is a chronic systemic frequently-occurring disease related to genetic factors and various environmental factors. It is a syndrome of sugar, fat and protein metabolism disorders caused by insufficient insulin secretion or utilization. Diabetes disease" category. The prevalence of diabetes in my country is increasing year by year, especially in type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM), but there is no ideal drug for treatment at home and abroad. Most of the chemical drugs currently used clinically to treat diabetes have serious adverse reactions. Long-term use needs to be increased and there is a possibility of secondary failure, especially the chronic complications cannot be effectively controlled. Traditional Chinese medicine has the characteristics of being easy to accept, less toxic and side effects, and suitable for long-term control of diabetes. It has irreplaceable advantages in effectively preven...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/733A61P3/10
Inventor 陈家春陈祥洪白雪文莉方进波
Owner HUAZHONG UNIV OF SCI & TECH
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