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External medicinal composition for treating skin ulcer and preparation method thereof

A technology for external use of drugs and skin ulcers, which is applied in the field of medicine and can solve problems such as clinical application limitations

Active Publication Date: 2010-11-24
JINAN SUNNYPHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In a word, the above treatment methods all have different degrees of defects, which greatly restrict the clinical application.

Method used

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  • External medicinal composition for treating skin ulcer and preparation method thereof
  • External medicinal composition for treating skin ulcer and preparation method thereof
  • External medicinal composition for treating skin ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0162] Example 1 Preparation of refined white sugar

[0163] 1. The proportion of raw and auxiliary materials:

[0164] White sugar: deionized water: activated carbon: ethanol=15:15:0.45:15 (mass ratio W / W)

[0165] 2. Preparation process

[0166] (1) Weigh 1500g white sugar, 1500g deionized water, 45g activated carbon, and 1500g ethanol for use;

[0167] (2) Put the weighed sugar into the tank, add the weighed deionized water, stir and heat 80-85℃ to dissolve;

[0168] (3) Add the weighed activated carbon, decolorize for 20-30 minutes, and filter while it is hot;

[0169] (4) Concentrate under reduced pressure at 50-95°C until the sugar content in the white sugar concentrate is 80%-85%;

[0170] (5) When the temperature is lowered to 50-70°C, slowly add the weighed ethanol;

[0171] (6) Continue to cool down to 20-25°C, stir and crystallize for 3-4 hours;

[0172] (7) Centrifugal crystallized refined sugar;

[0173] (8) Dry it at 105-110℃ for 3-4 hours;

[0174] (9) Qualified inspection; pack...

Embodiment 2

[0175] Example 2 Preparation of compound refined white sugar ointment

[0176] 1. The proportion of raw and auxiliary materials:

[0177] Refined white sugar: neomycin sulfate: citric acid and sodium hydroxide buffer (pH 4.2): poloxamer: glycerol: polyethylene glycol 400: sodium alginate = 70:3:18:1:1:1:3 : 0.3 (mass ratio W / W)

[0178] 2. Preparation process

[0179] (1) Weigh 180g of citric acid and sodium hydroxide buffer (pH 4.2), 700g of refined sugar, 30g of neomycin sulfate, 10g of poloxamer, 10g of glycerin, 30g of polyethylene glycol 400, and 3g of sodium alginate ,spare;

[0180] (2) Put the weighed refined white sugar into the tank, add citric acid and sodium hydroxide buffer (pH 4.2), turn on the stirring and raise the temperature until it is completely dissolved, continue to heat up to 120-122°C for heat preservation, and keep it for 15- 20 minutes; then after cooling down to 80-90℃, keep warm for use;

[0181] (3) Put the weighed polyethylene glycol 400, glycerin, poloxa...

Embodiment 3

[0184] Example 3 Preparation of compound refined white sugar powder

[0185] 1. The proportion of raw and auxiliary materials:

[0186] Refined white sugar: kanamycin sulfate: hydroxypropyl cellulose=70:3:27 (mass ratio W / W)

[0187] 2. Preparation process

[0188] (1) Take 700 g of refined white sugar and 270 g of hydroxypropyl cellulose in a prescription amount, mix, crush, and pass through a 325 mesh medicinal sieve;

[0189] (2) Weigh 30g of kanamycin sulfate in proportion to the prescription and reserve;

[0190] (3) Put the weighed kanamycin sulfate into the sieved (1), and mix in the mixer;

[0191] (4) Packaging, inspection and storage.

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Abstract

The invention discloses an external medicinal composition for treating skin ulcers (bedsores, burn ulcers and crural region ulcers) and a preparation method thereof, and belongs to the technical field of medicaments. The compound refined white sugar formulation of the composition of the invention is a medicinal composition which is prepared by mixing the medicinal active ingredients such as refined white sugar, neomycin sulfate (or kanamycin sulfate or povidone iodine) and a medicinal diluent or a carrier. In a skin external medicine administration form, the formulation of the composition can be powder or ointment which is used for treating the skin ulcers such as the bedsores, the burn ulcers, the crural region ulcers and the like.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition and a preparation method thereof, and relates to a composition of an external medicine for treating skin ulcers (bedsores, scald ulcers, and calf ulcers) and a preparation method thereof, and belongs to the technical field of medicine. Background technique [0002] Skin ulcers are one of the more common clinical complications, with various factors. Refractory ulcers are often caused by long-term uncontrollable primary diseases such as burns, scalds, and diabetes. If the treatment method is improper, local inflammation may occur, and even systemic inflammatory reactions may occur. The course of the disease is repeated, prolonged and difficult to heal. The patient brings great pain and seriously affects his quality of life. [0003] Chronic skin ulcers, also known as refractory ulcers, are more common in the elderly, especially in the elderly with diabetes, vasculitis and venous reflux disorder of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K31/7016A61K31/79A61K9/14A61K9/06A61P17/02
Inventor 刘慧乔俊超邵茂生王洪波赵得华
Owner JINAN SUNNYPHARMACY
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