Synergistic microbicidal compositions
A technology for killing microbes and compositions, applied in biocides, chemicals for biological control, animal repellants, etc., can solve the problems of inability to provide microbial control, poor microbial activity, etc.
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[0045] Materials and methods
[0046] The synergistic effect of the combinations of the invention on the microorganisms was demonstrated by testing a wide range of compound concentrations and ratios. Those skilled in the art will recognize that the susceptibility of other microorganisms to a particular combination will vary and thus the concentrations, ratios, of one or both compounds may vary from those specifically set forth in these examples. The concentrations and ratios may also vary under different test conditions or different test methods.
[0047] One measure of synergy is the industry-accepted method proposed by Kull, F.C.; Eisman, P.C.; Sylwestrowicz, H.D. and Mayer, R.L. in Applied Microbiology 9:538-541 (1961), which Use the ratio determined by:
[0048] Q a / Q A +Q b / Q B = Synergy Index ("SI")
[0049] in:
[0050] Q A = Concentration of Compound A (first component) that produces the endpoint when used alone (MIC of Compound A), in ppm.
[0051] Q a ...
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