Diminazene compound for veterinary use and preparation method of diminazene compound

A compound triazemidine and injection technology, which is applied in the field of veterinary compound triazemidine injection and its preparation, can solve the problems of high blood concentration, short duration, poor preventive effect, etc. Promotes cell growth and division, and enhances function

Inactive Publication Date: 2015-12-23
CHONGQING BULL ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The blood concentration is high after medication, but the duration is short, so it is mainly used for treatment, and the preventive effect is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The components and mass percentages of the compound triazine injection for animals of the present embodiment are:

[0024] Triazamidine 5%

[0025] Antipyrine 3%

[0026] Vitamin B 1 4%

[0027] Sodium bisulfite 0.01%

[0028] Dimethylacetamide 5%

[0029] The balance is water for injection.

[0030] The preparation method of the veterinary compound triazamidine injection of the present embodiment is as follows: firstly take 40% water for injection and place it in a preparation container, dissolve sodium bisulfite with an appropriate amount of water for injection, add it, and stir evenly, and saturate it with nitrogen for 10 minutes; Add full dose of B vitamins while stirring 1 , antipyrine, triazine, after the dissolution is complete, add the full amount of dimethylacetamide, add water for injection to 90% of the full amount, adjust the pH value to 7.0~7.5 with ethanolamine or glacial acetic acid, add water for injection to the full amount , saturated with nitro...

Embodiment 2

[0032] The components and mass percentages of the compound triazine injection for animals of the present embodiment are:

[0033] Triazamidine 5%

[0034] Analgin 3%

[0035] Vitamin B 2 4%

[0036] Sodium thiosulfate 0.1%

[0037] Propylene Glycol 7%

[0038] The balance is water for injection.

[0039] The preparation method of the veterinary compound triazamidine injection of this embodiment is: first take 40% water for injection and place it in a preparation container, dissolve sodium thiosulfate with an appropriate amount of water for injection, add it, and stir evenly, and saturate it with nitrogen for 10 minutes; Add full dose of B vitamins while stirring 2 , Analgin, Triazamidine, after stirring and dissolving, add the full amount of propylene glycol, and stir until completely dissolved; add water for injection to 90% of the total amount, adjust the pH value to 7.0~7.5 with ethanolamine or glacial acetic acid, and add water for injection to the full amount , sat...

Embodiment 3

[0041] The components and mass percentages of the compound triazine injection for animals of the present embodiment are:

[0042] Triazamidine 6%

[0043] Analgin 3%

[0044] Vitamin B 3 4%

[0045] Glyceryl Triacetate 10%

[0046] Disodium edetate 0.01%

[0047] The balance is water for injection.

[0048] The preparation method of the veterinary compound triazamidine injection of this embodiment is as follows: firstly take 40% water for injection and put it in a preparation container, dissolve disodium edetate with an appropriate amount of water for injection, add it, and stir evenly, and saturate it with nitrogen 10min; add the full amount of vitamin B while stirring 3 , Analgin, Triazamidine, after stirring and dissolving, add the full amount of glycerol triacetate and stir until completely dissolved; add water for injection to 90% of the total amount, adjust the pH value to 7.0~7.5 with ethanolamine or glacial acetic acid, add injection Water to full volume, satura...

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PUM

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Abstract

The invention discloses a diminazene compound for veterinary use and a preparation method of the diminazene compound. The diminazene compound mainly comprises, by mass, 5-6% of diminazene, 2-6% of pyrazolone medicine, 4-6% of Vitamin B and the balance menstruum for injection. The diminazene compound has the advantages that the diminazene compound is quick to absorb by adoption of intramuscular injection delivery and high in bioavailability; the pyrazolone medicine and the Vitamin B are combined to achieve a synergistic effect, so that adverse reaction can be reduced; the Vitamin B supplements nutrient substances of organisms, enhances organism immunity and improves parasite resistance of the organisms; since resistance of the organisms is enhanced, a disease course can be shortened, dosage is reduced and appearance of parasites resistant to the diminazene compound is delayed.

Description

technical field [0001] The invention relates to the technical field of veterinary drug injections, in particular to a veterinary compound triazine injection and a preparation method thereof. Background technique [0002] Triclomidine belongs to the class of aromatic diamidines and is a broad-spectrum anti-blood protozoal drug traditionally used. For example, it has effects on domestic animals Piroplasma, Trypanosoma, Amaranth and Eperythrozoon. It is used for livestock babesiosis and theileriasis caused by Piroplasma; trypanosomiasis and equine disease caused by trypanosoma; and blood protozoon diseases such as livestock eperythrozoonosis caused by Eperythrozoon. After administration, the blood concentration is high, but the duration is short, so it is mainly used for treatment, and the preventive effect is poor. The mechanism of action of this product is to selectively block the DNA synthesis and replication of the insect's kinetosome, and to produce an irreversible combi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/655A61K31/4152A61P33/00A61P29/00A61P3/02A61K31/4415A61K31/455A61K31/51A61K31/525A61K31/714
Inventor 吴俊伟陈红伟曾杨梅姜波邓开锋王戬喻琴
Owner CHONGQING BULL ANIMAL PHARMA
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