Method for obtaining race specific loci and race inference system and application thereof

Abstract

The invention provides a method for obtaining race specific loci and a race inference system and application thereof. The method comprises the following steps: selecting black, white and yellow race groups; obtaining SNP loci in genomes of the black, white and yellow race groups; selecting the SNP loci in pigmentation genes and xenobiotic metabolic enzyme genes of the black, white and yellow racegroups; screening the ancestor information marker loci of the black, white and yellow race groups from the selected SNP loci; and screening the specific loci of the black, white and yellow races fromthe ancestor information marker loci. The screened specific loci of the black, white and yellow races are integrated, thus obtaining the black, white and yellow race inference system which can be used for carrying out black, white and yellow race origin inference of the individual with unknown origin accurately and efficiently.

Description

technical field [0001] The invention relates to the field of bioinformatics, in particular to a method for obtaining race-specific loci using bioinformatics methods, a race inference system and applications thereof. Background technique [0002] The human genome has approximately 3.2 billion base pairs. 99.9% of the base pair sequences in different human genomes are the same, and only less than one-thousandth of the sequences are different. The main form of these differences is the DNA polymorphism called "Single nucleotide polymorphism (SNP)", which is caused by the variation of a single nucleotide on the DNA chain. This less than one-in-a-thousandth difference not only determines whether people are prone to certain diseases, but also determines their differences in height, skin color and body shape. Single nucleotide polymorphism (Singlenucleotide polymorphism, SNP) is the third generation of genetic markers after restriction fragment length polymorphism (restriction fra...

AI Technical Summary

Problems solved by technology

[0004] Under normal circumstances or occasions, it is possible to discriminate the origin of black, white, and yellow individuals from unknown sources based on human skin color, facial features, etc., through visually identifiable features. There are very large limitations when searching for the source of black, white, and yellow races based on the above-mentioned simple visual features such as severely damaged corpses that are difficult to identify, residual human blood and semen, etc. For some normal individual samples, such as a mixed-race suspect, if the ancestral background must be determined to exclude it, it is obviously impossible to accurately infer the origin of the race based on its skin color, facial features and other characteristics

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