External medicinal composition for treating skin ulcer and preparation method thereof

A technology for external use of drugs and skin ulcers, which is applied in the field of medicine and can solve problems such as clinical application limitations

Active Publication Date: 2011-11-09
JINAN SUNNYPHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In a word, the above treatment methods all have different degrees of defects, which greatly restrict the clinical application.

Method used

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  • External medicinal composition for treating skin ulcer and preparation method thereof
  • External medicinal composition for treating skin ulcer and preparation method thereof
  • External medicinal composition for treating skin ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] The preparation of embodiment 1 refined white sugar

[0162] 1. The proportion of raw and auxiliary materials:

[0163] White sugar: deionized water: activated carbon: ethanol = 15:15:0.45:15 (mass ratio W / W)

[0164] 2. Preparation process

[0165] (1) Take by weighing 1500g of white sugar, 1500g of deionized water, 45g of activated carbon, 1500g of ethanol, and set aside;

[0166] (2) Put the weighed white sugar into the tank, add the weighed deionized water, stir and heat to dissolve at 80-85°C;

[0167] (3) Add the activated carbon that has been weighed, decolorize for 20-30 minutes, and filter while it is hot;

[0168] (4) concentrating under reduced pressure at 50-95° C. until the sugar content in the concentrated white sugar solution is 80% to 85%;

[0169] (5) When the temperature is lowered to 50-70°C, slowly add the weighed ethanol;

[0170] (6) Continue to cool down to 20-25°C, stir and crystallize for 3-4 hours;

[0171] (7) Centrifugal crystallized re...

Embodiment 2

[0174] The preparation of embodiment 2 compound refined white sugar ointment

[0175] 1. The proportion of raw and auxiliary materials:

[0176] Refined sugar: neomycin sulfate: citric acid and sodium hydroxide buffer (pH 4.2): poloxamer: glycerol: polyethylene glycol 400: sodium alginate=70:3:18:1:1:3 : 0.3 (mass ratio W / W)

[0177] 2. Preparation process

[0178] (1) Weigh 180g of citric acid and sodium hydroxide buffer (pH 4.2), 700g of refined sugar, 30g of neomycin sulfate, 10g of poloxamer, 10g of glycerin, 30g of polyethylene glycol 400, and 3g of sodium alginate ,spare;

[0179] (2) Put the weighed refined white sugar into the tank, add citric acid and sodium hydroxide buffer solution (pH is 4.2), start stirring and heat up until it is completely dissolved, continue to heat up to 120-122°C to keep warm, and keep 15- 20 minutes; then cool down to 80-90°C, keep warm for later use;

[0180] (3) Put the weighed polyethylene glycol 400, glycerin, poloxamer and sodium a...

Embodiment 3

[0183] The preparation of embodiment 3 compound refined white sugar powder

[0184] 1. The proportion of raw and auxiliary materials:

[0185] Refined sugar: kanamycin sulfate: hydroxypropyl cellulose = 70:3:27 (mass ratio W / W)

[0186] 2. Preparation process

[0187] (1) Get 700g of refined white sugar and 270g of hydroxypropyl cellulose of prescription quantity, mix, pulverize, cross 325 mesh medicinal sieves;

[0188] (2) weigh kanamycin sulfate 30g according to the prescription ratio, and set aside;

[0189] (3) The kanamycin sulfate that weighs is put into (1) that has sieved, mixes in mixer;

[0190] (4) Packing, inspection, storage.

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Abstract

The invention discloses an external medicinal composition for treating skin ulcers (bedsores, burn ulcers and crural region ulcers) and a preparation method thereof, and belongs to the technical field of medicaments. The compound refined white sugar formulation of the composition of the invention is a medicinal composition which is prepared by mixing the medicinal active ingredients such as refined white sugar, neomycin sulfate (or kanamycin sulfate or povidone iodine) and a medicinal diluent or a carrier. In a skin external medicine administration form, the formulation of the composition canbe powder or ointment which is used for treating the skin ulcers such as the bedsores, the burn ulcers, the crural region ulcers and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, and relates to a composition of an externally used medicine for treating skin ulcers (decubitus ulcers, scald ulcers, calf ulcers) and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Skin ulcer is one of the more common clinical complications, and its formation factors are various. Refractory ulcers are often caused by long-term uncontrolled primary diseases such as burns, scalds, and diabetes. It brings great pain to patients and seriously affects their quality of life. [0003] Chronic skin ulcers, also known as refractory ulcers, are more common in the elderly, especially those with diabetes, vasculitis, and lower extremity venous reflux disorders. With the aging trend of the population and the increase in the incidence of diabetes and cardiovascular diseases, the incidence of chronic skin ulcers has al...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7036A61K31/7016A61K31/79A61K9/14A61K9/06A61P17/02
Inventor 刘慧乔俊超邵茂生王洪波赵得华
Owner JINAN SUNNYPHARMACY
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