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Anti-methicillin-resistant staphylococcus aureus agent and anti-vancomycin-resistant enterococcus agent

一种抗耐甲氧西林、葡萄球菌的技术，应用在抗细菌药、杀菌剂、杀生剂等方向

Inactive Publication Date: 2011-01-26
POKKA SAPPORO FOOD & BEVERAGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of Macaranga tanarius extract on MRSA and VRE has not yet been elucidated, and Patent Document 3 does not explain this at all

Method used

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  • Anti-methicillin-resistant staphylococcus aureus agent and anti-vancomycin-resistant enterococcus agent
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  • Anti-methicillin-resistant staphylococcus aureus agent and anti-vancomycin-resistant enterococcus agent

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Experimental program
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Effect test

no. 1 approach

[0018] Now, the anti-MRSA agent according to the first embodiment of the present invention will be described.

[0019] The anti-MRSA agent of the present embodiment contains, as an active ingredient, an Oobagi extract extracted from Oobagi with an extraction solvent including at least one organic solvent. Oobagi also known as Macaranga tanarius (Macaranga tanarius), is a dioecious broad-leaved evergreen tree belonging to the genus Macaranga tanarius in the Euphorbiaceae family. Macaranga tanarius grows, for example, in Southeast Asia, such as Okinawa (southern Japan), Taiwan, southern China, the Malay Peninsula, the Philippines, Malaysia, Indonesia, and Thailand, and northern Australia. Macaranga tanica grows significantly faster than other trees and can grow on degraded land.

[0020] All the organs of Macaranga tanarius and the components of each organ can be used as raw material for extraction with extraction solvents. The raw material for extraction may be one organ of M...

no. 2 approach

[0038] We will describe the anti-VRE agent of the second embodiment of the present invention focusing on differences from the anti-MRSA agent of the first embodiment described above.

[0039] Similar to the anti-MRSA agent, the anti-VRE agent of the second embodiment contains as an active ingredient an Oobagi extract extracted from Oobagi with an extraction solvent including at least one organic solvent.

[0040] The anti-VRE agent may contain components other than Macaranga tanarius extract as long as the anti-VRE activity is not impaired. Examples of ingredients that may be included in the anti-VRE agent include excipients, bases, emulsifiers, stabilizers, and flavoring agents in addition to the Macaranga tanarius extract.

[0041] The anti-VRE agent may be in liquid or solid form. The dosage form of the anti-VRE agent is not specifically limited, and may be, for example, powder, powder, granule, tablet, capsule, pill or liquid.

[0042] Anti-VRE agents can be used as, for...

Embodiment 1

[0051]

[0052] Thaw frozen raw Macaranga tannica leaves harvested in Okinawa, and cut these leaves into small pieces with scissors. Thirty grams of minced raw leaves were submerged in 100 mL of a solvent mixture consisting of 90 parts (by volume) of ethanol and 10 parts (by volume) of water, and kept at room temperature for 2 weeks, followed by filtration to obtain blood as The filtrate of the tung extract solution. The Macaranga tanarius extract solution was lyophilized to prepare a Macaranga tanarius extract, which is a powder of solid content contained in the Macaranga tanarius extract solution. when based on figure 1 When calculating the chromatogram shown in , the total concentration of Ningfei-A, Ningfei-B and Ningfei-C (ie the concentration of Nymphaeus) in the Macaranga tanarius extract in the powder form is 50% by mass, and the The chromatograms were obtained by analyzing the Macaranga tanarius extract under the following HPLC conditions.

[0053] HPLC condition...

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Abstract

Disclosed are an anti-methicillin-resistant Staphylococcus aureus agent (an anti-MRSA agent) and an anti-vancomycin-resistant Enterococcus agent (an anti-VRE agent), each of which comprises, as an active ingredient, an Macaranga tanarius extract that is extracted from a plant Macaranga tanarius with an extraction solvent comprising at least an organic solvent. Alternatively, each of the anti-MRSA agent and the anti-VRE agent may comprise at least one member selected from nymphaeol-A, nymphaeol-B and nymphaeol-C as an active ingredient.

Description

technical field [0001] The present invention relates to a drug against methicillin-resistant staphylococcus aureus and a drug against vancomycin-resistant enterococcus. Background technique [0002] Methicillin-resistant Staphylococcus aureus (MRSA) is a strain of β-lactam antibiotics such as cephem antibiotics including penicillin antibiotics (methicillin is classified as such), monobactam antibiotics and carbapenicillins Antibiotic-resistant multidrug-resistant bacteria. In addition to β-lactam antibiotics, MRSA is also known to show resistance to, for example, aminoglycoside antibiotics and macrolide antibiotics. [0003] Vancomycin, teicoplanin, arbekacin, and linezolid are used as anti-MRSA drugs. In particular, the emergence of vancomycin-resistant bacteria has been very rare, and thus vancomycin has been considered effective in the treatment of MRSA infections. Recently, however, the emergence of vancomycin-resistant enterococci (VRE) such as E. faecalis and E. fae...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A01N43/16A01N65/18A61K31/353A01P3/00A61P31/04C07D311/32
CPCA61K31/353A01N65/00A61K36/47C07D311/32A61P3/00A61P31/04A01N65/18
Inventor 后藤崇辉福本修一
Owner POKKA SAPPORO FOOD & BEVERAGE
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