Method for obtaining race specific loci and race inference system and application thereof

A specific and ethnic technology, applied in the field of bioinformatics, can solve the problem of inability to infer accurate ethnic origin, achieve the effect of accurate and effective individual origin inference, and expand the scope of inspection materials

Active Publication Date: 2011-01-26
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Under normal circumstances or occasions, it is possible to discriminate the origin of black, white, and yellow individuals from unknown sources based on human skin color, facial features, etc., through visually identifiable features. There are very large limitations when searching for the source of black, white, and yellow races based on the above-mentioned simple visual features such as severely damaged corpses that are difficult to identify, residual human blood and semen, etc. For some normal individual samples, such as a mixed-race suspect, if the ancestral background must be determined to exclude it, it is obviously impossible to accurately infer the origin of the race based on its skin color, facial features and other characteristics

Method used

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  • Method for obtaining race specific loci and race inference system and application thereof
  • Method for obtaining race specific loci and race inference system and application thereof
  • Method for obtaining race specific loci and race inference system and application thereof

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Embodiment 1

[0028] Through this embodiment, a method for obtaining a black, white, and yellow race estimation system provided by the present invention is specifically described.

[0029] 1. First, the black, white, and yellow race-specific loci are obtained through the following steps:

[0030] 1. Preferably from the HapMap database, a black group composed of 83 Africans living in the United States and 167 Africans living in Africa, a white group composed of 165 Europeans living in the United States, and a white group composed of 84 Africans living in Beijing Living Han people, 85 Han people living in the U.S. and 86 Japanese living in Tokyo formed a yellow group as the black, white and yellow race groups of this embodiment;

[0031] The above-mentioned black, white, and yellow ethnic groups are composed of people from six geographical regions. Because of the large geographical distance and obvious differences in characteristics, it is easy to obtain high-quality isolate samples. Using th...

Embodiment 2

[0071] A black, white, and yellow race inference system provided by the present invention is obtained by the method of the black, white, and yellow race inference system described in Example 1. The system consists of 16 RSL loci and the log likelihood ratio of each genotype composed of alleles of each RSL locus, among which the 16 RSL loci are: rs11264300, rs28777, rs12668421, rs4646437, rs7048117, rs686016, rs11018541, rs2583939, rs3782972, rs8012948, rs7170451, rs728404, rs2470102, rs885479, rs1205357 and rs7290134. The system achieves an average resolving power of 10 10 The 16 RSL loci are collected, and the log likelihood ratios of each genotype composed of the alleles of each RSL locus are collected. This system can be used to accurately and efficiently infer black, white, and yellow races.

[0072] Methods for inferring the origin of black, white, and yellow races of individuals of unknown origin using the above-mentioned system include:

[0073] 1. Obtain the SNP site...

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Abstract

The invention provides a method for obtaining race specific loci and a race inference system and application thereof. The method comprises the following steps: selecting black, white and yellow race groups; obtaining SNP loci in genomes of the black, white and yellow race groups; selecting the SNP loci in pigmentation genes and xenobiotic metabolic enzyme genes of the black, white and yellow racegroups; screening the ancestor information marker loci of the black, white and yellow race groups from the selected SNP loci; and screening the specific loci of the black, white and yellow races fromthe ancestor information marker loci. The screened specific loci of the black, white and yellow races are integrated, thus obtaining the black, white and yellow race inference system which can be used for carrying out black, white and yellow race origin inference of the individual with unknown origin accurately and efficiently.

Description

technical field [0001] The invention relates to the field of bioinformatics, in particular to a method for obtaining race-specific loci using bioinformatics methods, a race inference system and applications thereof. Background technique [0002] The human genome has approximately 3.2 billion base pairs. 99.9% of the base pair sequences in different human genomes are the same, and only less than one-thousandth of the sequences are different. The main form of these differences is the DNA polymorphism called "Single nucleotide polymorphism (SNP)", which is caused by the variation of a single nucleotide on the DNA chain. This less than one-in-a-thousandth difference not only determines whether people are prone to certain diseases, but also determines their differences in height, skin color and body shape. Single nucleotide polymorphism (Singlenucleotide polymorphism, SNP) is the third generation of genetic markers after restriction fragment length polymorphism (restriction fra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 李彩霞胡兰魏以梁
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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