Compound norfloxacin nicotinic soluble powder and preparation method thereof

Abstract

The invention discloses compound norfloxacin nicotinic soluble powder and a preparation method thereof, and provides soluble powder capable of treating poultry gastrointestinal infection and lowering drug resistance probability and the preparation method thereof. The compound norfloxacin nicotinic soluble powder is prepared from the following raw materials in percentage by weight: 3-10% of norfloxacin nicotinate, 5-15% of neomycin sulfate, 5% of sodium chloride, 5% of potassium chloride and the balance anhydrous glucose. In the invention, the norfloxacin nicotinate and the neomycin sulfate are taken as antibacterial ingredients, thus achieving double efficacies and effectively reducing the probability of bacterial drug resistance, wherein, the norfloxacin nicotinate can be absorbed into the bloodstream for killing pathogenic bacteria through circulation secretion, and the neomycin sulfate is rarely absorbed by oral administration and directly applied to intestinal tract for producing contact sterilization effect, so the norfloxacin nicotinate and the neomycin sulfate have good effect of killing the pathogenic bacteria resulting in the poultry gastrointestinal infection from the two aspects; and the combination of the sodium chloride and the potassium chloride can make up electrolyte loss caused by excessive diarrhea of infected poultry. Therefore, the combination of the drugs can strengthen the curative effect on the poultry bacterial gastrointestinal infection.

Description

technical field [0001] The invention relates to a compound norfloxacin niacin soluble powder for treating poultry bacterial intestinal infection and a preparation method thereof. Background technique [0002] Avian bacterial intestinal infection is a common disease in poultry. The pathogen is mainly caused by a single or mixed infection of Gram-negative bacteria such as Escherichia coli, Salmonella, and Pseudomonas aeruginosa. Sometimes it is complicated by mycoplasma infection. The diseased poultry grows poorly and develops rapidly, manifested as diarrhea, diarrhea, and white, gray, yellow or yellow-green loose stools, some of which are watery, with some feed residues or tissue fragments, etc. The diseased poultry is severely dehydrated and has an inflammatory reaction Severe and may cause excessive loss of electrolytes, debilitating symptoms, and high mortality. [0003] At present, the disease tends to be mixed and complicated. The pathogenic bacteria are resident bacter...

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Problems solved by technology

[0003] At present, the disease tends to be mixed and complicated. The pathogenic bacteria are resident bacteria in the body and have serious drug resistance. Now the single dru