Compound immunopotentiator for sea cucumber and preparation method thereof

The technology of an immune enhancer and a compound recipe is applied in the field of compound immune enhancer for sea cucumber and its preparation, which can solve the problems such as the utilization rate of the finished product, and achieve the effects of improving the use efficiency, taking effect quickly, and ensuring food safety.

Inactive Publication Date: 2011-02-09
MARICULTURE INST OF SHANDONG PROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to avoid the use of antibiotics in the prevention and treatment of sea cucumber diseases and overcome the problem of low utilization rate of existing Chinese herbal medicine products, the present invention provides a compound immune enhancer for sea cucumbers and a preparation method thereof, which are safe and efficient

Method used

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  • Compound immunopotentiator for sea cucumber and preparation method thereof
  • Compound immunopotentiator for sea cucumber and preparation method thereof
  • Compound immunopotentiator for sea cucumber and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1, weigh 30 g of sodium alginate and dissolve it in 1000 ml of distilled water, weigh 5 g of astragalus polysaccharide extract and pachyrhiza polysaccharide extract, and slowly add to the sodium alginate solution, during which a magnetic stirrer is used to continuously stir, and the action time is After 30 minutes, a gel solution of the two polysaccharide extracts and sodium alginate was formed at this time. Both the content of astragalus polysaccharide in the extract of astragalus polysaccharide and the content of polysaccharide in pachyrhiza polysaccharide are 50%. Weigh 30g CaCl 2 Dissolve in 1000ml of distilled water, the pH value is about 5, use the orifice instrument to squeeze the gel liquid into microgel beads and put them into the CaCl 2 In the solution, the action time is 30 minutes to form mixed particles. Take by weighing 10g chitosan, be dissolved in 1000ml concentration and be in the acetic acid solution of 1%, the pH of described acetic acid sol...

Embodiment 2

[0038]Example 2, the immunopotentiator of this example uses the polysaccharide microcapsules prepared in Example 1 in conjunction with the live Bacillus subtilis preparation, wherein the added amount of the live Bacillus subtilis preparation is 1×10 9 cfu / g basal feed, the added amount of the polysaccharide microcapsules is 4% of the basal feed.

Embodiment 3

[0039] Example three, weigh 10 g of astragalus polysaccharide extract, 30 g of sodium alginate, and 30 g of CaCl 2 and 10g chitosan, wherein, the Astragalus polysaccharide content in the described Astragalus polysaccharide extract is 50%, the prepared sodium alginate solution concentration, CaCl 2 The concentration of the solution and the concentration of acetic acid used are consistent with those in Example 1, and the preparation steps are also the same. It is only necessary to replace the extract of astragalus polysaccharide and the extract of Poria cocos polysaccharide with only the extract of astragalus polysaccharide, which will not be repeated here. Finally, Astragalus polysaccharide microcapsules were prepared, and fed according to the weight of the polysaccharide microcapsules accounting for 4% of the basal feed.

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Abstract

The invention discloses a compound immunopotentiator for sea cucumber and a preparation method thereof, aims to solve the technical problems that antibiotic is used for preventing and controlling diseases of sea cucumber and the utilization rate of the conventional Chinese herbal medicine fished product is low, and provides a compound immunopotentiator for sea cucumber. In order to solve the problems, the technical scheme is that: the compound immunopotentiator for sea cucumber comprises polysaccharide microcapsules at least consisting of a core material and a wall material, wherein the wall material comprises sodium alginate and chitosan; the weight ratio of the core material to the sodium alginate to the chitosan is 1:(2.8-3.5):(1-2); and the core material is at least one of an astragalus polysaccharide extract and a pachymaran extract. Experiments prove that the immunopotentiator effectively improves the immunoprotection capacity of the sea cucumber, and is safe and high-efficiency.

Description

technical field [0001] The invention relates to the technical field of immune enhancers, in particular to a compound immune enhancer for sea cucumbers and a preparation method thereof. Background technique [0002] Sea cucumber has extremely high nutritional value and health care function, and its breeding industry has become a new industry in recent years. However, due to the increasingly prominent disease problems of sea cucumbers, they are easily infected by pathogens such as parasites, bacteria, viruses, and protozoa, causing huge economic losses. In order to control the occurrence of diseases and reduce losses, most producers use a large number of antibiotics to avoid diseases. Overuse of antibiotics will inevitably increase pathogen resistance and produce more virulent pathogens. At the same time, the possible drug residues will also affect the development of the industry and endanger human health. [0003] The immune effect of Chinese herbal medicine is significant, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K31/715A23K1/18A61P37/04A61K9/50A61K35/74A23K1/16A61K36/481A23K10/18A23K20/163A23K50/80A61K35/742
Inventor 李天保樊英王淑娴杨秀生于晓清朱安成王勇强
Owner MARICULTURE INST OF SHANDONG PROVINCE
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