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Application of pedunculoside in preparing medicine for treating cerebral ischemia

A kind of technology with pelicin and cerebral ischemia, which is applied in the field of drugs for cerebrovascular system diseases, can solve the problems that the process conditions cannot meet the needs of industrial production, long cycle, and small output, so as to reduce the area of ​​cerebral infarction and inhibit brain tissue. Increased water content, significant anti-ischemic effect

Inactive Publication Date: 2011-03-02
李超生 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The deficiencies of the prior art are that highly toxic chloroform needs to be degreased and separated by silica gel column chromatography, the output is small, the cycle is long, the cost is high, the operation is complicated, and the process conditions cannot meet the needs of industrial production

Method used

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  • Application of pedunculoside in preparing medicine for treating cerebral ischemia
  • Application of pedunculoside in preparing medicine for treating cerebral ischemia
  • Application of pedunculoside in preparing medicine for treating cerebral ischemia

Examples

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Embodiment 1

[0021] Example 1: Rescue 2000g of Bing coarse powder, reflux extraction with 6 times 80% ethanol three times, extract for 2, 1, 1 hour respectively, filter, combine the filtrates, concentrate to extract, add 6000ml of water, heat in a water bath, stir , standing overnight, filtered to obtain precipitate and filtrate. The precipitate is extracted with 50-95% ethanol under reflux, filtered, the filtrate is concentrated, placed, filtered, and the precipitate is dried to obtain the total saponins, and the total saponins are crystallized by adding 10-100 times of 50-95% ethanol to obtain a part of Ilex ilex Glycosides. Concentrate the filtrate to 1000ml, let it cool to room temperature, filter, wash the precipitate with appropriate amount of water three times, dry, crystallize with 10-50 times the amount of 50-95% ethanol, and obtain another part of the coarse crystal of glucoside, twice The prepared pelicosides are combined, and recrystallized multiple times with 10-100 times the...

Embodiment 2

[0023] Take the pelicoside prepared by the method of Example 1, and adopt the well-known preparation method of the infusion solution in the technical field to prepare the pelicoside sodium chloride injection and the pelicoside glucose injection: the pelicoside 40 mg, Sodium Chloride 2.25g, made into Pelicoside Sodium Chloride Injection, its specification is 500ml, intravenous injection, 1 bottle each time, once a day; Glucoside injection, its specification is 500ml, intravenous injection, 1 bottle each time, once a day.

Embodiment 3

[0025] Take 20 g of pelicin prepared according to the method of Example 1, add an appropriate amount of water for injection, adjust the pH value to 7 with sodium carbonate, stir and dissolve, and then add manna for injection equivalent to 10-15% of pelicin Alcohol, sterilized and filtered, determined the content, divided into 1000 tubes, 20mg per tube, sealed, and obtained. Intravenous injection, 40mg each time, once a day.

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Abstract

The invention discloses an application of pedunculoside in preparing a medicine for treating cerebral ischemia disease. An effective treatment dose of pedunculoside and a pharmaceutically acceptable carrier are prepared into the medicine for treating the cerebral ischemia disease, and the medicine can be pills, oral solution, injection, infusion agents, freeze-dried powder, microcapsules, capsules, or tablets. The medicines can be used for preventing and treating diseases such as apoplexy, cerebral infarction and the like.

Description

[0001] This application is a divisional application of the invention patent application entitled "Preparation Method and Application of Pelate Glycoside" with application number 200610017186.7 submitted to the State Intellectual Property Office of China on September 19, 2006. technical field [0002] The present invention relates to the field of drugs for cerebrovascular system diseases, in particular to the application of glucoside in the preparation of drugs for treating cerebral ischemia. Background technique [0003] Jiubing is the bark of Ilex rotunda Thunb., a plant in the Ilex family Ilex family. It is mainly produced in Guangxi and Guangdong provinces. It has the effects of clearing away heat and detoxification, reducing swelling and relieving pain. For colds, tonsillitis, sore throat, acute gastroenteritis, rheumatic bone pain; external use for bruises, carbuncle furuncle sores, traumatic bleeding, burns and scalds. The chemical components mainly contain triterpenoi...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P9/10
Inventor 李超生
Owner 李超生
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